Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Shin, Jiho; Yan, Yan; Bai, Wubin; Xue, Yeguang; Gamble, Paul; Tian, Limei; Kandela, Irawati; Haney, Chad R.; Spees, William M.; Lee, Yechan; Choi, Minseok; Ko, Jonathan; Ryu, Hangyu; Chang, Jan Kai; Pezhouh, Maryam Kherad; Kang, Seung Kyun; Won, Sang Min; Yu, Ki Jun; Zhao, Jianing; Lee, Yoon Kyeung; MacEwan, Matthew R.; Song, Sheng; Huang, Yonggang; Ray, Wilson Z.; Rogers, John A.

doi:10.1038/s41551-018-0300-4

Cited by 200 publications

(162 citation statements)

References 33 publications

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“…The limitations arise mainly from the inability of bioresorbable encapsulation layers, including polymers such as silk fibroin ( 22 ) and poly(lactic- co -glycolic acid) (PLGA) ( 20 ) and inorganic layers such as silicon dioxide ( 26 , 27 ) and various metal oxides ( 28 ) formed by chemical or physical vapor deposition, to prevent permeation of water into the active regions of the devices for extended periods. Recent work demonstrates that ultrathin layers of silicon dioxide thermally grown on device-grade silicon wafers (t-SiO 2 ) can be used as bioresorbable encapsulation layers, to enable stable operation of intracranial pressure (ICP) and temperature (ICT) sensors over a period of 25 days in rats ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

et al. 2019

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Continuous measurements of pressure and temperature within the intracranial, intraocular, and intravascular spaces provide essential diagnostic information for the treatment of traumatic brain injury, glaucoma, and cardiovascular diseases, respectively. Optical sensors are attractive because of their inherent compatibility with magnetic resonance imaging (MRI). Existing implantable optical components use permanent, nonresorbable materials that must be surgically extracted after use. Bioresorbable alternatives, introduced here, bypass this requirement, thereby eliminating the costs and risks of surgeries. Here, millimeter-scale bioresorbable Fabry-Perot interferometers and two dimensional photonic crystal structures enable precise, continuous measurements of pressure and temperature. Combined mechanical and optical simulations reveal the fundamental sensing mechanisms. In vitro studies and histopathological evaluations quantify the measurement accuracies, operational lifetimes, and biocompatibility of these systems. In vivo demonstrations establish clinically relevant performance attributes. The materials, device designs, and fabrication approaches outlined here establish broad foundational capabilities for diverse classes of bioresorbable optical sensors.

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Section: Introductionmentioning

confidence: 99%

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

et al. 2019

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“… 14 , 49 , 60 Water penetration into the device is a common denominator for all of these breakdown mechanisms, for why separate water barrier layers have been studied to improve the stability of bioresorbable sensors. 61 , 62 There is a great demand for encapsulation layers that could be applied onto bioresorbable polymer substrates because the deposition of inorganic coatings often requires elevated temperatures. In this section, the pros and cons of low-temperature atomic layer deposited (ALD) TiO 2 films on polymeric substrates are discussed.…”

Section: Resultsmentioning

confidence: 99%

“…Inorganic coatings on rigid nondegradable wafers have been previously discussed in the literature. 61 , 62 , 70 …”

Section: Resultsmentioning

confidence: 99%

Materials and Orthopedic Applications for Bioresorbable Inductively Coupled Resonance Sensors

Palmroth

Salpavaara

Vuoristo

et al. 2020

ACS Appl. Mater. Interfaces

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Bioresorbable passive resonance sensors based on inductor–capacitor (LC) circuits provide an auspicious sensing technology for temporary battery-free implant applications due to their simplicity, wireless readout, and the ability to be eventually metabolized by the body. In this study, the fabrication and performance of various LC circuit-based sensors are investigated to provide a comprehensive view on different material options and fabrication methods. The study is divided into sections that address different sensor constituents, including bioresorbable polymer and bioactive glass substrates, dissolvable metallic conductors, and atomic layer deposited (ALD) water barrier films on polymeric substrates. The manufactured devices included a polymer-based pressure sensor that remained pressure responsive for 10 days in aqueous conditions, the first wirelessly readable bioactive glass-based resonance sensor for monitoring the complex permittivity of its surroundings, and a solenoidal coil-based compression sensor built onto a polymeric bone fixation screw. The findings together with the envisioned orthopedic applications provide a reference point for future studies related to bioresorbable passive resonance sensors.

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“…The normal stress distribution simulation results of the encapsulated sensor are shown in Figure 2 d. When subjected to a uniform load of 0.12 MPa, which is the top bound of a human normal blood pressure of 140 mmHg, 5 the stress quantity and distribution of the encapsulated sensor was almost the same as that of the unencapsulated pressure sensor; thus, the microlayer parylene coating was loaded very slightly (showing blue in Figure 2 d) and not appreciably influencing the sensitivity of the sensor. The stress concentration points in the square silicon component in the encapsulated pressure sensor chip still appear in the middle points of its four edges above the cavity of the silicon cup.…”

Section: Resultsmentioning

confidence: 99%

Ultrathin and Robust Micro–Nano Composite Coating for Implantable Pressure Sensor Encapsulation

et al. 2020

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Implantable pressure sensors enable more accurate disease diagnosis and real-time monitoring. Their widescale usage is dependent on a reliable encapsulation to protect them from corrosion of body fluids, yet not increasing their sizes or impairing their sensing functions during their lifespans. To realize the above requirements, an ultrathin, flexible, waterproof while robust micro–nano composite coating for encapsulation of an implantable pressure sensor is designed. The composite coating is composed of a nanolayer of silane-coupled molecules and a microlayer of parylene polymers. The mechanism and principle of the composite encapsulation coating with high adhesion are elucidated. Experimental results show that the error of the sensors after encapsulation is less than 2 mmHg, after working continuously for equivalently over 434 days in a simulated body fluid environment. The effects of the coating thickness on the waterproof time and the error of the sensor are also studied. The encapsulated sensor is implanted in an isolated porcine eye and a living rabbit eye, exhibiting excellent performances. Therefore, the micro–nano composite encapsulation coating would have an appealing application in micro–nano-device protections, especially for implantable biomedical devices.

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Bioresorbable pressure sensors protected with thermally grown silicon dioxide for the monitoring of chronic diseases and healing processes

Cited by 200 publications

References 33 publications

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Materials and Orthopedic Applications for Bioresorbable Inductively Coupled Resonance Sensors

Ultrathin and Robust Micro–Nano Composite Coating for Implantable Pressure Sensor Encapsulation

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