Biosynthesis of mycosporines: Mycosporine glutaminol in Trichothecium roseum

Favre-Bonvin, Jean; Bernillon, Jacques; Salin, N.; Arpin, N.

doi:10.1016/s0031-9422(00)83866-2

Cited by 144 publications

(87 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, UV-absorbing mycosporine-like amino acids (MAAs) that protect against the direct and indirect damaging effects of solar UV radiation have been isolated from diverse free-living algae and marine invertebrate-algal symbioses, including zooxanthellate cnidarians. MAAs are putatively synthesized via a branch of the shikimic acid pathway at 3-dehydroquinate (5)(6)(7)(8). Therefore, the expectation is that MAAs in phototrophic symbioses are produced by the microbial partner, or obtained from the diet, because metazoans reputedly lack the shikimate pathway to synthesize ''essential'' aromatic compounds (5,9,10).…”

mentioning

confidence: 99%

Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis , have microbial origins

Starčević

Akthar

Dunlap

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

121

117

View full text Add to dashboard Cite

The shikimic acid pathway is responsible for the biosynthesis of many aromatic compounds by a broad range of organisms, including bacteria, fungi, plants, and some protozoans. Animals are considered to lack this pathway, as evinced by their dietary requirement for shikimate-derived aromatic amino acids. We challenge the universality of this traditional view in this report of genes encoding enzymes for the shikimate pathway in an animal, the starlet sea anemone Nematostella vectensis. Molecular evidence establishes horizontal transfer of ancestral genes of the shikimic acid pathway into the N. vectensis genome from both bacterial and eukaryotic (dinoflagellate) donors. Bioinformatic analysis also reveals four genes that are closely related to those of Tenacibaculum sp. MED152, raising speculation for the existence of a previously unsuspected bacterial symbiont. Indeed, the genome of the holobiont (i.e., the entity consisting of the host and its symbionts) comprises a high content of Tenacibaculum-like gene orthologs, including a 16S rRNA sequence that establishes the phylogenetic position of this associate to be within the family Flavobacteriaceae. These results provide a complementary view for the biogenesis of shikimate-related metabolites in marine Cnidaria as a ''shared metabolic adaptation'' between the partners. symbiosis ͉ Tenacibaculum ͉ Cnidaria

show abstract

mentioning

confidence: 99%

Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis , have microbial origins

Starčević

Akthar

Dunlap

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

121

117

View full text Add to dashboard Cite

show abstract

“…There are two biosynthesis pathways of MAAs. First MAAs biosynthesis pathway is the Shikimate pathway [29] which is known as the synthesis way of aromatic amino acids. Second MAAs biosynthesis pathway is pentose phosphate pathway [30].…”

Section: Mycosporin-like Amino Acidsmentioning

confidence: 99%

Can Fortified Bifidobacterium with Mycosporin-like Amino Acid be a New Insight for Neurological Disease' s Treatment?

Bozkurt¹,

Kara²

2018

Autism Open Access

View full text Add to dashboard Cite

Gastrointestinal microbiota includes bacteria, archaea, viruses, fungi and other eukaryotes. The genus Bifidobacterium is considered the dominant once; it has an important role on immunologic, hormonal and metabolic homeostasis of the host. Recent studies demonstrated that the Mycosporin-like Amino Acids (MAAs) had prebiotic effects and they modulated host immunity by regulating the proliferation and differentiation of intestinal epithelial cells, macrophage and lymphocytes. Also MAAs modulate NF-κB and tryptophan metabolism. Modulation NF-κB and tryptophan metabolism induced a beneficial effect on central nervous cascade. The safety of Bifidobacterium species is known; although they do not produce MAAs, their presence is required for immunological response continuity of intestine. Thereby we hypothesize that if we could create Bifidobacteria species producing MAAs via genetic engineering; they might have stronger immuno-stimulatory properties and might be used as more potent pharmacological agents in neurological diseases secondary to impaired microbiota.

show abstract

“…One such compound, mycosporine, identified in fungi was found to have a role in UV-induced sporulation [7][8][9][10]. Mycosporine like amino acids (MAAs) are found in marine organisms, from bacteria to fish [11,12] and in terrestrial microorganisms like fungi [13]. High concentrations of MAAs are found in epilithiccyanobacterial or algal mats [14,15].…”

Section: Introductionmentioning

confidence: 99%

Characterization of PhotoprotectiveCompounds in Marine Zooplankton of the Southwest Coast of India: An Ecological Perspective

Nallathambi¹,

S²,

Vardhan³

et al. 2012

View full text Add to dashboard Cite

Inthe marine environment, organisms are under threat due to several environmental fluctuations such as ultraviolet (UV) radiation, coastal pollution etc. However, it is encouraging to note that the marine organisms try to protect themselves from UV-radiation by synthesizing photprotective compounds. Since phytoplankton can synthesize the UV-protecective compounds and are grazed by zooplankton, we investigated the presence of photoprotective compounds in zooplankton. In this context, a study has been conducted for the first time in the shelf waters of the southwest coast of Arabian Sea, India for the characterization of photoprotective compounds in the zooplankton community. The study revealed the presence of photoprotective compounds, such asporphyra and palythine in the zooplankton community of all the stations, in addition to mycosporine glycine, in the polluted waters of the stations,Veli, Neendakari and Cochin.

show abstract

Biosynthesis of mycosporines: Mycosporine glutaminol in Trichothecium roseum

Cited by 144 publications

References 12 publications

Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis , have microbial origins

Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis , have microbial origins

Can Fortified Bifidobacterium with Mycosporin-like Amino Acid be a New Insight for Neurological Disease' s Treatment?

Characterization of PhotoprotectiveCompounds in Marine Zooplankton of the Southwest Coast of India: An Ecological Perspective

Contact Info

Product

Resources

About