Biosynthetic Pathways to Glycosidase Inhibitors

Gomollón‐Bel, Fernando; Delso, J. Ignacio; Tejero, Tomás; Merino, Pedro

doi:10.2174/221279680801141112094818

Cited by 5 publications

(4 citation statements)

References 66 publications

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“…Thee arly to mid-1970s was clearly ah ive of incredible activity and ingenuity the accumulation of which eventually both led to the invention of the LIB,w hich has revolutionized our lives,a nd is connected to SSBs which in 2019 were highlighted as one of the top ten emerging innovations in chemistry by the International Union of Pure and Applied Chemistry (IU-PAC). [16] The Birth of The "Rocking-Chair Battery" Concept in the Late 1970s…”

Section: Angewandte Chemiementioning

confidence: 99%

From Solid‐Solution Electrodes and the Rocking‐Chair Concept to Today's Batteries

et al. 2019

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Lithium‐ion batteries (LIBs) have become ubiquitous power sources for small electronic devices, electric vehicles, and stationary energy storage systems. Despite the success of LIBs which is acknowledged by their increasing commodity market, the historical evolution of the chemistry behind the LIB technologies is laden with obstacles and yet to be unambiguously documented. This Viewpoint outlines chronologically the most essential findings related to today's LIBs, including commercial electrode and electrolyte materials, but furthermore also depicts how the today popular and widely emerging solid‐state batteries were instrumental at very early stages in the development of LIBs.

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Section: Angewandte Chemiementioning

confidence: 99%

From Solid‐Solution Electrodes and the Rocking‐Chair Concept to Today's Batteries

et al. 2019

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“…1-Deoxynojirimycin (1) is a piperidine alkaloid found in various plants such as Commelina communis, and in the Streptomyces and Bacillus bacteria. 52,53 It has antihyperglycemic, anti-obesity, and antiviral activities. 54 It has been reported to be effective against hepatitis, 55 influenza 56 and HIV.…”

Section: -Deoxynojirimycinmentioning

confidence: 99%

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Elufioye

Habtemariam

2020

TJNPR

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Coronaviruses (CoVs) are enveloped viruses that cause multiple respiratory and intestinal infections in humans and animals. 1 The term 'coronavirus' refers to the crown-like appearance of CoVs under electron microscope due to spike projections from the membrane. 2 These viruses were first described in the 1960s from patients with respiratory infections like the common cold. 3 Since then, several human coronaviruses (HCoVs) have been identified including the HCoV-Hong Kong University 1 (HKU1), HCoV-NL63; severe acute respiratory syndrome (SARS)-CoV; and Middle East respiratory syndrome (MERS)-CoV. 3 CoVs belong to the subfamilies Coronavirinae and Torovirinae of the family Coronaviridae in the order Nidovirales. 4 Based on phylogeny, they are divided into four genera as α-CoV, β-CoV, γ-CoV and δ-CoV. 5 The beta-CoV genus is further subdivided into four lineages (A, B, C, and D) 1 (Figure 1). Mammalian coronavirus include HCoV-229E and HCoV-NL63 which belong to the α-coronavirus class as well as HCoV-HKU1, SARS-CoV, MERS-CoV and HCoV-OC43 which are β-coronaviruses; while avian coronavirus is the γ-coronavirus and δ-coronavirus. 3 The novel coronavirus, 2019-nCoV, that caused the current global COVID-19 pandemic was first identified in December 2019 in the Wuhan region (Hubei Province) of China. Since then, the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses has formally designated the virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 6

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“…Biosynthetic studies, conducted by feeding 14 C-lysine to R. leguminicola cultures and recovering 14 C-slaframine, have demonstrated that slaframine is derived from lysine (Figure 2 D) ( 18 , 37 ), which is converted into pipecolic acid (Figure 2 E) ( 37 ). The incorporation of 14 C into slaframine decreased if non-radioactive pipecolic acid was fed along with 14 C-lysine, an indication that pipecolic acid was a more immediate precursor of slaframine than lysine ( 37 , 38 ). Pipecolic acid is a precursor of various microbial secondary metabolites ( 39 ).…”

Section: Alkaloid Production and Physiological Effectsmentioning

confidence: 99%

Blackpatch of Clover, Cause of Slobbers Syndrome: A Review of the Disease and the Pathogen, Rhizoctonia leguminicola

Kagan

2016

Front. Vet. Sci.

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Rhizoctonia leguminicola Gough and Elliott is a widely used name for the causal agent of blackpatch disease of red clover (Trifolium pratense L.). This fungal pathogen produces alkaloids (slaframine and swainsonine) that affect grazing mammals. Slaframine causes livestock to salivate profusely, and swainsonine causes neurological problems. Although the blackpatch fungus was classified as a Rhizoctonia species (phylum Basidiomycota), morphological studies have indicated that it is in the phylum Ascomycota, and sequencing data have indicated that it may be a new genus of ascomycete. The effects of the alkaloids on grazing mammals and their biosynthetic pathways have been extensively studied. In contrast, few studies have been done on management of the disease, which requires a greater understanding of the pathogen. Methods of disease management have included seed treatments and fungicides, but these have not been investigated since the 1950s. Searches for resistant cultivars have been limited. This review summarizes the biological effects and biosynthetic precursors of slaframine and swainsonine. Emphasis is placed on current knowledge about the epidemiology of blackpatch disease and the ecology and taxonomy of the pathogen. Possibilities for future research and disease management efforts are suggested.

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Biosynthetic Pathways to Glycosidase Inhibitors

Cited by 5 publications

References 66 publications

From Solid‐Solution Electrodes and the Rocking‐Chair Concept to Today's Batteries

From Solid‐Solution Electrodes and the Rocking‐Chair Concept to Today's Batteries

Drug Development for the Management of Corona Viruses: Insights from Natural Antiviral Agents

Blackpatch of Clover, Cause of Slobbers Syndrome: A Review of the Disease and the Pathogen, Rhizoctonia leguminicola

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