Bioscaffolds embedded with regulatory modules for cell growth and tissue formation: A review

Wang, Pengju; Sun, Yazhou; Shi, Xiaoquan; Ning, Haohao; Liu, Haitao

doi:10.1016/j.bioactmat.2020.10.014

Cited by 23 publications

(17 citation statements)

References 169 publications

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“…[ 80 ] The ink composition and structure draw proper attention to using the suitable ink‐based biomaterial. [ 97 ] 3D bioprinting using cellulose materials has grown rapidly during the last years and reached desirable achievements. [ 98 ] Cellulose nanofibers and stem cells produce porous structures used in biomimetic tissue engineering which are characterized by interconnected, highly porous hydrophobic, or lipophilic scaffolds.…”

Section: Advanced Biomaterials Fabrication: 3d Bioprinting Based Cell...mentioning

confidence: 99%

Cellulose‐Based Biomaterials: Chemistry and Biomedical Applications

Hasanin

2022

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This review represents a fresh survey about cellulose‐based biomaterial for biomedical application, in which certain features that are essential to design potential biomedical materials. It illustrates their functionalizations, benefits, properties, and applications in the biomedical. Cellulose is produced from plants and alternative sources such as bacteria, algae, and fungi as well as animals where tunicate is the only animal source of cellulose. Biomedical materials based on cellulose attracts attention due to its unique physicochemical features and high biocompatibility. Thus, cellulose‐based biomaterials have wide potential to be used in large scale biomedical applications as a pioneering material that may be used alone or with other additives. Additionally, they are used in several biomedical applications such as drug delivery, wound dressing, and tissue engineering. However, cellulose is not extensively used in the biomedical industrial field, this may be due to the limitations of the full studies and the limitation of availability of clinical trials. Moreover, the biomaterials based on cellulose are a potential substrate for the 3D bioprinting field where the tissues and organs can be designed as prototype production. For all these reasons, this work will highlight the recent developments in the preparation methods of cellulose‐based biomaterials and their derivatives.

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Section: Advanced Biomaterials Fabrication: 3d Bioprinting Based Cell...mentioning

confidence: 99%

Cellulose‐Based Biomaterials: Chemistry and Biomedical Applications

Hasanin

2022

Starch Stärke

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“…The efficiency and regenerative potential of MN patches have been proved in terms of wound healing, neovascularization, and artificial organ reconstruction. 174 , 175 For instance, epicedial attachment of fibrin-coated MN patches harboring cardiac stromal cells promoted cardiac regeneration in a rat model of myocardial infarction. 176 It was suggested that this system can induce cardiac regeneration via the development of micro-sized channels that transfer the secretome of cardiac stromal cells into the ischemic sites.…”

Section: Microneedle Technologies In the Context Of Regenerative Medi...mentioning

confidence: 99%

Application of microneedle patches for drug delivery; doorstep to novel therapies

et al. 2022

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In the past decade, microneedle-based drug delivery systems showed promising approaches to become suitable and alternative for hypodermic injections and can control agent delivery without side effects compared to conventional approaches. Despite these advantages, the procedure of microfabrication is facing some difficulties. For instance, drug loading method, stability of drugs, and retention time are subjects of debate. Besides, the application of novel refining fabrication methods, types of materials, and instruments are other issues that need further attention. Herein, we tried to summarize recent achievements in controllable drug delivery systems (microneedle patches) in vitro and in vivo settings. In addition, we discussed the influence of delivered drugs on the cellular mechanism and immunization molecular signaling pathways through the intradermal delivery route. Understanding the putative efficiency of microneedle patches in human medicine can help us develop and design sophisticated therapeutic modalities.

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“…The term "tissue engineering" identifies tissue regeneration procedures of the human organism through the seeding of cells on structures (scaffolds) made up of specific materials and with peculiar characteristics, their cultivation in special reactors (bioreactors) until the colonization of the same scaffold, and to the neo-formation of a bioengineered tissue (Bettini et al, 2020;Cantore et al, 2018;Nosrati et al, 2020). The recent trend is the scaffolds creation for the in vitro genesis of bio-tissues (Wang et al, 2020); in this case, bioabsorbable polymeric materials used in 3D printers are employed, generally with fused deposition modeling (FDM) techniques (filament extrusion) or with bioprinting (nozzles that spray small amounts of liquid material). In studies on animal models, some authors have tested the isolation and use of D-dSCs and bio-scaffolds for bone regeneration, obtaining neo-formation of bone tissue in the grafted sites (Shoushrah et al, 2021).…”

Section: Current Perspectives In Regenerative Medicine Applicationsmentioning

confidence: 99%

“…To gather the rising demand for human tissues and organs since of diseases or accidents, scientific research is progressively more focusing on tissue engineering and regenerative medicine. The core common methods of set up tissues and organs are (I) the addition of bioscaffolds, growth factors, and MSCs into a culture medium for in vitro organization and (II) the implantation of bioscaffolds and growth factors for in vivo organization (Wang et al, 2020). Comparable to the natural extracellular matrix (ECM), topography, morphology and composition of scaffold manage cell behavior, showing influence on cell adhesion, proliferation, differentiation and migration.…”

Section: Introductionmentioning

confidence: 99%