Bioreducible micelles and hydrogels with tunable properties from multi-armed biodegradable copolymers

Sun, Lin; Liu, Wei; Dong, Chang‐Ming

doi:10.1039/c1cc14663g

Cited by 50 publications

(64 citation statements)

References 25 publications

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“…However, the lack of biodegradability of these thermosensitive polymers greatly limited their clinical trials. To improve this limitation, biodegradable and biocompatible copolymers such as poly(lactic acid)‐ b ‐PEO and poly(ε‐caprolactone)‐ b ‐PEO have been widely investigated for various nanomedicine and injectable hydrogels, while the LCSTs of these copolymers are higher than the human body temperature 7–18. Thus, discovering thermosensitive biodegradable polymers with tunable LCST is very important for polymeric nanomedicine and injectable tissue engineering 10, 11…”

Section: Introductionmentioning

confidence: 99%

Synthesis, conformation transition, liquid crystal phase, and self‐assembled morphology of thermosensitive homopolypeptide

Liao

Dong

2012

J. Polym. Sci. A Polym. Chem.

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Thermosensitive diethylene glycol‐derived poly(L‐glutamate) homopolypeptides (i.e., poly‐L‐EG2‐Glu) with different molecular weights (MW) (Mn,GPC = 5380–32520) were synthesized via the ring‐opening polymerization (ROP) of EG2‐L‐glutamate N‐carboxyanhydride (EG2‐Glu‐NCA) in N,N‐dimethylformamide solution at 50 °C. Their molecular structure, conformation transition, liquid crystal (LC) phase behavior, lower critical solution temperature (LCST) transition, and morphology evolution were thoroughly characterized by means of FTIR, 1H NMR, gel permeation chromatography, differential scanning calorimetry, wide angle X‐ray diffraction, polarized optical microscope, transmission electron microscope, and dynamic light scattering. In solid state, the homopolypeptide poly‐L‐EG2‐Glu presented a conformation transition from α‐helix to β‐sheet with increasing their MW at room temperature, while it mainly assumed an α‐helix of 80–86% in aqueous solution. Poly‐L‐EG2‐Glu showed a thermotropic LC phase with a transition temperature of about 100 °C in solid state, while it gave a reversible LCST transition of 34–36 °C in aqueous solution. The amphiphilic homopolypeptide poly‐L‐EG2‐Glu self‐assembled into nanostructures in aqueous solution, and their critical aggregation concentrations decreased with increasing MW. Interestingly, their morphology changed from spherical micelles to worm‐like micelles, then to fiber micelles with increasing MW. This work provides a simple method for the generation of different nanostructures from a thermosensitive biodegradable homopolypeptide. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

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Section: Introductionmentioning

confidence: 99%

Synthesis, conformation transition, liquid crystal phase, and self‐assembled morphology of thermosensitive homopolypeptide

Liao

Dong

2012

J. Polym. Sci. A Polym. Chem.

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“…After treatment with DTT, GPC curves revealed no signal compared with PSS (Figure b), suggesting that polymer main chain had been completely degraded. This total degradation inspired us to design drug/gene vehicles in the future to avoid the toxicity induced by the bigger aggregates of hydrophobic segment for mono‐cleavable disulfide‐containing polymers …”

Section: Methodsmentioning

confidence: 99%

A Versatile Strategy to Main Chain Sulfur/Selenium‐Functionalized Polycarbonates by Macro‐Ring Closure of Diols and Subsequent Ring‐Opening Polymerization

Wei

Zhang

Yan

et al. 2017

Chemistry A European J

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Herein, a new class of main chain functionalized aliphatic polycarbonates with sulfur/selenium functional groups on the backbone is reported. Sulfur/selenium-containing cyclic carbonate monomers (M ) are designed and synthesized by enzyme-catalyzed intermolecular macro-ring closure of related diols. The proposed synthetic strategy is tolerant of other functionalities such as N-substituted groups. The ring opening polymerization (ROP) of M occurs readily as a versatile route to generate a new family of main chain sulfur/selenium substituted aliphatic polycarbonates (PR) with predictable molecular weights (MW), narrow molecular-weight distribution and controlled copolymer composition. The resultant polymers can be oxidized and/or reduced by treatment with hydrogen peroxide (H O ) or dithiothreitol (DTT), highlighting their potential for applications in the stimuli-responsive field and inflammation/cancer targeting. With these desirable results, it is revealed that this versatile technique can provide a broad-reaching method to the next generation of innovative materials, especially, well-defined biodegradable chalcogen-based main chain functional biomaterials.

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“…[30] The drug-released solution was extracted 5ml periodically (2, 6, 12, 24, 48 h…) and replaced with an equal volume of fresh medium. The amount of DOX released from nanoparticles and hydrogel was recorded by UV-vis at 500 nm at room temperature.…”

Section: In Vitro Release Of Dox Loaded Nanoparticles and Hydrogelsmentioning

confidence: 99%

Rational design of shear-thinning supramolecular hydrogels with porphyrin for controlled chemotherapeutics release and photodynamic therapy

Jin

Dai

et al. 2015

European Polymer Journal

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Bioreducible micelles and hydrogels with tunable properties from multi-armed biodegradable copolymers

Cited by 50 publications

References 25 publications

Synthesis, conformation transition, liquid crystal phase, and self‐assembled morphology of thermosensitive homopolypeptide

Synthesis, conformation transition, liquid crystal phase, and self‐assembled morphology of thermosensitive homopolypeptide

A Versatile Strategy to Main Chain Sulfur/Selenium‐Functionalized Polycarbonates by Macro‐Ring Closure of Diols and Subsequent Ring‐Opening Polymerization

Rational design of shear-thinning supramolecular hydrogels with porphyrin for controlled chemotherapeutics release and photodynamic therapy

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