Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

Méjean, Annick; Paci, G.; Gautier, Valérie; Ploux, Olivier

doi:10.1016/j.toxicon.2014.07.016

Cited by 92 publications

(89 citation statements)

References 42 publications

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“…A less toxic analogue, dihydroanatoxin-a was isolated from different strains of Oscillatoria sp., Phormidium sp. and Cylindrospermum stagnale Bornet & Flahault (Méjean et al, 2014). Evidence for the potent acetylcholinesterase inhibitor anatoxin-a(S) (Onodera et al, 1997) has been found more rarely in Europe: to date, in Denmark and Scotland (Devic et al, 2002).…”

Section: Occurrence Of Cyanobacteria and Cyanotoxins And Methods Formentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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This review aims to summarise the outcomes of some recent European research concerning toxic cyanobacteria and cyanotoxins, with an emphasis on developments within the framework of the CYANOCOST Action: COST Action ES1105, Cyanobacterial Blooms and Toxins in Water Resources: Occurrence, Impacts and Management. Highlights of the Action include phycological and ecological studies, development of advanced techniques for cyanotoxin analysis, elucidation of cyanotoxin modes of action, management techniques to reduce cyanobacterial mass development, and research on methods and practices for cyanotoxin removal during drinking water treatment. The authors have identified a number of gaps in knowledge. Proposed directions for future research on toxic cyanobacteria and cyanotoxins are also discussed.

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Section: Occurrence Of Cyanobacteria and Cyanotoxins And Methods Formentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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“…Comparative genomic analyses show that the genes involved in F 420 biosynthesis and utilization are also found in representatives of the Chloroflexi, Alphaproteobacteria, Betaproteobacteria, and Gammaproteobacteria (30,37), which constitute some of the most dominant taxa in aerated soil ecosystems (147). The occasional references to F 420 -dependent processes in Cyanobacteria are erroneous; these have emerged from authors misattributing F o -dependent processes to F 420 (72,148) or relying on incorrect automated sequence predictions (149). Indeed, F 420 has yet to be chemically identified in any species outside the phyla Euryarchaeota and Actinobacteria.…”

Section: Distributionmentioning

confidence: 99%

Physiology, Biochemistry, and Applications of F₄₂₀- and F_o-Dependent Redox Reactions

Greening

Ahmed

Mohamed

et al. 2016

Microbiol Mol Biol Rev

152

208

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SUMMARY5-Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin, 5-deazaflavins have distinctive and biologically useful electrochemical and photochemical properties as a result of the substitution of N-5 of the isoalloxazine ring for a carbon. 8-Hydroxy-5-deazaflavin (Fo) appears to be used for a single function: as a light-harvesting chromophore for DNA photolyases across the three domains of life. In contrast, its oligoglutamyl derivative F420is a taxonomically restricted but functionally versatile cofactor that facilitates many low-potential two-electron redox reactions. It serves as an essential catabolic cofactor in methanogenic, sulfate-reducing, and likely methanotrophic archaea. It also transforms a wide range of exogenous substrates and endogenous metabolites in aerobic actinobacteria, for example mycobacteria and streptomycetes. In this review, we discuss the physiological roles of F420in microorganisms and the biochemistry of the various oxidoreductases that mediate these roles. Particular focus is placed on the central roles of F420in methanogenic archaea in processes such as substrate oxidation, C1pathways, respiration, and oxygen detoxification. We also describe how two F420-dependent oxidoreductase superfamilies mediate many environmentally and medically important reactions in bacteria, including biosynthesis of tetracycline and pyrrolobenzodiazepine antibiotics by streptomycetes, activation of the prodrugs pretomanid and delamanid byMycobacterium tuberculosis, and degradation of environmental contaminants such as picrate, aflatoxin, and malachite green. The biosynthesis pathways of Foand F420are also detailed. We conclude by considering opportunities to exploit deazaflavin-dependent processes in tuberculosis treatment, methane mitigation, bioremediation, and industrial biocatalysis.

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“…The anatoxins (anatoxin-a, dihydroanatoxin-a and homoanatoxin-a) are a group of neurotoxic alkaloids that potently and irreversibly inhibit acetylcholinesterase within the nerve synapse; which can lead to paralysis and asphyxiation [53,54]. The genes involved in the biosynthesis of these compounds in diverse cyanobacteria have recently been elucidated [55]. These 3 compounds should not be confused with anatoxin-a(s), although they all share a similar mode of action, anatoxin-a(s) is a distinct molecule and the genes involved in its biosynthesis remain unknown.…”

Section: Cyanotoxin Biosynthesismentioning

confidence: 99%

Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction

Otten

Paerl

2015

Curr Envir Health Rpt

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Cyanobacterial-derived water quality impairment issues are a growing concern worldwide. In addition to their ecological impacts, these organisms are prolific producers of bioactive secondary metabolites, many of which are known human intoxicants. To date only a handful of these compounds have been thoroughly studied and their toxicological risks estimated. While there are currently no national guidelines in place to deal with this issue, it is increasingly likely that within the next several years guidelines will be implemented. The intent of this review is to survey all relevant literature pertaining to cyanobacterial harmful algal bloom secondary metabolites, to inform a discussion on how best to manage this global public health threat.

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Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

Cited by 92 publications

References 42 publications

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Physiology, Biochemistry, and Applications of F₄₂₀- and F_o-Dependent Redox Reactions

Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction

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Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

Cited by 92 publications

References 42 publications

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions

Health Effects of Toxic Cyanobacteria in U.S. Drinking and Recreational Waters: Our Current Understanding and Proposed Direction

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Physiology, Biochemistry, and Applications of F₄₂₀- and F_o-Dependent Redox Reactions