The Biosynthesis of Polyketide Metabolites by Dinoflagellates

Rein, Kathleen S.; Snyder, Richard V.

doi:10.1016/s0065-2164(06)59004-5

Cited by 43 publications

(39 citation statements)

References 126 publications

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“…These studies corroborated the polyketide origin of ladder polyethers, which is also supported by genetic studies [125][126][127][128], but did not illuminate any subsequent epoxidation or cyclization steps. Some remote evidence in support of this hypothesis can be taken from biosynthetic studies on a related natural product, okadaic acid [129,130], and isolation of 27,28-epoxybrevetoxin B from Karenia brevis [131].…”

Section: Ladder Polyetherssupporting

confidence: 57%

Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening

Vilotijević

Jamison

2011

Biomimetic Organic Synthesis

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Section: Ladder Polyetherssupporting

confidence: 57%

Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening

Vilotijević

Jamison

2011

Biomimetic Organic Synthesis

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“…SAHH was related to the early G 1 phase of the cell cycle of A. fundyense (47), whereas paralytic shellfish toxin production was correlated with SAM-S and SAHH expression (strain CAWD44, group IV) (19). In dinoflagellates, many toxins and bioactive compounds are polyketides, whose biosynthesis is mediated by polyketide synthase (PKS) enzymes (40). A dinoflagellate PKS-like protein and homologs of type I PKS were detected in our library.…”

Section: Vol 76 2010 Transcriptome Of Proliferating Alexandrium Celmentioning

confidence: 90%

Gene Expression in Proliferating Cells of the Dinoflagellate Alexandrium catenella (Dinophyceae)

Toulza

Shin

Blanc

et al. 2010

Appl Environ Microbiol

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Understanding the conditions leading to harmful algal blooms, especially those produced by toxic dinoflagellate species, is important for environmental and health safety. In addition to investigations into the environmental conditions necessary for the formation of toxic blooms, we postulate that investigating gene expression in proliferating cells is essential for understanding bloom dynamics. Expressed sequence tags were produced from cultured cells of the toxic dinoflagellate Alexandrium catenella sampled during the initiation phase of growth using Sanger's method and by 454 pyrosequencing. A significant proportion of identified genes (ca. 25%) represented enzymes and proteins that participate in a variety of cellular regulatory mechanisms that may characterize proliferating cells, e.g., control of the cell cycle and division, regulation of transcription, translation and posttranslational protein modifications, signaling, intracellular trafficking, and transport. All of the several genes selected for gene expression assays due to their involvement in metabolism and the cell cycle were overexpressed during exponential growth. These data will be useful for investigating the mechanisms underlying growth and toxin production in toxic Alexandrium species and for studying and monitoring the development of toxic blooms.

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“…In a few examples, stable isotope labelling experiments have shown that toxins and related compounds from dinoflagellates are of polyketide origin (Rein & Snyder, 2006;Kellmann et al, 2010). In a few examples, stable isotope labelling experiments have shown that toxins and related compounds from dinoflagellates are of polyketide origin (Rein & Snyder, 2006;Kellmann et al, 2010).…”

Section: Polyketides From Dinoflagellatesmentioning

confidence: 99%

“…In a few examples, stable isotope labelling experiments have shown that toxins and related compounds from dinoflagellates are of polyketide origin (Rein & Snyder, 2006;Kellmann et al, 2010). For example, such deletions are observed in amphidinolides (Rein & Snyder, 2006), and they are a hallmark of dinoflagellate polyketides. Macrolides (macro-lactones) are another group of well-known dinoflagellate polyketides, exemplified by the amphidinolide toxins from Amphidinium species (Kobayashi & Kubota, 2007).…”

Section: Polyketides From Dinoflagellatesmentioning

confidence: 99%

Microalgae in the postgenomic era: a blooming reservoir for new natural products

Sasso¹,

Pohnert²,

Lohr³

et al. 2012

FEMS Microbiol Rev

141

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Bacteria, fungi, algae and higher plants are the most prolific producers of natural products (secondary metabolites). Compared to macroalgae, considerably fewer natural products have been isolated from microalgae, which offer the possibility of obtaining sufficient and well-defined biological material from laboratory cultures. Interest in microalgae is reinforced by large-scale data sets from genome sequencing projects and the development of genetic tools such as transformation protocols. This review highlights what is currently known about the biosynthesis and biological role of natural products in microalgae, with examples from isoprenoids, complex polyketides, nonribosomal peptides, polyunsaturated fatty acids and oxylipins, alkaloids, and aromatic secondary metabolites. In addition, we introduce a bioinformatic analysis of available genome sequences from totally 16 microalgae, belonging to the green and red algae, heterokonts and haptophytes. The results suggest that the biosynthetic potential of microalgae is underestimated and many microalgal natural products remain to be discovered.

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The Biosynthesis of Polyketide Metabolites by Dinoflagellates

Cited by 43 publications

References 126 publications

Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening

Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening

Gene Expression in Proliferating Cells of the Dinoflagellate Alexandrium catenella (Dinophyceae)

Microalgae in the postgenomic era: a blooming reservoir for new natural products

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