Biosynthesis of silver nanoparticles in collagen gel improves their medical use in periodontitis treatment

Crăciunescu, Oana; Seciu, Ana‐Maria; Mănoiu, Vasile Sorin; Trif, Mihaela; Moisei, Magdalena; Nicu, Alina Ioana; Zarnescu, Otilia

doi:10.1080/02726351.2018.1455780

Cited by 18 publications

(16 citation statements)

References 22 publications

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“…From the literature study, it has been deduced that collagen is one of the most abundant natural animal proteins used for the capping of nanoparticles. Collagen is a widespread structural protein in mammals that is crucial for the formation of tissue and regeneration of organs and helps in maintaining the structural integrity of the extracellular matrix (Vijayakumar and Vaseeharan, 2018;Craciunescu et al, 2019;Municoy et al, 2021). It is the best material extensively used in nanoscience due to its biocompatibility, biodegradation, weak antigenicity, and the property of self-assembly and cross-linkage (Municoy et al, 2021).…”

Section: Proteinsmentioning

confidence: 99%

“…It is the best material extensively used in nanoscience due to its biocompatibility, biodegradation, weak antigenicity, and the property of self-assembly and cross-linkage (Municoy et al, 2021). Using this ability of the collagen, Craciunescu et al (2019) have explained the synthesis of silver nanoparticles via type 1 collagen as a reducing and stabilizing agent. In this method, three different concentrations of AgNO 3 (0.1, 0.5, and 2.5 mM) were mixed with 0.3% (w/w) collagen gel in three variants.…”

Section: Proteinsmentioning

confidence: 99%

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Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Sidhu

Verma

Kaushal

2022

Front. Nanotechnol.

141

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The biomedical properties of nanoparticles have been the area of focus for contemporary science; however, there are issues concerning their long-term toxicities. Recent trends in nanoparticle fabrication and surface manipulation, the use of distinctive biogenic capping agents, have allowed the preparation of nontoxic, surface-functionalized, and monodispersed nanoparticles for medical applications. These capping agents act as stabilizers or binding molecules that prevent agglomeration and steric hindrance, alter the biological activity and surface chemistry, and stabilize the interaction of nanoparticles within the preparation medium. Explicit features of nanoparticles are majorly ascribed to the capping present on their surface. The present review article is an attempt to compile distinctive biological capping agents deployed in the synthesis of metal nanoparticles along with the medical applications of these capped nanoparticles. First, this innovative review highlights the various biogenic capping agents, including biomolecules and biological extracts of plants and microorganisms. Next, the therapeutic applications of capped nanoparticles and the effect of biomolecules on the efficiency of the nanoparticles have been expounded. Finally, challenges and future directions on the use of biological capping agents have been concluded. The goal of the present review article is to provide a comprehensive report to researchers who are looking for alternative biological capping agents for the green synthesis of important metallic nanoparticles.

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Section: Proteinsmentioning

confidence: 99%

Section: Proteinsmentioning

confidence: 99%

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Sidhu

Verma

Kaushal

2022

Front. Nanotechnol.

141

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“…The cytotoxicity results obtained in this work for AgHep-NPs in combination with a fungistatic effect allow for the possibility of developing antifungal-conjugated systems of nanoparticles for periodontitis treatment, which preserve human gingival fibroblasts viability [ 65 ]. They might also be appropriate for denture base resins [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Antifungal and Cytotoxic Evaluation of Photochemically Synthesized Heparin-Coated Gold and Silver Nanoparticles

et al. 2020

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Heparin-based silver nanoparticles (AgHep-NPs) and gold nanoparticles (AuHep-NPs) were produced by a photochemical method using silver nitrate and chloroauric acid as metal precursors and UV light at 254 nm. UV–Vis spectroscopy graphs showed absorption for AgHep-NPs and AuHep-NPs at 420 nm and 530 nm, respectively. TEM revealed a pseudospherical morphology and a small size, corresponding to 10–25 nm for AgHep-NPs and 1.5–7.5 nm for AuHep-NPs. Their antifungal activity against Candida albicans, Issatchenkia orientalis (Candida krusei), and Candida parapsilosis was assessed by the microdilution method. We show that AgHep-NPs were effective in decreasing fungus density, whereas AuHep-NPs were not. Additionally, the viability of human gingival fibroblasts was preserved by both nanoparticle types at a level above 80%, indicating a slight cytotoxicity. These results are potentially useful for applications of the described NPs mainly in dentistry and, to a lesser extent, in other biomedical areas.

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“…This is due, first of all, to their anti-inflammatory and wound-healing activity. In addition, silver nanoparticles stabilized by biopolymers have high biocompatibility with human gingival fibroblasts [ 71 ].…”

Section: Dental Therapy Endodontics and Periodonticsmentioning

confidence: 99%

Polymeric Dental Nanomaterials: Antimicrobial Action

et al. 2022

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This review aims to describe and critically analyze studies published over the past four years on the application of polymeric dental nanomaterials as antimicrobial materials in various fields of dentistry. Nanoparticles are promising antimicrobial additives to restoration materials. According to published data, composites based on silver nanoparticles, zinc(II), titanium(IV), magnesium(II), and copper(II) oxide nanoparticles, chitosan nanoparticles, calcium phosphate or fluoride nanoparticles, and nanodiamonds can be used in dental therapy and endodontics. Composites with nanoparticles of hydroxyapatite and bioactive glass proved to be of low efficiency for application in these fields. The materials applicable in orthodontics include nanodiamonds, silver nanoparticles, titanium(IV) and zinc(II) oxide nanoparticles, bioactive glass, and yttrium(III) fluoride nanoparticles. Composites of silver nanoparticles and zinc(II) oxide nanoparticles are used in periodontics, and nanodiamonds and silver, chitosan, and titanium(IV) oxide nanoparticles are employed in dental implantology and dental prosthetics. Composites based on titanium(IV) oxide can also be utilized in maxillofacial surgery to manufacture prostheses. Composites with copper(II) oxide nanoparticles and halloysite nanotubes are promising materials in the field of denture prosthetics. Composites with calcium(II) fluoride or phosphate nanoparticles can be used in therapeutic dentistry for tooth restoration.

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Biosynthesis of silver nanoparticles in collagen gel improves their medical use in periodontitis treatment

Cited by 18 publications

References 22 publications

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Role of Biogenic Capping Agents in the Synthesis of Metallic Nanoparticles and Evaluation of Their Therapeutic Potential

Antifungal and Cytotoxic Evaluation of Photochemically Synthesized Heparin-Coated Gold and Silver Nanoparticles

Polymeric Dental Nanomaterials: Antimicrobial Action

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