Bioresorbierbare Knochenklebstoffe

Abstract

Bone adhesives are degraded to non-toxic products and resorbed after fulfilling their function in contact with living tissue. There has been a growing interest in the use of such adhesives in all fields of medicine in recent years. The wish of trauma surgeons and orthopaedic for alternatives to osteosynthesis is reflected in the development of a variety of surrogates of biological or synthetic origin. Despite a longstanding history of research in this field, a clinically applicable alternative in the field of bone gluing has not yet been found. This application has consistently failed because these adhesives were not tailored to the conditions met within the living organism. The following article is meant to provide an overview of the development, the state of the art, and today's knowledge of bone adhesives. In addition, it points out the tremendous progress in this area, made possible by the joint efforts of basic researchers and surgeons. The results of this collaboration show that in the future a successful reconstructive surgery using synthetic biomaterials will become feasible.

In vitro and in vivo studies on the use of Histoacryl® as a soft tissue glue

“…But in contrast to Wbrin glue, they usually have insuYcient haemostatic eVects. In addition to the allergy risks caused by the natural chemical component in these semi-synthetic glues, they contain toxic compounds (formaldehyde or glutaraldehyde) which limit the biocompatibility [1,[4][5][6].…”

“…They are easy to use, quickly and completely absorbable as well as non-toxic. Their disadvantage is a low adhesive strength and therefore, they cannot be used in stress-bearing implant beds [1][2][3].…”

Biomimetic Adhesive Materials Containing Cyanoacryl Group for Medical Application

“…Recently, new generations of bioadhesives have been considered for bone fixation, thus anatomically fixating small fragments and avoiding further surgical operations to remove the mechanical devices [1,2,3,4,5,6]. Nevertheless, although many challenges have been undertaken, still no bone adhesives are suitable for practical use in clinical practice [7]. An appreciable model for underwater adhesion is the mussel protein, which is well known for its competence to stick to wet surfaces [2,6,7,8,9,10,11,12].…”

Animal study for the development and validation of new tissue adhesives for the use in otorhinolaryngology

“…But in contrast to fibrin glue, they usually have insufficient haemostatic effects. In addition to the allergy risks caused by the natural chemical component in these semi-synthetic glues, they contain toxic compounds (formaldehyde or glutaraldehyde) which limit the biocompatibility [1,[4][5][6].…”

“…They are easy to use, quickly and completely absorbable as well as non-toxic. Their disadvantage is a low adhesive strength and therefore they can not be used in stress-bearing implant beds [1][2][3].…”