Biosynthesis of some alkaloids of Punica granatum and Withania somnifera

Keogh, Myles F.; O'Donovan, D. G.

doi:10.1039/j39700001792

Cited by 14 publications

(9 citation statements)

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“…It was determined that the fruit rinds contained polyholoside at the rate of 2.58% (Jurkovic et al, 1976;Keogh and Donovan, 1970). In result of pectin-related studies conducted on the fruit rinds, it was revealed that mannose, galactose, rhamnose, arabinose, glucose and galacturonic acid were present in its composition.…”

Section: Polyholosidesmentioning

confidence: 98%

Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Mohammad¹,

Kashani²

2012

J. Med. Plants Res.

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In this report, the chemical composition and pharmacological properties of Punica granatum L. (Punicaceae) have been reviewed. In the past decade, numerous studies on the antioxidant, anticarcinogenic, and anti-inflammatory properties of pomegranate constituents have been published, focusing on treatment and prevention of cancer, cardiovascular disease, diabetes, dental conditions, erectile dysfunction, bacterial infections and antibiotic resistance, and ultraviolet radiation-induced skin damage. Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis and obesity.

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Section: Polyholosidesmentioning

confidence: 98%

Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Mohammad¹,

Kashani²

2012

J. Med. Plants Res.

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“…Radioactive acetate is incorporated into GAs regardless of which species is fed [116][117][118][119]. As is In all three hypotheses the origin of the N-methyl group is via labeled methionine [121].…”

Section: Granatane Alkaloid Biosynthesismentioning

confidence: 99%

“…Radioactive acetate is incorporated into GAs regardless of which species is fed [116][117][118][119]. As is the case with tropane alkaloid biosynthesis, the enzymes involved in the extension and cyclization reactions of granatanes includes a putative polyketide synthase.…”

Section: Granatane Alkaloid Biosynthesismentioning

confidence: 99%

“…The general consensus is that lysine (25) is the starting substrate for the entry into granatane biosynthesis. In several cases, different forms of labeled lysine were found incorporated into the core granatane structure [115][116][117][118][119][120]. Sedum sarmentosum 6-14 C-DL-lysine N-methylpelletierine asymmetrically [117] Sedum sarmentosum 4,5-3 H 2 ,6-14 C-DL-lysine N-methylpelletierine [117] Over the course of studies regarding granatane and piperideine alkaloid biosynthesis, there has been some controversy over the origin of the intermediates in the biosynthetic pathway.…”

Section: Granatane Alkaloid Biosynthesismentioning

confidence: 99%

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Tropane and Granatane Alkaloid Biosynthesis: A Systematic Analysis

et al. 2016

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Abstract:The tropane and granatane alkaloids belong to the larger pyrroline and piperidine classes of plant alkaloids, respectively. Their core structures share common moieties and their scattered distribution among angiosperms suggest that their biosynthesis may share common ancestry in some orders, while they may be independently derived in others. Tropane and granatane alkaloid diversity arises from the myriad modifications occurring to their core ring structures. Throughout much of human history, humans have cultivated tropane-and granatane-producing plants for their medicinal properties. This manuscript will discuss the diversity of their biological and ecological roles as well as what is known about the structural genes and enzymes responsible for their biosynthesis. In addition, modern approaches to producing some pharmaceutically important tropanes via metabolic engineering endeavors are discussed.

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“…New therapies for preventing cancer may be on their way as scientists have identified components in pomegranate juice that inhibit the movement of cancer cells. Use of pomegranate flower extract showed significant reduction in wound area and increased the well-organized bands of collagen, fibroblasts, and few inflammatory cells [9][10][11][12][13][14][15][16][17][18][19][20] . Therefore, with the reference to traditional uses, the present study was undertaken to investigate the effect of two extracts, methanolic and aqueous extracts of the flowers of the fruit on in vitro anti-oxidant and antidiabetic potential and give a scientific rational for its use.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Antioxidant and Anti-Diabetic Potential of Kashmiri Pomegranate (Punica Granatum Linn.) Flower Extract

Rashid¹,

Shafi²

2018

Int. Res. J. Pharm.

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Aim: The aim of the present study was to find the effect of two extracts namely, aqueous and methanolic of Punica granatum L. Flowers on in vitro anti-oxidant and anti-diabetic potential Methods: The antioxidant activity of extracts was monitored using DPPH assay, Reducing power, Nitric oxide radical inhibition assay whereas, phenolic content was estimated using Folin-Ciocalteu,s reagent. In vitro anti diabetic activity was evaluated by their effect on alpha-amylase and non-enzymatic glycosylation of haemoglobin. Alpha-Amylase inhibitory activity of Punica granatum L. Flower extracts were evaluated using Porcine pancreatic alpha-amylase (PPA) with starch as a substrate, whereas, in non-enzymatic glycosylation of haemoglobin Glucose (2%), haemoglobin (0.06%) and Gentamycin (0.02%) solution were prepared in phosphate buffer 0.01 M, pH 7.4, 1 ml each of above solution was mixed. 1 ml of each concentration was added to above mixture. Mixture was incubated in dark at room temperature for 72 hrs. The degree of glycosylation of haemoglobin was measured colorimetrically at 520 nm in which Ascorbic acid was used as standard drug. Results: There was significant anti-oxidant activity. Methanolic extract showed the highest inhibitory activity than aqueous extract. Both the extracts were strong inhibitors of alpha-amylase and non-enzymatic glycosylation of haemoglobin. Discussion: The alpha-amylase and non-enzymatic glycosylation of haemoglobin inhibitory activities of Punica granatum L. Flowers correlated to antioxidant activity and phenolic content of extracts. Conclusion: Punica granatum L. flowers can be effective in treatment of diabetes not only through inhibition of alpha-amylase and non-enzymatic glycosylation of haemoglobin inhibitory activities, but also by its antioxidant effect.

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Biosynthesis of some alkaloids of Punica granatum and Withania somnifera

Cited by 14 publications

References 0 publications

Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Chemical composition of the plant Punica granatum L. (Pomegranate) and its effect on heart and cancer

Tropane and Granatane Alkaloid Biosynthesis: A Systematic Analysis

Evaluation of in Vitro Antioxidant and Anti-Diabetic Potential of Kashmiri Pomegranate (Punica Granatum Linn.) Flower Extract

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