Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats

Lewandrowski, Kai‐Uwe; Gresser, Joseph D.; Wise, Donald L.; Trantolo, Debra J.

doi:10.1016/s0142-9612(99)00179-9

Cited by 142 publications

(94 citation statements)

References 23 publications

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“…Bone is the most transplanted tissue. More than 2.2 million bone grafts are used world-wide every year (15). Autogenous bone graft is noteworthy as being the most frequently selected graft for these procedures (5).…”

Section: Resultsmentioning

confidence: 99%

“…Before this research synthetic materials were seldom preferred over autografts and allografts. The use of synthetic grafts was limited to a level of 10% of all grafts world-wide (15). The reasons for this limited use were unpredictable resorption periods, diffi culty in shaping, foreign body reaction and insuffi cient clinical and experimental studies.…”

Section: Resultsmentioning

confidence: 99%

“…The aim behind the use of these materials is the provision of a matrix formation that permits bone growth into the implant (15).…”

Section: Introductionmentioning

confidence: 99%

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An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Atılgan¹,

Yaman²,

Yilmaz³

et al. 2007

Biotechnology & Biotechnological Equipment

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Atılgan¹,

Yaman²,

Yilmaz³

et al. 2007

Biotechnology & Biotechnological Equipment

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“…1 Mineralized implants such as hydroxyapatite cubes can turn into live bone in dental or orthopedic settings, however, sometimes the graft is resorbed or fails to connect to the host tissue with no foreseeable reason. 2,3 One explanation can be that colonization of the graft by stem cells is too slow and falls below the threshold for bone remodeling. [4][5][6] The ideal bone graft can be characterized by good mechanical strength, osteoinductive, osteoconductive, and osteogenic capabilities and only the autologous human bone graft possesses all of the mentioned properties.…”

mentioning

confidence: 99%

Freeze‐dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts

Weszl

Skaliczki

Cselenyák

et al. 2011

Journal Orthopaedic Research

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Mineralized scaffolds are widely used as bone grafts with the assumption that bone marrow derived cells colonize and remodel them. This process is slow and often unreliable so we aimed to improve the biocompatibility of bone grafts by pre-seeding them with human mesenchymal stem cells from either bone marrow or dental pulp. Under standard cell culture conditions very low number of seeded cells remained on the surface of freeze-dried human or bovine bone graft or hydroxyapatite. Coating the scaffolds with fibronectin or collagen improved seeding efficiency but the cells failed to grow on the surface until the 18th day. In contrast, human albumin was a very potent facilitator of both seeding and proliferation on allografts which was further improved by culturing in a rotating bioreactor. Electron microscopy revealed that cells do not form a monolayer but span the pores, emphasizing the importance of pore size and microstructure. Albumin coated bone chips were able to unite a rat femoral segmental defect, while uncoated ones did not. Micro-hardness measurements confirmed that albumin coating does not influence the physical characteristics of the scaffold, so it is possible to introduce albumin coating into the manufacturing process of lyophilized bone allografts. ß

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“…Specific surgical techniques such as distraction osteogenesis, implantation of biomaterials (bone substitutes) and implants of bone grafting have been developed to reach bone regeneration [1,2]. Demand for bone grafts is considerable and represents the second most common procedure after blood transplants, with more than 2.2 million bone grafts performed annually worldwide in orthopedics and dentistry [3].…”

Section: Introductionmentioning

confidence: 99%

Regenerative Medicine: A New Paradigm in Bone Regeneration

Chaparro¹,

Linero²

2016

Advanced Techniques in Bone Regeneration

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Bone defects are the cause of functional disability and the restoration of skeletal function remains an important challenge on orthopedics, neurosurgery and oral and maxillofacial surgery. Because of the limitations of the currently used techniques for the reconstruction of bone defects and the difficulties for the implementation of new therapeutic strategies, a new paradigm in the field of reconstructive surgery has arisen, leading to tissue engineering and regenerative medicine. Mesenchymal stem cells (MSC) have emerged as a promising alternative for the treatment of bone lesions. It was postulated that the therapeutic action was the result of proliferation and differentiation of MSCs, replacing injured tissue. However, recent studies have shown that MSCs secrete a number of trophic factors that have a strong effect during repair and tissue regeneration. This represents a shift from a paradigm centered on MSC proliferation and differentiation to a new paradigm in which the MSCs exert their beneficial effect by the secretion of paracrine factors that induce endogenous repair mechanisms. This chapter will bring together basic and clinical aspects, focused on novel findings on MSC paracrine effect and the development of new therapeutic strategies based on growth factors, cytokines and signaling molecules involved in bone regeneration.

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Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats

Cited by 142 publications

References 23 publications

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

An Experimental Comparison of the Effects of Calcium Sulfate Particles and β-Tricalcium Phosphate/Hydroxyapatite Granules on Osteogenesis in Internal Bone Cavities

Freeze‐dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts

Regenerative Medicine: A New Paradigm in Bone Regeneration

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