Biosynthetic studies of human ovarian arrhenoblastomatous tissue in vitro II. Formation of androgens from dehydroisoandrosterone sulfate

Sandberg, Eugene C.; Jenkins, R. Clifton; Trifon, Harry M.

doi:10.1016/0039-128x(66)90098-5

Cited by 6 publications

(1 citation statement)

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“…Only 10-4% of the incubated DHA sulphate remained unmetabolized, 34-6% being iso¬ lated in the carrier DHA, 41-4 % in the androstenedione and 0-5 % in the testosterone. This high conversion of DHA sulphate is in contrast to the 0-1 % conversion to androstenedione by tissue from an arrhenoblastoma reported by Sandberg, Jenkins & Trifon (1966). They found only 'a small and indeterminate yield of testosterone'.…”

Section: Discussioncontrasting

confidence: 71%

A COMPARISON OF THE METABOLISM IN VITRO OF [7α-3h] DEHYDROEPIANDROSTERONE SULPHATE AND [4-14c] PREGNENOLONE BY TISSUE FROM a HILUS CELL TUMOUR OF THE OVARY

Fahmy¹,

Griffiths²,

Turnbull³

et al. 1968

Journal of Endocrinology

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Tissue from a hilus cell tumour of an ovary removed from a 58-yr.-old virilized woman was incubated simultaneously with [7\g=a\-3H]dehydroepiandrosterone sulphate (DHA sulphate) and [4-14C]pregnenolone. The tissue was chopped and incubated in Krebs-Ringer bicarbonate glucose medium without the addition of cofactors. Both steroids were efficiently metabolized by the tissue; 78\m=.\5and 1\m=.\2 % of the pregnenolone was converted to androstenedione and testosterone respectively, whereas 34\m=.\6 % of the incubated DHA sulphate was isolated in the carrier DHA, 41\m=.\4% in the androstenedione and 0\m=.\5% in the testosterone.

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Section: Discussioncontrasting

confidence: 71%