Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Shin, Jiho; Liu, Zhonghe; Bai, Wubin; Liu, Yonghao; Yan, Yan; Xue, Yeguang; Kandela, Irawati; Pezhouh, Maryam Kherad; MacEwan, Matthew R.; Huang, Yonggang; Ray, Wilson Z.; Zhou, Weidong; Rogers, John A.

doi:10.1126/sciadv.aaw1899

Cited by 161 publications

(181 citation statements)

References 47 publications

(59 reference statements)

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“…Other potential trends are the application of new technologies like 3D printing of magnesium implants (Nickels, 2019), the use of computational tools to design and analyze implants (Riaz, Shabib, & Haider, 2019), and the development of medical devices for real-time health monitoring via biodegradable sensors (Chatterjee, Saxena, Padmanabhan, Jayachandra, & Pandya, 2019). The measurement of parameters such as, for example, temperature or pressure in organs and vessels could be used to monitor the progression of traumatic or chronic diseases and the health process of the patient (Shin et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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Section: Resultsmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Section: Bioresorbable Optical Devicesmentioning

confidence: 99%

“…Right: In vivo calibration of the pressure sensor, against commercial sensor measurements. Reproduced under the terms of the CC BY license . Copyright 2019, The Authors, Published by American Association for the Advancement of Science.…”

Section: Bioresorbable Optical Devicesmentioning

confidence: 99%

“…In 2019, Shin et al reported on bioresorbable optical sensors based on resonant effects, for instance, a Fabry–Pérot interferometer (FPI) and a photonic crystal cavity, for in vivo pressure and temperature measurements (Figure b). Concerning the FPI, starting with SOI wafers, an air cavity was realized as a square through‐hole (250 × 250 µm size) in a Si slab (10 µm thick), which was sandwiched between two Si NM (250 nm thick) diaphragms, using amorphous silica (200 nm thick, obtained from PDMS calcination) as an adhesion layer; thermal SiO 2 (10 nm thick) was used as encapsulation layer.…”

Section: Bioresorbable Optical Devicesmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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“…Here, bioresorbable constituent materials minimize inflammatory responses and eliminate the need for secondary surgical extraction. [ 9–13 ] Recent examples include not only pressure but also temperature sensors for the intracranial space; [ 14–16 ] photonic devices for monitoring physiological status and neural activity; [ 17 ] wireless electronic systems for neuroregenerative therapy; [ 18 ] platforms for spatiotemporal mapping of electrical activity from the cerebral cortex; [ 19 ] drug release vehicles for infection abatement; [ 20 ] and systems for measuring blood flow. [ 21 ] Realizing consistent performance throughout a clinically relevant monitoring period with devices that bioresorb completely over slightly longer timescales represents an important goal.…”

Section: Introductionmentioning

confidence: 99%

Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

Yang

Lee

Xue

et al. 2020

Adv Funct Materials

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Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes of bioresorption offer advantages in this context, by eliminating the costs and risks associated with retrieval. A class of bioresorbable pressure sensor that is capable of operational lifetimes as long as several weeks and physical lifetimes as short as several months, as combined metrics that represent improvements over recently reported alternatives, is presented. Key advances include the use of 1) membranes of monocrystalline silicon and blends of natural wax materials to encapsulate the devices across their top surfaces and perimeter edge regions, respectively, 2) mechanical architectures to yield stable operation as the encapsulation materials dissolve and disappear, and 3) additional sensors to detect the onset of penetration of biofluids into the active sensing areas. Studies that involve monitoring of intracranial pressures in rat models over periods of up to 3 weeks demonstrate levels of performance that match those of nonresorbable clinical standards. Many of the concepts reported here have broad applicability to other classes of bioresorbable technologies.

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Bioresorbable optical sensor systems for monitoring of intracranial pressure and temperature

Cited by 161 publications

References 47 publications

Development of magnesium implants by application of conjoint‐based quality function deployment

Development of magnesium implants by application of conjoint‐based quality function deployment

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Materials, Mechanics Designs, and Bioresorbable Multisensor Platforms for Pressure Monitoring in the Intracranial Space

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