Biosynthesis and regulation of terpenoids from basidiomycetes: exploration of new research

Abstract

Basidiomycetes, also known as club fungi, consist of a specific group of fungi. Basidiomycetes produce a large number of secondary metabolites, of which sesquiterpenoids, diterpenoids and triterpenoids are the primary components. However, these terpenoids tend to be present in low amounts, which makes it difficult to meet application requirements. Terpenoid biosynthesis improves the quantity of these secondary metabolites. However, current understanding of the biosynthetic mechanism of terpenoids in basidiomycetes is insufficient. Therefore, this article reviews the latest research on the biosynthesis of terpenoids in basidiomycetes and summarizes the CYP450 involved in the biosynthesis of terpenoids in basidiomycetes. We also propose opportunities and challenges for chassis microbial heterologous production of terpenoids in basidiomycetes and provide a reference basis for the better development of basidiomycete engineering.

Bioactivity of Biomass and Crude Exopolysaccharides Obtained by Controlled Submerged Cultivation of Medicinal Mushroom Trametes versicolor

“…The proper controlled submerged cultivation in an appropriate nutrient medium is a promising approach leading to the increased production of macrofungal biomass and bioactive substances with consistent quality, decreased production time, reduced downstream processing cost, decreased contamination risks and assured sustainability possibility [ 2 , 21 , 22 , 23 , 24 ]. Serious efforts are being made to increase the yield of bioactive metabolites by the optimization of the cultivation medium composition and conditions [ 23 , 25 , 26 , 27 , 28 ], together with exploring the genetic mechanisms of the biosynthetic pathways and their regulation [ 29 ].…”

Draft Genomes of Six Wild Poisonous Mushrooms

“…The terpene synthase gene cluster was abundantly found in all mushroom genomes. This gene family corresponds to the largest group of secondary metabolite products in fungi 17 . The six mitogenomes ranged in size from 41,555 to 78,907 bp.…”

Chemical Constituents of the Mushroom Dictyophora indusiata and Their Anti-Inflammatory Activities

“…Only a relatively small number of higher fungal species have been chemically investigated; fungal natural products represent a vast and largely untapped source of potentially potent new pharmaceuticals [ 56 , 57 ]. Among fungal species, the basidiomycetes are one of the most important producers of diverse bioactive secondary metabolites [ 58 , 59 ]. Ganoderma lucidum and Poria cocos are two well-known medicinal basidiomycetes.…”