Biosynthesis of NanoSilver and Its Effect on Key Genes of Flavonoids and Physicochemical Properties of Viola tricolor L.

Hassanvand, Arefeh; Saadatmand, Sara; Yazdi, H Lari; Iranbakhsh, Alıreza

doi:10.1007/s40995-021-01091-7

Cited by 7 publications

(3 citation statements)

References 58 publications

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“…A comprehensive perception of drugnanocarriers solubility alterations by changing the pH and salt concentration in the variety of organs can be achieved from MDS. In the event of moderately soluble or insoluble drugs, multiple applied carrier molecules are responsible for improving the stability of the drug [113,114]. To calculate the miscibility of pharmaceuticals and carriers compounds, a computational model, is developed [115,116].…”

Section: Molecular Dynamic Simulationmentioning

confidence: 99%

Niosomes: A Novel Targeted Drug Delivery System

Akbarzadeh¹,

Sedaghatnia²,

Bourbour³

et al. 2021

Preprint

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Nanotechnology is making significant transformation to our world, especially in healthcare and the treatment of diseases. It is widely used in different medical applications, such as in treatment and detection. Targeting diseased cell with nanomedicines is one of the numerous applications of nanotechnology. Targeted drug delivery systems for delivering various types of drugs to specific sites are such a dynamic area in pharmaceutical biotechnology and nanotechnology. Compared to conventional drugs, nanomedicines have a higher absorption and bioavailability rate, improving efficacy and minimizing side effects. There are several drug delivery systems including metallic nanoparticles, polymers, liposomes, and microspheres, but one of the most important is the niosomes, which are produced by nonionic surfactants. Because of the amphiphilic nature and structure, hydrophilic or hydrophobic drugs can be loaded into niosome structures. Other compounds, including cholesterol, can also be applied to the niosomes' backbone to rigidize the structure. Several variables such as the type of surfactant in niosome production, the preparation method, and the hydration temperature can affect the structure of the niosomes. Nevertheless, in-silico design of drug delivery formulations requires molecular dynamic simulation tools, molecular docking, and ADME (absorption; distribution; excretion; metabolism) properties, which evaluate physicochemical features of formulation and ADME attitudes before synthesis, investigating the interaction between nano-carriers and specific targets. Hence, experimenting in-vitro and in-vivo is essential. In this review, the basic aspects of niosomes are described including their structure, characterization, preparation methods, optimization with in-silico tools, factors affecting their formation, and limitations.

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Section: Molecular Dynamic Simulationmentioning

confidence: 99%

Niosomes: A Novel Targeted Drug Delivery System

Akbarzadeh¹,

Sedaghatnia²,

Bourbour³

et al. 2021

Preprint

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“…F3′5′H is the key enzyme for the anthocyanins synthesis that belongs to the cytochrome P450 family [ 3 ], which catalyzes the hydroxylation of the 3′ and 5′ ends of the colorless dihydroflavonol B ring [ 4 ]. The F3′5′H gene is the key to the formation of blue-purple flowers, which also the main type of blue to purple anthocyanins (delphinidin-based anthocyanins) [ 4 , 5 ]. In recent years, F3′5′H gene has become a hot spot for scientists and industrial research, due to many important ornamental flowers such as Rosa rugosa , Dianthus caryophyllus , chrysanthemum , Dendranthema morifolium lack F3′5′H gene and cannot produce blue and purple flowers [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, true blue flowers are rare in nature, which only appear in selected species such as morning glory and delphinium [ 7 ]. It is the research focus of molecular breeding of blue flowers on the regulation mechanism of F3′5′H gene, which is also one of the research hotspots of flower breeding in the world [ 5 ]. At present, the F3′5′H gene has been cloned in many flowers such as Iris halophila, Dendrobium moniliforme , Salvia Miltiorrhiza [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Cloning and Expression Analysis of Flavonoid 3′, 5′-Hydroxylase Gene from Brunfelsia acuminata

Cao

Debnath

et al. 2021

Genes

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The full-length cDNA sequence of F3′5′H gene from the Brunfelsia acuminata was obtained by RT-PCR and RACE, whose GenBank accession number is JQ678765. The sequence contains a 1521 bp open reading frame, 120 bp 5′UTR and 61 bp 3′UTR, encoding a total of 506 amino acids. The molecular mass of the predicted protein is 56.47 kDa with an estimated pI of 8.78, respectively. Sequence alignment showed that the amino acid sequence of F3′5′H was 91%, 87% and 84% with that of Petunia × hybrida, Nierembergia sp., Solanum tuberosum, respectively. Real-time quantitative PCR analysis showed that the expression of F3′5′H gene was different in petals of different days, which was the highest expression level on day 0 and significantly higher than other days. The results indicated that F3′5′H might play key role in flower color regulation and provide a theoretical reference for blue flower molecular breeding.

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