Biosynthesis of Antitumoral and Bactericidal Sanguinarine

García, Víctor Pérez; Valdés, Francisco; Martin, R.R.; Luis, Juan; Afonso, Ana M.; Ayala, Juan H.

doi:10.1155/jbb/2006/63518

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…Seeds of A. mexicana are rich in nonsaturated fatty acids, such as linoleic, oleic, ricinoleic and palmitoleic acids. The presence of Argemone oil in edible mustard oil is probably responsible for outbreaks of epidemic dropsy, a clinical syndrome characterized by oedema, cardiac insufficiency, renal failure and glaucoma, which is attributed to sanguinarine, the main Argemone alkaloid (Garcia et al. , 2006).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and effects of Argemone Mexicana (Papaveraceae) on biodiversity in Ethiopia

Alemayehu¹

2011

African Journal of Ecology

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The prevalence and potentials of Argemone mexicana on biodiversity was assessed at Farta, Gondar and Bahir Dar zuria districts. The study areas were stratified into 100 m by 5 m as roadside, fallow land and farmland transect belts. Its effects as poultry feed component were studied on three poultry breeds. Body weights, abnormalities in appetite, egg production and health were recorded. The results indicated that the mean prevalence of Argemone per transect belt in roadside land (17.41 ± 5.9) was higher than that of fallow land (3.35 ± 0.8) and farmland (2.65 ± 0.8) at Farta district. The number and distribution of native plant species under the shed of A. mexicana in roadside, fallow land and farmland per transect belts were 1.15 ± 1.6, 2.25 ± 1.8 and 1.15 ± 0.5, respectively. The number and distribution of Argemone plants in the roadside land per transect increased by 163.4%, 158.5% and 151.9% from 2006 to 2010 in above respective districts. The mean losses in appetite, body weight and egg production were higher in exotic and cross bred than in indigenous chicken ecotypes. Therefore, A. mexicana had negative impacts on biodiversity, native plant species and when used as animal feed components.

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Section: Discussionmentioning

confidence: 99%

Prevalence and effects of Argemone Mexicana (Papaveraceae) on biodiversity in Ethiopia

Alemayehu¹

2011

African Journal of Ecology

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“…Sanguinarine and chelerythrine are among alkaloids that have been studied the most. Sanguinarine, 13‐methyl[1,3]benzodiooxolo[5,6, c]‐1,3‐dixolo[4,5‐ i ] phenanthradinum, has a wide range of potentially useful medicinal properties, such as antimicrobial, anti‐inflammatory, and antitumor activities (García et al, ). It is listed in the Prestwick Chemical Library that consists of 1,120 Food and Drug Administration‐approved compounds…”

Section: Phytochemistrymentioning

confidence: 99%

Medicinal plants of the genus Macleaya (Macleaya cordata, Macleaya microcarpa): A review of their phytochemistry, pharmacology, and toxicology

Lin

Liang

Huang

et al. 2017

Phytotherapy Research

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In the genus Macleaya, Macleaya cordata and Macleaya microcarpa have been recognized as traditional herbs that are primarily distributed in China, North America, and Europe and have a long history of medicinal usage. These herbs have been long valued and studied for detumescence, detoxification, and insecticidal effect. This review aims to provide comprehensive information on botanical, phytochemical, pharmacological, and toxicological studies on plants in the genus Macleaya. Plants from the genus of Macleaya provide a source of bioactive compounds, primarily alkaloids, with remarkable diversity and complex architectures, thereby having attracted attention from researchers. To date, 291 constituents have been identified and/or isolated from this group. These purified compounds and/or crude extract possess antitumor, anti-inflammatory, insecticidal, and antibacterial activities in addition to certain potential toxicities. Macleaya species hold potential for medicinal applications. However, despite the pharmacological studies on these plants, the mechanisms underlying the biological activities of active ingredients derived from Macleaya have not been thoroughly elucidated to date. Additionally, there is a need for research focusing on in vivo medical effects of Macleaya compounds and, eventually, for clinical trials.

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“…Two potent isoquinoline alkaloids, 8hydroxydihydrosanguinarine and 8-hydroxydihydrochelerythrine, were identified as the major active principles against extended-spectrum b-lactamase-producing strains (Zuo et al, 2011). Sanguinarine has also been incorporated into expectorant mixtures and has a strong bactericidal effect upon gram-positive bacteria, particularly Bacillus anthracis and staphylococci (García et al, 2006). Sanguinarine has also been incorporated into expectorant mixtures and has a strong bactericidal effect upon gram-positive bacteria, particularly Bacillus anthracis and staphylococci (García et al, 2006).…”

Section: Antimicrobial Activitymentioning

confidence: 99%