Biostimulation of Wound Healing in Vivo by a Helium-Neon Laser

Lyons, Robert W.; Abergel, R. Patrick; White, R.A.; Dwyer, Richard M.; Castel, J C; Uitto, Jouni

doi:10.1097/00000637-198701000-00011

Cited by 220 publications

(132 citation statements)

References 0 publications

Supporting

Mentioning

114

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have reported-beneficial effects of LLLT on chronic wound healing, in healthy and nonhealthy rats, as well as in some other small animals. 7,10,[19][20][21][22] Since blood flow is increased in the microcirculation during laser therapy, this could explain the enhancement of wound healing and reduced pain. 6,7 Others have suggested that LLLT is beneficial for wound healing in diabetics.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors have demonstrated that lowlevel laser therapy (LLLT) stimulates wound healing, by increasing collagen deposition and blood flow in the wound area. [6][7][8][9][10][11][12][13] Some lasers, when used with the proper parameters, affect fibroblasts and collagen production in vitro, and promising results have been found utilizing the HeNe laser (632.8 nm) with multiple exposures. 9,[14][15][16][17][18][19] One effect of laser therapy (5 J/cm 2 ) is increased local blood flow in normal human skin of the sole of the foot.…”

Section: Introduction Dmentioning

confidence: 99%

See 1 more Smart Citation

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

View full text Add to dashboard Cite

Objective: The aim of this work was to compare the effect of low-level laser therapy (LLLT) on the wound healing process in nondiabetic and diabetic rats. Background Data: Among the clinical symptoms caused by diabetes mellitus, a delay in wound healing is a potential risk for patients. It is suggested that LLLT can improve wound healing. Methods: The tissue used for this study was extracted from animals suffering from diabetes, which was induced by Streptozotocin ® , and from nondiabetic rats. Animals were assembled into two groups of 25 rats each (treated and control) and further subdivided into two groups: diabetic (n = 15) and nondiabetic (n = 10). A full-thickness skin wound was made on the dorsum area, with a round 8-mm holepunch. The treated group was irradiated by a HeNe laser at 632.8 nm, with the following parameters: 15 mW, exposition time of 17 sec, 0.025 cm 2 irradiated area, and energy density of 10 J/cm 2 . Square full-thickness skin samples (18 mm each side, including both injured and noninjured tissues) were obtained at 4, 7, and 15 days after surgery and analyzed by qualitative and quantitative histological methods. Results: Quantitative histopathological analysis confirmed the results of the qualitative analysis through histological microscope slides. When comparing tissue components (inflammatory cells, vessels and fibroblast/area), we found that treated animals had a less intense inflammatory process than controls. Conclusion: Results obtained by both qualitative and quantitative analyses suggested that irradiation of rats with HeNe (632.8 nm), at the tested dose, promoted efficient wound healing in both nondiabetic and diabetic rats as, compared to the control group. 474

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introduction Dmentioning

confidence: 99%

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

View full text Add to dashboard Cite

show abstract

“…Recently, some researchers concluded that some physical methods, including therapeutic ultrasound and laser treatments, accelerate and facilitate wound healing and increase scar quality [4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the effects of laser and ultrasound treatments on experimental wound healing in rats

Demir¹,

Yaray²,

Kırnap³

et al. 2004

JRRD

View full text Add to dashboard Cite

-A randomized controlled study investigated the effects of ultrasound and laser treatments on wound healing in rats. The duration of the inflammatory phase decreased with both laser and ultrasound treatments; however, laser was more effec-tive than ultrasound, with more significant results. The prolifera-tion phase showed, for both treatments, an increase in the level of hydroxyproline and the number of fibroblasts, as well as stimula-tion of the collagen synthesis and the composition. Laser treat-ment was again more effective than ultrasound. The wound breaking strength was significantly higher with both treatments, and no statistically significant difference emerged between the laser and ultrasound groups, although laser treatment provided a much greater increase in the wound breaking strength than ultra-sound. Both treatments have beneficial effects on the inflamma-tory, proliferation, and maturation phases of wound healing. Both can be used successfully for decubitis ulcers and chronic wounds, in conjunction with conventional therapies such as debridement and daily wound caring. However, laser treatment was more effective than ultrasound in the first two phases of wound healing.

show abstract

“…By the findings from previous studies, the effectiveness of LLLT on tissue repair was observed in various protocols [4][5][6][7][8][9]18 . So far, nonetheless, no work has validated the use of laser therapy when there is the presence of bacterial infection in the wound.…”

Section: Discussion Discussion Discussion Discussion Discussionmentioning

confidence: 99%

Effects of low intensity laser in in vitro bacterial culture and in vivo infected wounds

Pereira

Paula

Cielinski

et al. 2014

Rev. Col. Bras. Cir.

View full text Add to dashboard Cite

Results ResultsResults Results: in vitro: there was no statistically significant variation between the experimental groups as for the source plates and the derived ones (p>0.05). In vivo: there was a significant increase in the deposition of type I and III collagen in the wounds of the infected and irradiated animals when assessed on the fourth day of the experiment (p=0.034). Conclusion Conclusion Conclusion Conclusion Conclusion: lowintensity Laser Therapy applied with a wavelength of 904nm and dose 3J/cm 2 did not alter the in vitro growth of S. aureus in experimental groups; in vivo, however, it showed significant increase in the deposition of type I and III collagen in the wound of infected and irradiated animals on the fourth day of the experiment.

show abstract

Biostimulation of Wound Healing in Vivo by a Helium-Neon Laser

Cited by 220 publications

References 0 publications

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Comparison of the effects of laser and ultrasound treatments on experimental wound healing in rats

Effects of low intensity laser in in vitro bacterial culture and in vivo infected wounds

Contact Info

Product

Resources

About