Biosensors based on the thin-film magnetoresistive sensors

Kasatkin, S. I.; Vasil'eva, N. P.; Murav'ev, A. M.

doi:10.1134/s0005117910010121

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…Consequently, the detection of Dynabeads plays an important role in many biomedical applications. Various types of magnetic sensors have been used to detect MB, such as giant magnetoresistive sensors , superconducting quantum interference devices (SQUID) , spin‐valve sensors , anisotropic magnetoresistive (AMR) sensor , Hall sensors , resonant coil sensor , and a new type of magnetic sensor based on the giant magnetoimpedance (GMI) effect . The GMI effect is a classical electromagnetic phenomenon where the alternating current (AC) impedance of soft magnetic amorphous metals undergoes a large change when subjected to an external magnetic field .…”

Section: Introductionmentioning

confidence: 99%

A giant magnetoimpedance sensor for sensitive detection of streptavidin‐coupled Dynabeads

Wang

Yang

Lei

et al. 2014

Physica Status Solidi (a)

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An integrated giant magnetoimpedance (GMI) sensor has been used for the detection of Dynabeads® MyOne Streptavidin C1 (DMS). An Au film was sputtered onto magnetic sensing elements for the immobilization of DMS in order to develop an integrated biosensor for potentially biomedical applications. The GMI responses were measured for the detection of DMS from 0.1 µg mL−1 to 100 µg mL−1. We observed that the GMI effect was greatly improved at high frequencies owing to the presence of superparamagnetic beads. It was found that magnetic dipole fields had partly canceled each other out due to the uneven distributions and high‐density clusters of Dynabeads. High‐detection sensitivity was achieved in the detection of low concentrations of DMS. This integrated GMI sensor is well suited for detection of magnetic beads‐labeled biological components.

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Section: Introductionmentioning

confidence: 99%

A giant magnetoimpedance sensor for sensitive detection of streptavidin‐coupled Dynabeads

Wang

Yang

Lei

et al. 2014

Physica Status Solidi (a)

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“…But then again, AMR chips were not that sensitive enough to detect the magnetic moments of MNPs with core sizes in the order of a few nanometers. As the quest for linear sensitive AMR sensors progressed steadily over the years [115][116][117][118], a highly sensitive AMR sensor that could detect nanometer-sized MNP at the single molecular level was in high demand. In 2016, Hien et al [119] reported AMR-based genotyping by using a disposable card (SPA) and magnetically labeled DNA.…”

Section: Amr-based Sensors For Genotypingmentioning

confidence: 99%

Advances in Magnetoresistive Biosensors

Saha

et al. 2019

Micromachines

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Magnetoresistance (MR) based biosensors are considered promising candidates for the detection of magnetic nanoparticles (MNPs) as biomarkers and the biomagnetic fields. MR biosensors have been widely used in the detection of proteins, DNAs, as well as the mapping of cardiovascular and brain signals. In this review, we firstly introduce three different MR devices from the fundamental perspectives, followed by the fabrication and surface modification of the MR sensors. The sensitivity of the MR sensors can be improved by optimizing the sensing geometry, engineering the magnetic bioassays on the sensor surface, and integrating the sensors with magnetic flux concentrators and microfluidic channels. Different kinds of MR-based bioassays are also introduced. Subsequently, the research on MR biosensors for the detection of protein biomarkers and genotyping is reviewed. As a more recent application, brain mapping based on MR sensors is summarized in a separate section with the discussion of both the potential benefits and challenges in this new field. Finally, the integration of MR biosensors with flexible substrates is reviewed, with the emphasis on the fabrication techniques to obtain highly shapeable devices while maintaining comparable performance to their rigid counterparts.

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“…Struktur spin valve merupakan struktur yang diberi lapisan pengunci (pinning layer), sedangkan struktur multilayer adalah struktur dengan pengulangan lapisan ferromagnetik/nonmagnetik (FM/NM) dengan indeks n adalah jumlah pengulangan [5]. Lapisan tipis magnetik dikembangkan untuk sistem penyimpanan (hard-drive) dan pembacaan data digital [6] dengan harapan akan tercipta sensor-sensor dengan akurasi, kecepatan, dan Sensor GMR dapat digunakan dalam berbagai aplikasi, seperti sensor pengukuran arus, pengukuran jarak, pengukuran kecepatan rotasi, keberadaan (prensence), dan beberapa mulai merambah biosensor [7]. Penggunaan material GMR sebagai sensor magnet memiliki beberapa kelebihan dibandingkan sensor lainnya yakni, sensivitas yang tinggi, kestabilan temperatur yang tinggi, komsumsi daya rendah, ukuran kecil dan harga murah, sifat magnetik dapat bervariasi dalam rentang yang sangat luas [8].…”

Section: Pendahuluanunclassified

Kajian Magnetoresistansi pada Nanopartikel Magnetite (Fe3o4) yang Dienkapsulasi dengan Polyethylene Glycole (PEG) dan Biomaterial dengan Sensor Lapisan Tipis Co/Cu Multilayer Berbasis Giant Magnetoresistance (GMR) (Halaman 13 s.d. 19)

2015

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Abstrak -Telah dilakukan kajian magnetoresistansi (MR) pada nanopartikel magnetit (Fe 3 O 4 ) yang dienkapsulasi dengan poliethilen glikol (PEG)-4000 dan biomolekul menggunakan sensor lapisan tipis berbasis giant magnetoresistance (GMR). Lapisan tipis yang digunakan adalah Si/Cr(5nm)/ [Co(1,5nm)/Cu(x)] 20 /Cr(5nm) multilayer (x = 0,8; 0,9; dan 1,0 nm). Fenomena GMR dipengaruhi oleh variasi ketebalan lapisan tipis dan pelapisan nanopartikel Fe 3 O 4 yang dienkapsulasi dengan PEG dan penambahan biomolekul yang mengganggu mobilitas momen magnetik material. Resistansi pada ketebalan lapisan tipis Cu 0,8; 0,9; dan 1,0 nm ketika H=0 masing-masing 3,7; 3,5; dan 2,7 Ohm dan ketika H=599,7 G masing-masing 3,5; 3,2; dan 2,3 Ohm. Nilai MR ketika lapisan tipis dilapisi nanopartikel Fe 3 O 4 , Fe 3 O 4 yang dienkapsulasi dengan PEG, dan Fe 3 O 4 yang dienkapsulasi dengan PEG dan penambahan biomolekul masing-masing mengalami perubahan yang berbeda. Perubahan nilai MR pada lapisan tipis multilayer sebelum dan setelah pelapisan nanopartikel menunjukkan bahwa lapisan tipis Co/Cu multilayer dapat diaplikasikan sebagai sensor medan magnet dan potensial sebagai biosensor. (5nm) multilayer (x = 0,8; 0,9; dan 1,0 nm). GMR phenomenon that appears influenced by the thin film thickness variation and nanoparticle coatings which is encapsulated with PEG and addition of biomolecule that effected the mobility of magnetic moment. Resistances on the Cu layer with thickness of 0.8; 0.9 nm; and 1.0 nm when H=0 are 3.7; 3.5; and 2.7 Ohm, respectively, and when H=599.7 G are 3.5; 3.2; and 2.3 Ohm, respectively. The value of MR when a thin film coated by Fe 3 O 4 nanoparticles, Fe 3 O 4 encapsulated with PEG, and Fe 3 O 4 encapsulated with PEG and addition of biomolecule undergo different changes. The change of MR value in the thin film multilayer before and after being coated indicate that the thin film multilayer can be applied as a magnetic field sensor and it is potential as a biosensor. Abstract -A study of magnetoresistance has been done on magnetite nanoparticle (Fe 3 O 4 ) encapsulated with polyethylene glycole (PEG) and biomaterials using thin film sensor based on giant magnetoresistance (GMR). The thin film used is Si/Cr(5nm)/[Co(1.5nm)/Cu(x)] 20 /Cr

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Biosensors based on the thin-film magnetoresistive sensors

Cited by 10 publications

References 14 publications

A giant magnetoimpedance sensor for sensitive detection of streptavidin‐coupled Dynabeads

A giant magnetoimpedance sensor for sensitive detection of streptavidin‐coupled Dynabeads

Advances in Magnetoresistive Biosensors

Kajian Magnetoresistansi pada Nanopartikel Magnetite (Fe3o4) yang Dienkapsulasi dengan Polyethylene Glycole (PEG) dan Biomaterial dengan Sensor Lapisan Tipis Co/Cu Multilayer Berbasis Giant Magnetoresistance (GMR) (Halaman 13 s.d. 19)

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