Biosynthesis of CuO nanoparticles and synergistic antibacterial activity using mint leaf extract

Aziz, Wisam J.; Abid, Muslim A.; Hussein, Emad H.

doi:10.1080/10667857.2019.1692163

Cited by 35 publications

(12 citation statements)

References 26 publications

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“…As indicated by XRD data in Figure B, the CuO-NPs generated by the reduction of Cu + ions from the leaf extract are crystalline in nature. Before the XRD examination, the CuO-NPs were centrifuged many times and recollected in sterile distilled water, as stated above in the Biosynthesis of Copper Nanoparticles section, to eliminate any material that may ignite . The appearance of structural peaks in XRD models indicates that the green synthesis of CuO-NPs is monoclinic space crystalline with an average crystal size of 22.4 nm. , …”

Section: Resultsmentioning

confidence: 99%

“…33 The appearance of structural peaks in XRD models indicates that the green synthesis of CuO-NPs is monoclinic space crystalline with an average crystal size of 22.4 nm. 33,34 FTIR Analysis. The possible role of B. monnieri biomolecule functional groups in the capping and reduction of CuO-NPs was investigated using FTIR spectroscopy.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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In this work, an ecofriendly approach for biogenic production of copper oxide nanoparticles (CuO-NPs) was proposed by utilizing the Bacopa monnieri leaf extract as a reducing and stabilizing agent. The synthesis of CuO-NPs was instantly confirmed by a shift in the color of the copper solution from blue to dark gray. The use of UV−visible spectroscopy revealed a strong narrow peak at 535 nm, confirming the existence of monoclinic-shaped nanoparticles. The average size of CuO-NPs was 34.4 nm, according to scanning electron microscopy and transmission electron microscopy studies. The pristine crystalline nature of CuO-NPs was confirmed by X-ray diffraction. The monoclinic form of CuO-NPs with a crystallite size of 22 nm was determined by the sharp narrow peaks corresponding to 273, 541, 698, 684, and 366 Bragg's planes at different 2θ values. The presence of different reducing metabolites on the surface of CuO was shown by Fourier transform infrared analysis. The biological efficacy of CuO-NPs was tested against Helicobacter felis, Helicobacter suis, Helicobacter salomonis. and Helicobacter bizzozeronii. H. suis was the most susceptible strain with an inhibition zone of 15.84 ± 0.89 mm at 5 mg/mL of NPs, while the most tolerant strain was H. bizzozeronii with a 13.11 ± 0.83 mm of inhibition zone. In in vivo analgesic activity, CuO-NPs showed superior efficiency compared to controls. The maximum latency time observed was 7.14 ± 0.12 s at a dose level of 400 mg/kg after 90 min, followed by 5.21 ± 0.29 s at 400 mg/kg after 60 min, demonstrating 65 and 61% of analgesia, respectively. Diclofenac sodium was used as a standard with a latency time of 8.6 ± 0.23 s. The results observed in the rat paw edema assays showed a significant inhibitory activity of the plant-mediated CuO-NPs. The percentage inhibition of edema was 74% after 48 h for the group treated with CuO-NPs compared to the control group treated with diclofenac (100 mg/kg) with 24% edema inhibition. The solution of CuO-NPs produced 82% inhibition of edema after 21 days when compared with that of the standard drug diclofenac (73%). CuO-NPs vividly lowered glucose levels in STZ-induced diabetic mice, according to our findings. Blood glucose levels were reduced by about 33.66 and 32.19% in CuO-NP and (CuO-NP + insulin) groups of mice, respectively. From the abovementioned calculations, we can easily conclude that B. monnieri-synthesized CuO-NPs will be a potential antibacterial, anti-diabetic, and anti-inflammatory agent on in vivo and in vitro basis.

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Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

et al. 2022

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“…Figure 3 a indicates a noticeable peak at 325 nm due to the inter band transition of the core electrons of the CuO NPs. Aziz et al 42 used also mint leaf extract for the synthesis of CuO NPs and detected its absorption peak at 346 nm. Sankar et al 37 detected a strong absorbance peak between 250 and 300 nm suggesting the formation of CuO NPs.…”

Section: Resultsmentioning

confidence: 99%

Green copper oxide nanoparticles for lead, nickel, and cadmium removal from contaminated water

Mahmoud

Al-Qahtani

Alflaij

et al. 2021

Sci Rep

134

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Environmentally friendly copper oxide nanoparticles (CuO NPs) were prepared with a green synthesis route without using hazardous chemicals. Hence, the extracts of mint leaves and orange peels were utilized as reducing agents to synthesize CuO NPs-1 and CuO NPs-2, respectively. The synthesized CuO NPs nanoparticles were characterized using scanning electron microscopy (SEM), Energy Dispersive X-ray Analysis (EDX), BET surface area, Ultraviolet–Visible spectroscopy (UV–Vis), and Fourier Transform Infrared Spectroscopy (FT-IR). Various parameters of batch experiments were considered for the removal of Pb(II), Ni(II), and Cd(II) using the CuO NPs such as nanosorbent dose, contact time, pH, and initial metal concentration. The maximum uptake capacity (qm) of both CuO NPs-1 and CuO NPs-2 followed the order of Pb(II) > Ni(II) > Cd(II). The optimum qm of CuO NPs were 88.80, 54.90, and 15.60 mg g−1 for Pb(II), Ni(II), and Cd(II), respectively and occurred at sorbent dose of 0.33 g L−1 and pH of 6. Furthermore, isotherm and kinetic models were applied to fit the experimental data. Freundlich models (R2 > 0.97) and pseudo-second-order model (R2 > 0.96) were fitted well to the experimental data and the equilibrium of metal adsorption occurred within 60 min.

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“… 37 Green synthesized CuONPs with 22-25 nm crystallite size via mint leaf extract showed 38 and 35 mm IZDs for Bacillus subtilis and E. coli bacteria respectively. 38 Biosynthesized CuONPs by Bacillus sp. FU4 demonstrated IZD of 33±0.57 mm toward E. coli ATCC 25922.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activities of Phytofabricated ZnO and CuO NPs by Mentha pulegium Leaf/flower Mixture Extract against Antibiotic Resistant Bacteria

et al. 2020

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Purpose: In this study, leaf/flower aqueous extract of medicinal plant species Mentha pulegium was used to synthesize ZnO and CuO nanoparticles (NPs) as a cost-effective, one-step, and eco-friendly method. Methods: Physicochemical properties of both metal oxide NPs (MONPs) were determined by UV-Vis spectroscopy, X-Ray Diffraction (XRD), Fourier-Transform Infra-Red (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and Energy Dispersive X-ray (EDX) techniques. Results: Phytofabricated ZnONPs and CuNPs illustrated 65.02±7.55 and 26.92±4.7 nm with antibacterial activities against antibiotic-resistant Escherichia coli and Staphylococcus aureus. Higher antibacterial activities were observed for CuONPs compared with ZnONPs. Conclusion: Large surface area and more reactivity resulted from smaller size as well as higher production of reactive oxygen species (ROS) were considered to antibacterial efficiency of CuONPs against antibiotic-resistant E. coli and S. aureus.

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Biosynthesis of CuO nanoparticles and synergistic antibacterial activity using mint leaf extract

Cited by 35 publications

References 26 publications

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

In Vivo Analgesic, Anti-Inflammatory, and Anti-Diabetic Screening of Bacopa monnieri-Synthesized Copper Oxide Nanoparticles

Green copper oxide nanoparticles for lead, nickel, and cadmium removal from contaminated water

Antibacterial Activities of Phytofabricated ZnO and CuO NPs by Mentha pulegium Leaf/flower Mixture Extract against Antibiotic Resistant Bacteria

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