Biosensor for heavy metals detection in wastewater: A review

Viswanathan, Karthik; Periyasamy, Selvakumar; Kumar, P. Senthil; Rangasamy, Gayathri; Pauline, J. Mercy Nisha; Ramaraju, Pradeep; Mohanasundaram, Sneka; Vo, Dai‐Viet N.

doi:10.1016/j.fct.2022.113307

Cited by 24 publications

(7 citation statements)

References 112 publications

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“…Biosensors can be classified as optical, thermal, piezoelectric, quartz crystal microbalance, or electrochemical depending on the type of transducer they utilize. Additionally, there are conductometric, amperometric, and potentiometric electrochemical biosensors [ 201 ].…”

Section: The Use Of Polymeric Micellar Systems To Develop (Bio)sensorsmentioning

confidence: 99%

“…The specific enzymes utilized as bioreceptors in enzyme biosensors can also be used to classify them (glucose biosensor, urea biosensor, cholesterol biosensor, etc.) [ 201 ]. DNA biosensors (DNA as a bioreceptor) and immunosensors are examples of further biosensors (antibody as bioreceptor) [ 205 ].…”

Section: The Use Of Polymeric Micellar Systems To Develop (Bio)sensorsmentioning

confidence: 99%

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: The Use Of Polymeric Micellar Systems To Develop (Bio)sensorsmentioning

confidence: 99%

Section: The Use Of Polymeric Micellar Systems To Develop (Bio)sensorsmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…Biosensors are instruments that use biological substances such as enzymes, DNA, antibodies, cells or microorganisms as bioreceptors, which recognize and capture the contaminant or analyte with high sensitivity and selectivity and trigger a physicochemical reaction (generation of light or heat, change in pH, and mass change) that can be transformed by the transducer into a detectable signal form. The three-dimensional structure and the active center of the enzymes are responsible for the recognition and high specificity for the analyte, which allow the union between enzyme and analyte through hydrogen bonds, electrostatic forces, or other non-covalent interactions, to trigger a reaction through a catalytic effect, which converts the analyte into another product that can be quantified or measurable for analysis [53]. The use of enzymes as bioreceptors has the advantages of short response times, real-time continuous detection signals, a low detection limit, low application costs with high specificity, sensitivity, and reliability [54,55].…”

Section: Enzymes Immobilization Applied As a Bioreceptor Element In B...mentioning

confidence: 99%

“…The indirect method is based on the inhibition of enzyme activity by the analyte. It is a very functional strategy for the detection of pesticides and heavy metals, since the metal ions react with the thiol group of the sulfhydryl group of the enzymatic structure, creating changes in the structure of the enzyme and affecting the catalytic activity, generating continuous changes that can be read as a signal [53,56].…”

Section: Enzymes Immobilization Applied As a Bioreceptor Element In B...mentioning

confidence: 99%

Immobilized Enzyme-based Novel Biosensing System for Recognition of Toxic Elements in the Aqueous Environment

et al. 2023

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Access to secure water sources has become one of the biggest challenges for human sustainability. Climate change and associated droughts make it difficult to guarantee the usual water source and move to groundwater use or to the re-use of treated wastewater remains unviable due the lack on the capacity of monitoring water quality. Moreover, reusing treated wastewater from repositories near anthropogenic sources represents a risk of high concentrations of emerging contaminants. The strategies involve a higher risk of encountering toxic elements with a heavy burden on human and environmental health. New accessible and reliable tools are required to detect any hazard from the waterbodies in real time to ensure safe management and also to decrease mismanagement or ilegal water discharges. One of the available options is to look into enzyme-based biosensors that can detect toxic elements in the water. The proposed biosensors require sensible elements to be accessible and durable for their proper function. The present revision shows in first place, the actual need of real time monitoring due the different sources and effects of emergent pollutants. Secondly, describes how enzymes can be immobilized for its application in biosensors and the rol enzymes play as bioreceptor element in biosensing. Thirdly, describes the transduction methods that can be observed, and finally the actual application of enzyme biosensors for the detection of different toxic elements. According to the presented literature enzyme-based biosensors have been successfully applied for the detection of a wide number of pollutants reaching detection limits comparable to traditional methods such as up to 0.018 nM of mercury. Furthermore, laccase seems to be the more applied enzyme in literature, but positive results are not limited to this enzyme and other candidates have been explored showing good detection rate.

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“…Heavy metal biosensors are used to achieve in situ detection and efficient bioremediation in contaminated environments ( Wei et al, 2014 ; Yin et al, 2016 ; Liu et al, 2022b ). Biosensors utilize biological components such as enzymes, antibodies, nucleic acids, or whole cells to selectively detect particular heavy metals and convert the biorecognition event into measurable signals (fluorescent, optical, or electrical signal) ( Velusamy et al, 2022 ). Among those biosensors, whole-cell biosensors can offer simplicity and low cost in in situ sensing, and also provide a chassis to embed remediation modules to eliminate heavy metals ( Velusamy et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Synthetic bacteria for the detection and bioremediation of heavy metals

Thai

Lim

2023

Front. Bioeng. Biotechnol.

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Toxic heavy metal accumulation is one of anthropogenic environmental pollutions, which poses risks to human health and ecological systems. Conventional heavy metal remediation approaches rely on expensive chemical and physical processes leading to the formation and release of other toxic waste products. Instead, microbial bioremediation has gained interest as a promising and cost-effective alternative to conventional methods, but the genetic complexity of microorganisms and the lack of appropriate genetic engineering technologies have impeded the development of bioremediating microorganisms. Recently, the emerging synthetic biology opened a new avenue for microbial bioremediation research and development by addressing the challenges and providing novel tools for constructing bacteria with enhanced capabilities: rapid detection and degradation of heavy metals while enhanced tolerance to toxic heavy metals. Moreover, synthetic biology also offers new technologies to meet biosafety regulations since genetically modified microorganisms may disrupt natural ecosystems. In this review, we introduce the use of microorganisms developed based on synthetic biology technologies for the detection and detoxification of heavy metals. Additionally, this review explores the technical strategies developed to overcome the biosafety requirements associated with the use of genetically modified microorganisms.

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Biosensor for heavy metals detection in wastewater: A review

Cited by 24 publications

References 112 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Immobilized Enzyme-based Novel Biosensing System for Recognition of Toxic Elements in the Aqueous Environment

Synthetic bacteria for the detection and bioremediation of heavy metals

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