Biosynthesis of ribose and desoxyribose in Escherichia coli

Bagatell, Fillmore K.; Wright, Elmer W.; Sable, Henry Z.

doi:10.1016/0006-3002(58)90459-1

Cited by 26 publications

(17 citation statements)

References 13 publications

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“…The oxidation of glucose, however, is preferentially involved in ribose formation (199 ). In these experiments (198,199) the labelling pat terns of deoxyribose and ribose were essentially the same, suggesting synthesis of the two sugars via the same pathway. Reichard (200 ) presented further evidence which indicated that the conversion of ribose to deoxy ribose proceeds in chicken embryos on the nucleotide level without cleavage of the glucoside bond.…”

Section: Pentose Phosphate Pathway Ann Related Metabolic Processesmentioning

confidence: 72%

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Carbohydrate Metabolism

Holzer¹

1959

Annu. Rev. Biochem.

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The following abbreviations are used: A CTH for adrenocorticotropic hormone; ADP for adenosine diphosphate; AMP for adenosine diphosphate; ATP for adenosine triphosphate; DPN for oxidized diphosphopyridine nucleotide; DPNH for reduced diphosphopyridine nucleotide; TPN for oxidized triphosphopyridine nucleotide; TPNH for reduced triphosphopyridine nucleotide; UDP for uridine diphosphate; UMP for uridine monophosphate; UTP for uridine triphosphate. • The author is grateful to Dr. H.-J. Boltze for the translation. 171Annu. Rev. Biochem. 1959.28:171-222. Downloaded from www.annualreviews.org Access provided by University of California -San Francisco UCSF on 02/04/15. For personal use only. Quick links to online content Further ANNUAL REVIEWSIn pancreatic j uice of the rat, the concentration of a-amylase is often so high that the enzyme crystallizes spontaneously (14).Cellulose metabolism has been investigated in a variety of molds and bacteria [(15 to 23); for a summary see (24)]. According to Hash & King (19,20), various �-glucosidases are present in the fungus Myrothecium verrucaria, the specificity of which is dependent on the chain length of the substrate. Cellobiose was not found to be an obligatory precursor of glucose in cellulose breakdown. "Cellulose dextrins" (hexasaccharides, etc.) may be formed from cellobiose by transglucosidation. High-speed-centrifuged par ticles from Acetobacter xylinum were shown by Glaser (21) to contain an enzyme which produces cellulose from UDP-glucose. Similar to glycogen synthesis from UDP-gl�cose a primer is required, such as cellodextrins.In various grasses, structure, synthesis, and breakdown of polyfructosans have been investigated in their dependence upon various, particularly sea sonal conditions by Schlubach (25). Avigad & Feingold (26) investigated the fructosides produced ' from sucrose by a corynebacterium. For the synthesis of hyaluronic acid in streptococci, it has been reported by Markovitz et al. (27) that glucose is a precursor of the glucuronic acid and glucosamine moieties. Tritiated UDP-glucuronic acid together with UDP-N-acetyl glucosamine, ATP, and N-acetyl glucosamine-l-phosphate were incubated with strain A streptococci and found to produce appreciable Annu. Rev. Biochem. 1959.28:171-222. Downloaded from www.annualreviews.org Access provided by University of California -San Francisco UCSF on 02/04/15. For personal use only. CARBOHYDRATE METABOLISM 173 amounts of hyaluronic acid. This indicates that the synthesis of hyaluronic acid is very likely to occur via the UDP compounds. The occurrence in group A streptococci of the UDP compounds mentioned has been ascertained chromatographically (28).Glaser & Brown (29) reported that the formation of chitin in a cell-free preparation from Neurospora crassa utilizes UDP-N-acetyl glucosamine, and requires an acetyl glucosamine polymer as a primer:UDP-acetyl glucosamine + (acetyl glucosamine),,� UDP + (acetyl g!ucosamine)n-t1 (2) The decomposition of chitin has been investigated by Berger & Reynolds (30) with a chiti...

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Section: Pentose Phosphate Pathway Ann Related Metabolic Processesmentioning

confidence: 72%

“…Bagatell et al (198) and Bernstein & Sweet (199 ) have shown in experi ments with labelled hexoses that in E. coli ribose is synthesized by both pathways. The oxidation of glucose, however, is preferentially involved in ribose formation (199 ).…”

Section: Pentose Phosphate Pathway Ann Related Metabolic Processesmentioning

confidence: 99%

Carbohydrate Metabolism

Holzer¹

1959

Annu. Rev. Biochem.

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“…[14C]Glucose is transformed into the ribose moiety of AIR via a pentose phosphate shunt in E. coli cells (14). Table 3 shows that [U-14C]glucose was incorporated into the pyrimidine moiety of thiamin with 14.3-fold dilution of the specific activity (as for the in corporation of two carbon atoms from glucose).…”

Section: And Discussionmentioning

confidence: 99%

Precursor of carbon atom five and hydroxymethyl carbon atom of the pyrimidine moiety of thiamin in Escherichia coli.

Yamada

Kumaoka

1983

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…The principal object of the present work was to elucidate some of the factors which govern the selection of one or the other of the biosynthetic pathways. In addition it appeared of interest to extend the finding of Bagatell et al (1958Bagatell et al ( , 1959) and of Bernstein and Sweet (1958) who found that ribose and deoxyribose have identical labeling patterns and therefore concluded that these two pentoses probably have a common origin.…”

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confidence: 88%

BIOSYNTHESIS OF PENTOSES IN ESCHERICHIA COLI

1961

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Previous studies have shown that Escherichia coli possesses two principal pathways for the biosynthesis of pentose from hexose. The best known involves the decarboxylation of 6-phosphogluconate to ribulose 5-phosphate. This is the principal pathway in E. coli grown on glucose (Lanning and Cohen, 1954; Bernstein, 1956). This pathway will be referred to as the oxidative pathway. (The term oxidative pathway is used here to describe the formation of pentose by the oxidative decarboxylation of 6-phosphogluconate and excludes any resynthesis by a complete pentose cycle. The stoichiometry is: 3 hexose + oxygen 3 pentose + 3 CO2. The term transketolasetransaldolase pathway is used here to indicate nonoxidative synthesis of pentose from hexose,

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Biosynthesis of ribose and desoxyribose in Escherichia coli

Cited by 26 publications

References 13 publications

Carbohydrate Metabolism

Carbohydrate Metabolism

Precursor of carbon atom five and hydroxymethyl carbon atom of the pyrimidine moiety of thiamin in Escherichia coli.

BIOSYNTHESIS OF PENTOSES IN ESCHERICHIA COLI

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