Biosynthesis of Nicotinic Acid by Mycobacterium tuberculosis

Nicotinamide adenine dinucleotide biosynthesis and pyridine nucleotide cycle metabolism in microbial systems.

“…The pathway of degradation from NAD to NAm, however, varies among different species. A majority of the eucaryotic species examined contain NAD glycohydrolase (2,40,57,92,108,120), which catalyzes the following reaction: NAD+--NAm + adenosine 5'-diphosphate-ribose Figure 8 illustrates the five-membered PNC (PNC V) which uses this enzymatic activity to cleave NAD for recycling. NAD glycohydrolase is relatively rare in procaryotic systems.…”

Niacin Biosynthesis in Plants

“…However, a different pathway, one involving glyceraldehyde and aspartate (Fig. 2), was shown to exist in E. coli (Ortega and Brown, 1960;Yanofski, 1954Yanofski, , 1955Dyke, 1965) and Mycobacterium tuberculosis (Albertson and Moat, 1965). Similar implications have also been made regarding Bacillus subtilis (Yanofski, 1954), Microsporum canis (Levit, 1963), and several Xanthomonas, Pseudomonas and Mycobacterium species (Lingens, Vollprecht, and Gildemeister, 1966).…”

“…Role and conversion of quinolinic acid-All workers to date agree that quinolinic acid is a precursor of niacin (Beadle et al, 1947;Henderson, 1949;Yanofsky, 1954Yanofsky, , 1955Ortega and Brown, 1960;Bartnicki-Garcia and Nickerson, 1961;Erge et al, 1962;Goodwin, 1963;Hadwiger et al, 1963;Levit, 1963;Molina, Walker, and Schweigert, 1959;Wilson and Henderson, 1963;Albertson and Moat, 1965;Dyke, 1965;Lingens [Vol. 66 et aI., 1966).…”