Biosynthesis of selenium nanoparticles using combinations of plant extracts and their antibacterial activity

Souza, Lucas Marcelino dos Santos; Dibo, Miriam; Puño-Sarmiento, Juan; Seabra, Amedea B.; Medeiros, Leonardo Pinto; Lourenço, Isabella M.; Kobayashi, Renata Katsuko Takayama; Nakazato, Gerson

doi:10.1016/j.crgsc.2022.100303

Cited by 24 publications

(5 citation statements)

References 64 publications

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“…As previously depicted, phytosynthesized SeNPs (diameter of 23.2 nm) coated by chitosan (20 μg ml −1 ) could inhibit L. monocytogenes with zone diameter of 17.2 mm in diffusion test [69], while bio-SeNPs (particle diameter of 50-200 nm) synthesized by Moringa oleifera extract at the concentration of 700 μg ml −1 displayed an inhibitory diameter of 14.7 mm [70]. However, for E. coli species, while some works reported on E. coli inhibition at SeNP concentrations of 100 μg ml −1 and 950 μg ml −1 with diameter of 9 mm and 19 mm respectively [71,72], the others described the resistance of E. coli treated with these nanoparticles [9]. In brief, in agreement with previous studies, the antibacterial activity of our SeNPs was shown against E. coli and L. monocytogenes in agar well-diffusion assay; however when compared with those reports, this activity was expressed lower (d < 12 mm).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, the antibacterial activity of SeNPs has also been reported in former studies. Particularly, SeNPs could inhibit the growth of Vibrio parahaemolyticus, Staphylococcus areus, Enterococcus faecalis, Pseudomonas aeruginosa, etc [9][10][11][12]. The increase in antibiotic resistance becomes a major challenge for clinical infection treatments, thereby posing a demand for novel antibiotic development.…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Kiet,

Thi Bich Ngoc,

Thi Thanh Ngoc

et al. 2023

Mater. Res. Express

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Selenium nanoparticles (SeNPs) attract more and more interest due to good bioavailability and low toxicity, accompanied by various bioactivities consisting of antimicrobial, antioxidant, and anticancer activity. SeNPs could be generated by physical, chemical, or biological methods and their potential depends on the particle diameter, homogeneity, coating agents, etc Up to now, there has been no previous work reporting on the activities of SeNPs produced by electron beam yet. In our work, SeNPs created by electron beam (SeNP/EB) or gamma irradiation (SeNP/G), stabilized by gum arabic were evaluated for the anticancer capacity by MTT assay, the antioxidant activity by DPPH radical scavenging assay, and the antibacterial ability by agar well diffusion assay. The results showed that SeNP/EB and SeNP/G displayed growth inhibition on HeLa cervical cancer cells with IC50 values of 2.83 and 1.54 μg ml−1, while the values on MCF7 breast cancer cells were 27.70 and 38.80 μg ml−1 respectively. The SeNPs affected HeLa cancer cells more selectively than normal fibroblasts as evidenced by the high selectivity index of 7.98 and 26.25. Notably, the results demonstrated that SeNP/G is much safer than SeNP/EB when applying for cancer treatment in the future. Regarding the DPPH assay, SeNPs of both synthetic methods exhibited potential IC50 values (13.5 and 12 μg ml−1) compared with that of ascorbic acid (8.4 μg ml−1). In comparison to previous studies, our results sugessted that gamma and electron beam irradiation methods, accompanied by coating with gum arabic could be novel approaches in SeNP synthesis to enhance the antioxidant activity of the SeNPs. Besides, SeNPs also caused an inhibition towards Listeria monocytogenes and Escherichia coli, which was verified by the inhibition-zone diameter of approximately 8–12 mm, through inducing oxidative stress in bacterial cells. In conclusion, along with the advantages of physical methods such as time-saving, eco-friendly processes, SeNPs in our work could be a promising candidate for the research and development of healthcare products.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Kiet,

Thi Bich Ngoc,

Thi Thanh Ngoc

et al. 2023

Mater. Res. Express

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“…The antibacterial activity of selenium compounds is attributed to the generation of free radicals, including Se oxyanions [ 501 ]. These novel active products might constitute a solution to the emerging drug-resistant microorganisms that are considered to be a great current health concern [ 62 , 502 , 503 , 504 ]. The unique antibacterial effect of biosynthesized SeNPs has been extensively explored on the basis of morphological and structural changes in the bacterial cells [ 160 , 316 , 490 , 491 , 495 ].…”

Section: Biomedical Applications Of Biogenic Selenium Nanoparticlesmentioning

confidence: 99%

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

et al. 2023

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Selenium is an important dietary supplement and an essential trace element incorporated into selenoproteins with growth-modulating properties and cytotoxic mechanisms of action. However, different compounds of selenium usually possess a narrow nutritional or therapeutic window with a low degree of absorption and delicate safety margins, depending on the dose and the chemical form in which they are provided to the organism. Hence, selenium nanoparticles (SeNPs) are emerging as a novel therapeutic and diagnostic platform with decreased toxicity and the capacity to enhance the biological properties of Se-based compounds. Consistent with the exciting possibilities offered by nanotechnology in the diagnosis, treatment, and prevention of diseases, SeNPs are useful tools in current biomedical research with exceptional benefits as potential therapeutics, with enhanced bioavailability, improved targeting, and effectiveness against oxidative stress and inflammation-mediated disorders. In view of the need for developing eco-friendly, inexpensive, simple, and high-throughput biomedical agents that can also ally with theranostic purposes and exhibit negligible side effects, biogenic SeNPs are receiving special attention. The present manuscript aims to be a reference in its kind by providing the readership with a thorough and comprehensive review that emphasizes the current, yet expanding, possibilities offered by biogenic SeNPs in the biomedical field and the promise they hold among selenium-derived products to, eventually, elicit future developments. First, the present review recalls the physiological importance of selenium as an oligo-element and introduces the unique biological, physicochemical, optoelectronic, and catalytic properties of Se nanomaterials. Then, it addresses the significance of nanosizing on pharmacological activity (pharmacokinetics and pharmacodynamics) and cellular interactions of SeNPs. Importantly, it discusses in detail the role of biosynthesized SeNPs as innovative theranostic agents for personalized nanomedicine-based therapies. Finally, this review explores the role of biogenic SeNPs in the ongoing context of the SARS-CoV-2 pandemic and presents key prospects in translational nanomedicine.

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“…A recent article explored the antimicrobial activity of synthesized SeNP (245-321 nm) using extract of Allium cepa, Malpighia emarginata, and Gymnanthemum amygdalinum against gram-positive resistant pathogens, like Streptococcus agalactiae, S. aureus, and MRSA. It suggested that SeNP could be a promising option in the treatment of MDR bacteria with high efficacy along with low cytotoxicity in red blood cell [52].…”

Section: Nanoparticles (Nps)mentioning

confidence: 99%

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

et al. 2022

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There are several bacteria called superbugs that are resistant to multiple antibiotics which can be life threatening specially for critically ill and hospitalized patients. This article provides up-to-date treatment strategies employed against some major superbugs, like methicillin-resistant Staphylococcus aureus, carbapenem-resistant Enterobacteriaceae, vancomycin-resistant Enterococcus, multidrug-resistant Pseudomonas aeruginosa, and multidrug-resistant Escherichia coli. The pathogen-directed therapeutics decrease the toxicity of bacteria by altering their virulence factors by specific processes. On the other hand, the host-directed therapeutics limits these superbugs by modulating immune cells, enhancing host cell functions, and modifying disease pathology. Several new antibiotics against the global priority superbugs are coming to the market or are in the clinical development phase. Medicinal plants possessing potent secondary metabolites can play a key role in the treatment against these superbugs. Nanotechnology has also emerged as a promising option for combatting them. There is urgent need to continuously figure out the best possible treatment strategy against these superbugs as resistance can also be developed against the new and upcoming antibiotics in future. Rational use of antibiotics and maintenance of proper hygiene must be practiced among patients.

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Biosynthesis of selenium nanoparticles using combinations of plant extracts and their antibacterial activity

Cited by 24 publications

References 64 publications

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Therapeutic potential of electron beam and gamma irradiation synthesized selenium nanoparticles for health care

Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Current Treatment Strategies Against Multidrug-Resistant Bacteria: A Review

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