Biosynthesized Gold Nanoparticles Integrated Ointment Base for Repellent Activity Against Aedes aegypti L

Balasubramani, Sundararajan; Sathishkumar, Gnanasekar; Seetharaman, Prabu Kumar; Moola, Anil Kumar; Duraisamy, Saravanamoorthy Mutharasanallur; Mutayran, Al Anoud Saud Bin; Seshadri, Vidya Devanathadesikan; Thomas, Adelina; Kumari, B. D. Ranjitha; Sivaramakrishnan, S.; Kweka, Eliningaya J.; Zhou, Zhiqin

doi:10.1007/s13744-021-00920-z

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…A volume of the candidate repellent contained in a diluent solvent is then applied to one volunteer’s forearm (and the standard solution on another forearm). The time elapsed between the application of the repellents and the first mosquito bite in the treated arm was recorded and considered as protection time [ 192 , 193 , 194 ]. The percentage of mosquito bites is calculated for each trial using the following formula:

where NBUA = number of bites received by the untreated arm, and NBTA = number of bites received by the treated arm [ 192 ].…”

Section: Green Synthesized Plant-based Metallic Nanoparticles As a Mo...mentioning

confidence: 99%

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Mosquito-Borne Diseases and Their Control Strategies: An Overview Focused on Green Synthesized Plant-Based Metallic Nanoparticles

Onen

Luzala

Kigozi

et al. 2023

Insects

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Mosquitoes act as vectors of pathogens that cause most life-threatening diseases, such as malaria, Dengue, Chikungunya, Yellow fever, Zika, West Nile, Lymphatic filariasis, etc. To reduce the transmission of these mosquito-borne diseases in humans, several chemical, biological, mechanical, and pharmaceutical methods of control are used. However, these different strategies are facing important and timely challenges that include the rapid spread of highly invasive mosquitoes worldwide, the development of resistance in several mosquito species, and the recent outbreaks of novel arthropod-borne viruses (e.g., Dengue, Rift Valley fever, tick-borne encephalitis, West Nile, yellow fever, etc.). Therefore, the development of novel and effective methods of control is urgently needed to manage mosquito vectors. Adapting the principles of nanobiotechnology to mosquito vector control is one of the current approaches. As a single-step, eco-friendly, and biodegradable method that does not require the use of toxic chemicals, the green synthesis of nanoparticles using active toxic agents from plant extracts available since ancient times exhibits antagonistic responses and broad-spectrum target-specific activities against different species of vector mosquitoes. In this article, the current state of knowledge on the different mosquito control strategies in general, and on repellent and mosquitocidal plant-mediated synthesis of nanoparticles in particular, has been reviewed. By doing so, this review may open new doors for research on mosquito-borne diseases.

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where NBUA = number of bites received by the untreated arm, and NBTA = number of bites received by the treated arm [ 192 ].…”

Section: Green Synthesized Plant-based Metallic Nanoparticles As a Mo...mentioning

confidence: 99%

“…The second one concerns Artemisia vulgaris -synthesized gold nanoparticles that exhibited a protection time of 60% against Ae. aegypti [ 192 ].…”

Section: Green Synthesized Plant-based Metallic Nanoparticles As a Mo...mentioning

confidence: 99%

Mosquito-Borne Diseases and Their Control Strategies: An Overview Focused on Green Synthesized Plant-Based Metallic Nanoparticles

Onen

Luzala

Kigozi

et al. 2023

Insects

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“…Balasubramani and collaborators studied the larvicidal and repellent activity of Artemisia vulgaris leaf essential oil against the dengue vector Aedes aegypti (Balasubramani et al, 2018) and biosynthesized gold nanoparticles integrated ointment base for repellent activity against Aedes aegypti L. (Sundararajan et al, 2022). Balasubramani et al developed nanoemulsions from essential oil of Vitex negundo L. and demonstrated their antioxidant, antimicrobial and larvicidal efficacy (Aedes aegypti L.) (Balasubramani et al, 2017;Balasubramani et al, 2021).…”

Section: Compound Cyp2c9mentioning

confidence: 99%

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Bruna

Fernández²,

Urrejola³

et al. 2022

Front. Nat. Prod.

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The Mapuche and their ancestors have used D. winteri in traditional medicine. In the present study, the essential oil extract of D. winteri leaves (DW_EO) were characterized chemically and biologically to evaluate its pharmacological activity. In vitro antioxidant activity was assayed, and antitumor activity was evaluated in non-tumor and tumor-cell culture lines. Caenorhabditis elegans was used as a model to evaluate toxicity, and the chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry. The chemical oil composition was characterized principally of five major terpenes: 4 sesquiterpenes γ-Eudesmol (39.7%), β-Caryophyllene (33.7%), Elemol (25.9%), α-Eudesmol (0.3%) and 1 diterpene Kaunene (0.4%). By quantum calculations, it was determined that all oils have the ability to capture and yield electrons, which is consistent with the moderate antioxidant activity of DW_EO detected in vitro. Furthermore, by molecular docking is estimated that these oils can bind to proteins involved in the production of oxygen radicals. Of these proteins, CYP2C9 could bind energetically, reaching binding energy between −6.8 and −9.2 kCal/mol for the 5 terpenes studied, highlighting among these β-Caryophyllen and γ-Eudesmol. DW_EO has effect against H. pylori (MIC 32 μg/ml), S. aureus (MIC 8 μg/ml), E. coli (MIC 32 μg/ml) and C. albicans (MIC 64 μg/ml), β-Caryophyllen and γ -Eudesmol (MIC 64 μg/ml) and could selectively inhibit the proliferation of epithelial tumor cell lines but showed low against C. elegans (0.39–1.56 μg mL−1). Therefore, DW_EO may be used as a source of bioactive compounds in novel pharmacological treatments for medical application, agronomics, sanitation, and food.

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“…vulgaris , were evaluated the larvicidal activity of essential oils from stem and leaves (Govindaraj & Ranjithakumari, 2013; Lavor et al, 2012), the larvicidal and repellent action of essential oil from leaves (Balasubramani et al, 2018), and the alcoholic extract of leaves against A. aegypti (Ninditya et al, 2020). In addition, Sundararajan et al (2022) developed a nano‐ointment base integrated with biogenic gold nanoparticles from the essential oil of A. vulgaris L. with repellent activity against A. aegypti adults. Also reported to larvicidal, oviposition and ovicidal effects of a crude hexane extract of A. annua against A. aegypti , Anopheles sinensis and C. quinquefasciatus (Cheah et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Sundararajan et al (2022) developed a nano-ointment base integrated with biogenic gold nanoparticles from the essential oil of A. vulgaris L. with repellent activity against A. aegypti adults. Also reported to larvicidal, oviposition and ovicidal effects of a crude hexane extract of A. annua against A. aegypti, Anopheles sinensis and C. quinquefasciatus (Cheah et al, 2013).…”

mentioning

confidence: 99%

Chemical composition and larvicidal activity of essential oils of three Artemisia species

Seixas

Demuner

Barbosa

et al. 2022

J Applied Entomology

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Aedes aegypti L. (Diptera: Culicidae) is a vector for serious diseases in tropical regions. This pest is mainly controlled by commercial larvicides but the application of such products has led to environmental problems. Essential oils (EO) have been consistently reported as molecules with insecticidal activity and can be used to produce more environmentally friendly larvicides in the control of A. aegypti. In this study, the larvicidal effect of essential oils (EO) from the leaves of three Artemisia species was evaluated against A. aegypti. The oils were obtained from steam distillation and their chemical composition was determined by gas chromatography–mass spectrometry. The EO of Artemisia camphorata was the most active in the screening bioassay and presented LC50 and LC95 of 64.95 and 74.18 μg ml−1, respectively. In addition, we found that germacrene D‐4‐ol was the constituent responsible for the toxicity of this EO. Artemisia camphorata EO and its major constituent, germacrene D‐4‐ol, are promising for the development of natural larvicides against A. aegypti.

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Biosynthesized Gold Nanoparticles Integrated Ointment Base for Repellent Activity Against Aedes aegypti L

Cited by 7 publications

References 36 publications

Mosquito-Borne Diseases and Their Control Strategies: An Overview Focused on Green Synthesized Plant-Based Metallic Nanoparticles

Mosquito-Borne Diseases and Their Control Strategies: An Overview Focused on Green Synthesized Plant-Based Metallic Nanoparticles

The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

Chemical composition and larvicidal activity of essential oils of three Artemisia species

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