Biosynthesis of aristolochic acid

Comer, F.; Tiwari, H. P.; Spenser, Ian D.

doi:10.1139/v69-070

Cited by 25 publications

(16 citation statements)

References 12 publications

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“…Comer et al . 13 reported the formation of radioactive aristolochic acid I when [β-14C,15N]-tyrosine was added to Aristolochia sipho . The synthesis pathway of aristolochic acid I is speculated to be tyrosine → tyramine → 4-hydroxy-phenyl-acetaldehyde → (s)-nor-amethoxine → (S)-Nor Laudanine → orientaliue → stephanine → aristolochic acid I, adapted from the literature published by Comer (1969) 14 (Fig.…”

Section: Resultsmentioning

confidence: 99%

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides

Wang

Fang

Yang

et al. 2018

Sci Rep

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Asarum spp. are important medicinal plants that have the potential for use in treating various types of fevers. Aristolochic acid is one of the main toxic compounds present in these plants. To improve our understanding of the biosynthetic pathway of aristolochic acid, we sequenced the transcriptome of the root and leaf tissues of Asarum heterotropoides and performed de novo sequence assembly. The data were stitched together to produce 468,357 transcripts with an N50 of 611 bp. The data were annotated with various databases (RefSeq non-redundant proteins [Nr], Swiss-Prot, Kyoto Encyclopaedia of Genes and Genomes [KEGG], Clusters of Orthologous Groups/EuKaryotic Orthologous Groups [COG/KOG], and Gene Ontology [GO]) and were annotated. There were 205,165 transcripts (43.81%) of differentially expressed genes in the roots and leaves, which were shown to be involved in biosynthesis, transport, and catabolism, and 100 genes in defence mechanisms. Three candidate transcripts (TyrDC1, TyrDC2, and TyrDC3) were discovered in these differential genes. TyrDC may be a key enzyme in the biosynthesis pathway of aristolochic acid identified using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and high-performance liquid chromatography (HPLC). The transcriptome data and analysis presented here lay the foundation for further research into these important medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides

Wang

Fang

Yang

et al. 2018

Sci Rep

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“…However, a biogenetic relationship between aristolochic acids and the aporphine alkaloids has been postulated based on structural similarities. Magnoflorine, an aporphine alkaloid, is associated with aristolochic acids in various Aristolochia species (Comer et al, 1969;Schutteu et al, 1967). An aporphine alkaloid, 4,5dioxoaporphine (24), is found mostly among the Aristolochiaceae family of plants and regarded as possible intermediates of the precursors of aristolochic acids and aristolactams (Kumar et al, 2003).…”

Section: Biosynthesis Of Aristolochic Acidsmentioning

confidence: 99%

“…Similar incidence of substitution was also reported in Hong Kong (Liang et al, 2006). Consequently, patients who took the regimen developed interstitial renal fibrosis and subsequently, end-stage renal disease (Comer et al, 1969). It is also documented that about 5% of the exposed population (patients taking the weight-loss regimen from May 1990 to October 1992) developed renal disease.…”

Section: Nephrotoxicitymentioning

confidence: 99%

Aristolochic acids in herbal medicine: Public health concerns for consumption and poor regulation of botanical products in Nigeria and West Africa

Okhale¹,

Egharevba²,

Okpara³

et al. 2019

J. Med. Plants Res.

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Aristolochic acids are naturally occurring biomolecules found in plants of the genus Aristolochia and Asarum belonging to the family Aristolochiaceae. They are reported to be carcinogenic and nephrotoxic; and are implicated in kidney diseases, aristolochic acid nephropathy (AAN) which may result in kidney failure, other health complications and possibly death. Aristolochic acids are highly genotoxic and are linked to upper urothelial cancer in animals and humans. Some Aristolochia species are used in traditional medicine practice in Nigeria and other West African countries without regard to safety concerns. Several countries, especially in the Western world, have banned the use and importation of herbal products containing aristolochic acids. There is need for warning and strict regulation on the importation and consumption of aristolochic acids-containing botanical products in Nigeria. This study aims to review the availability of aristolochic acids, their toxicity, circulation, as well as the quantitative analytical techniques and regulations. It analyzes the herbal products containing aristolochic acids, and aristolochaceae plants grown in Nigeria in respect to public health implications. It highlights the importance of doing an extensive study on indigenous plants producing aristolochic acids and imported herbal products used as weight loss supplements marketed in Nigeria. There is need to emphasize the labeling of herbal products containing aristolochic acids.

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“…3. The scientific details of aristolochic acids biosynthesis have been reported in several research papers (Schütte et al, 1967;Comer et al, 1969;Sharma et al, 1982;Krumbiegel et al 1987), and recently reviewed (Winkler and Hertweck 2007;Michl et al, 2014;Kumar et al, 2003). The plants of the genera Aristolochia and Asarum became the interesting topic for the phytochemical and pharmaceutical researchers since the discovery of aristolochic acid derivatives.…”

Section: Corallococcus Exiguus Cystobacter Ferrugineus Myxococcus Fmentioning

confidence: 99%

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

Dembitsky¹,

Gloriozova

Poroikov

2015

Phytomedicine

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Biosynthesis of aristolochic acid

Cited by 25 publications

References 12 publications

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides

Aristolochic acids in herbal medicine: Public health concerns for consumption and poor regulation of botanical products in Nigeria and West Africa

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

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