Bioresponse-linked instrumental analysis

Bilitewski, Ursula; Brenner‐Weiß, Gerald; Hansen, Peter-Diedrich; Hock, Bertold; Meulenberg, Eline P.; Müller, G; Obst, U.; Sauerwein, H.; Scheller, Frieder W.; Schmid, Roland M.; Schnabl, G.; Spener, Friedrich

doi:10.1016/s0165-9936(00)00004-2

Cited by 20 publications

(10 citation statements)

References 14 publications

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“…However, the constantly increasing diversity of harmful substances and a range of potentially synergistic actions complicate a reliable assessment. Bioresponse-linked instrumental analytics bridges this gap to a certain extend as it links biomolecular recognition with chemical analysis [2]. Other approaches make use of the fact that harmful substances such as certain metals frequently accumulate in biological organisms.…”

Section: Biological Systems Respond Sensitively To External Cuesmentioning

confidence: 99%

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Rosenhahn

Sendra

2012

Biointerphases

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This review article summarizes some recent insights into the strategies used by marine organisms to select surfaces for colonization. While larger organisms rely on their sensory machinery to select surfaces, smaller microorganisms developed less complex but still effective ways to probe interfaces. Two examples, zoospores of algae and barnacle larvae, are discussed and both appear to have build-in test mechanisms to distinguish surfaces with different physicochemical properties. Some systematic studies on the influence of surface cues on exploration, settlement and adhesion are summarized. The intriguing notion that surface colonization resembles a parallelized surface sensing event is discussed towards its complementarity with conventional surface analytical tools. The strategy to populate only selected surfaces seems advantageous as waves, currents and storms constantly challenge adherent soft and hard fouling organism.

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Section: Biological Systems Respond Sensitively To External Cuesmentioning

confidence: 99%

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Rosenhahn

Sendra

2012

Biointerphases

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“…It has been presented under the term bioresponse-linked instrumental analysis [204] and is based on the concept that key processes of adverse effects of environmental contaminants can be determined at the molecular and subcellular level. Since often the first step in the sequence of events that may eventually lead to an adverse affects of chemicals on biota is binding to a receptor, affinity chromatography is a promising tool in EDA.…”

Section: Affinity Chromatographymentioning

confidence: 99%

Effect-Directed Analysis of Complex Environmental Contamination

Brack¹

2011

The Handbook of Environmental Chemistry

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“…On the other hand, biological assays are unable to identify the chemical structures of these contaminants. A possible solution is seen in a skilful combination of a biological selection and chemical analysis, which is defined as bioresponse-linked instrumental analysis (BLIA) [2]. BLIA combines two processes, biomolecular recognition for selection of bioactive substances and chemical analysis, i.e.…”

Section: Introductionmentioning

confidence: 99%

“…Biomolecular recognition components which can be exploited for bioresponse-linked instrumental analysis[2] …”

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confidence: 99%

Approaches to bioresponse-linked instrumental analysis in water analysis

Brenner‐Weiß¹,

Obst²

2003

Analytical and Bioanalytical Chemistry

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A new concept based on hyphenation of biotests, for biological selection, and chemical analysis is introduced for water analysis. Biomolecular recognition components such as receptors, enzymes, and nucleic acids integrated in biological reaction chains are used for binding and selective enrichment of known and unknown biologically active substances in water samples; this is followed by identification and quantitation. The coupling of biomolecular recognition and binding to chemical analysis can be achieved either in discrete analytical steps, e.g. binding and elution of bioactive ligands from affinity columns followed by chemical analysis, or by methods capable of monitoring the binding of the ligand and simultaneous verification of its identity. This analytical strategy, denoted bioresponse-linked instrumental analysis (BLIA), enables detection of potential biological effects and identification of the analyte causing these effects. Several examples are presented.

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Bioresponse-linked instrumental analysis

Cited by 20 publications

References 14 publications

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Surface Sensing and Settlement Strategies of Marine Biofouling Organisms

Effect-Directed Analysis of Complex Environmental Contamination

Approaches to bioresponse-linked instrumental analysis in water analysis

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