Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems

Capecchi, Eliana; Piccinino, Davide; Nascimben, Chiara; Tomaino, Elisabetta; Ceccotti Vlas, Natalia; Gabellone, Sofia; Saladino, Raffaele

doi:10.3390/ijms24109044

Cited by 3 publications

(4 citation statements)

References 57 publications

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“…Multifunctional drug delivery following biomaterials, especially natural polymers that can be combined in therapeutic approaches to oral diseases, has a promising perspective. Renewable polyphenols, such as lignin, may be applied for the encapsulation and controlled release of low-stable natural substances [ 31 ]. Examples of the encapsulation of bioactive natural substances inside lignin nanoparticles were reported, including the encapsulation of resveratrol, curcumin, and ascorbic acid esters such as 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate [ 31 ].…”

Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

“…Renewable polyphenols, such as lignin, may be applied for the encapsulation and controlled release of low-stable natural substances [ 31 ]. Examples of the encapsulation of bioactive natural substances inside lignin nanoparticles were reported, including the encapsulation of resveratrol, curcumin, and ascorbic acid esters such as 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate [ 31 ]. New drug delivery systems need to be developed for better delivery and controlled release, requiring the interdisciplinary collaboration of chemists, biologists, pharmaceuticals, engineers, and doctors requiring constant rethinking and redesigning of formulations to include new bio-active products [ 6 ].…”

Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

“…Therefore, water-soluble and water-insoluble biodegradable polymers are often used in CDDS. Examples of the polymers used in CDDS are listed in Table 5 [ 31 , 99 , 100 , 101 , 102 ].…”

Section: Controlled Drug Delivery Systemsmentioning

confidence: 99%

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Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

et al. 2023

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Cancer is one of the major diseases leading to death worldwide, and the fight against the disease is still challenging. Cancer diseases are usually associated with increased oxidative stress and the accumulation of reactive oxygen and nitrogen species as a result of metabolic alterations or signaling aberrations. While numerous antioxidants exhibit potential therapeutic properties, their clinical efficiency against cancer is limited and even unproven. Conventional anticancer antioxidants and drugs have, among others, the great disadvantage of low bioavailability, poor targeting efficiency, and serious side effects, constraining their use in the fight against diseases. Here, we review the rationale for and recent advances in potential delivery systems that could eventually be employed in clinical research on antioxidant therapy in cancer. We also review some of the various strategies aimed at enhancing the solubility of poorly water-soluble active drugs, including engineered delivery systems such as lipid-based, polymeric, and inorganic formulations. The use of cyclodextrins, micro- and nanoemulsions, and thermosensitive smart liposomes as useful systems for the delivery and release of poorly aqueous-soluble drugs, improving their bioactivity and stability, is also addressed. We also provide some details on their formulation processes and their use in a variety of medical applications. Finally, we briefly cover a case study specifically focused on the use of delivery systems to minimize oral cancer and associated dental problems.

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Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

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Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

et al. 2023

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“…Lignin-based NPs successfully demonstrated the ability to encapsulate ascorbic acid (AA; can act as antioxidant additive to contrast skin aging processes and to protect the cell against photo-damage) in order to improve stability and antioxidant activity against temperature and pH-dependent degradation [250]. An AA ester was synthesized and was efficiently encapsulated inside NPs from KL by a solvent shifting procedure (KL and AA derivatives were dissolved in dimethyl isosorbide; after addition of water NPs precipitated).…”

Section: Lignin-based Nanoparticlesmentioning

confidence: 99%

Lignin, the Lignification Process, and Advanced, Lignin-Based Materials

Balk

Sofia

Neffe

et al. 2023

IJMS

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At a time when environmental considerations are increasingly pushing for the application of circular economy concepts in materials science, lignin stands out as an under-used but promising and environmentally benign building block. This review focuses (A) on understanding what we mean with lignin, i.e., where it can be found and how it is produced in plants, devoting particular attention to the identity of lignols (including ferulates that are instrumental for integrating lignin with cell wall polysaccharides) and to the details of their coupling reactions and (B) on providing an overview how lignin can actually be employed as a component of materials in healthcare and energy applications, finally paying specific attention to the use of lignin in the development of organic shape-memory materials.

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One‐Pot Synthesis of (S)‐Flavanones by a Double‐Face Promiscuous Chemo‐Enzymatic Cascade of Lipases

Ubertini,

Capecchi,

Tomaino

et al. 2024

ChemCatChem

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The one‐pot stereoselective synthesis of (S)‐flavanones from 2′‐hydroxyacetophenone and substituted aromatic aldehydes was obtained by a double‐face promiscuous chemo‐enzymatic cascade of porcine pancreas and Mucor javanicus lipases. The reaction pathway comprises: A) cross‐aldol condensation catalysed by porcine pancreas lipase to yield chalcone intermediates; B) unprecedented intramolecular oxa‐Michael addition of chalcone intermediates to (S)‐flavanones. Mucor javanicus lipase was the most effective enzyme in step B. Imidazole and 2‐methylimidazole were studied as additive in order to improve the efficacy of the overall transformation. The sustainability of the chemo‐enzymatic cascade was increased by immobilization of lipases on cross‐linked hydroxy‐methylated kraft lignin nanoparticles, by use of concanavalin A. Immobilization conferred considerable stability and reusability at the system for 4 runs. Noteworthy, the reaction mixture was significantly enriched in (S)‐flavanones under both homogeneous and heterogeneous conditions. Computational studies encompassing docking and molecular dynamic analyses showed the role played by evolutionary conserved oxyanion holes and catalytic triad of Mucor javanicus lipase in the stereocontrol of the intra‐molecular oxa‐Michael addition.

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Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems

Cited by 3 publications

References 57 publications

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

Lignin, the Lignification Process, and Advanced, Lignin-Based Materials

One‐Pot Synthesis of (S)‐Flavanones by a Double‐Face Promiscuous Chemo‐Enzymatic Cascade of Lipases

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