Bioreactors Based on Monolith‐Supported Ionic Liquid Phase for Enzyme Catalysis in Supercritical Carbon Dioxide

Lozano, Pedro; García‐Verdugo, Eduardo; Piamtongkam, Rungtiwa; Karbass, Naima; Diego, Teresa De; Burguete, M. Isabel; Luis, Santiago V.; Iborra, José L.

doi:10.1002/adsc.200600554

Cited by 129 publications

(89 citation statements)

References 66 publications

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“…[21,23] Polymers 2a, 3a and 7b, c were expected to play different roles in the reaction medium. Polymers 2a and 3a were used as the supports for the Pd catalytic species (4a and 5a), [23] while 7b, c were expected to serve as the supported base needed to neutralize the acid formed during the course of the reaction, leading to salt-free products.…”

Section: Resultsmentioning

confidence: 99%

“…[21] Recently we have demonstrated that the nature and loading of the ionic liquid-like units in the polymer influence some important macroscopic properties of the material, [22] and play an important role in the catalytic activity of the system, controlling the release of the active species and allowing their efficient recapture after the reaction. [23] Furthermore, SILLPs with basic character proved to be efficient catalysts for the Henry reaction in batch and in continuous-flow modes.…”

Section: Introductionmentioning

confidence: 99%

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Polymer Cocktail: A Multitask Supported Ionic Liquid‐Like Species to Facilitate Multiple and Consecutive CC Coupling Reactions

et al. 2010

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Polymer-supported ionic liquid-like species (SILLPs) with different functionalities have been combined to obtain new catalytic systems (polymer cocktail) with improved properties towards their application for C À C coupling reactions. The SILLPs have been synthesized in a simple way and combined to play different functions in the reaction medium. Those roles involve simultaneously (or consecutively) their actuation as supported reagents, precatalysts and scavengers of undesired reaction side-products. The system has been tested by employing three different C À C coupling reactions for 8 consecutive cycles. Moreover, different aryl bromides and iodides have proved to be efficiently transformed by the catalytic cocktail. Finally, the Heck reaction has been conducted in continuous-flow conditions using a packed bed of this polymer cocktail and employing supercritical carbon dioxide (scCO 2 ) as a solvent, which cannot be carried out with the use of soluble bases as this would lead to the clogging of the reactor. Finally, the SILLPs cocktail enables one to combine different reaction steps and purification in a single vessel, which represents a significant improvement in terms of process intensification and green chemistry. This is particularly true in the case of the use of scCO 2 as this allows the direct production of crude materials not contaminated either by salts or by solvents.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Polymer Cocktail: A Multitask Supported Ionic Liquid‐Like Species to Facilitate Multiple and Consecutive CC Coupling Reactions

et al. 2010

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“…Table 1 summarizes some of the results found [40]. It can be seen that for all the immobilized derivatives, the productivity in the synthetic process was increased with temperature, reaching the maximum level at 80°C, and then decreasing for 100 °C.…”

Section: Catalytic Systems Based On M-sillpsmentioning

confidence: 77%

Development of efficient processes under flow conditions based on catalysts immobilized onto monolithic supported ionic liquid-like phases

Burguete

García‐Verdugo

Karbass

et al. 2009

Pure and Applied Chemistry

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The introduction of imidazolium subunits into polystyrene-divinylbenzene (PS-DVB) polymers enables the preparation of a variety of catalytic systems. Those include the stabilization of catalytically active Pd nanoparticles (PdNPs), immobilized enzymes, and basic catalysts. The use of monolithic supports having the appropriate morphological properties is greatly advantageous for the development of efficient catalytic processes under flow conditions based on those systems. On the other hand, the combination of those supported catalytic systems and flow conditions can be further implemented, in terms of green chemistry, by the substitution of the use of traditional solvents by environmentally friendly conditions such as the use of supercritical fluids (SCFs).

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“…These are prepared as monoliths based on PDS coated with imidazolium [77]. The monoliths were able to absorb lipase B from C. antarctica.…”

Section: Pds Coated With Ionic Liquidsmentioning

confidence: 99%

Immobilization of Proteins in Poly-Styrene-Divinylbenzene Matrices: Functional Properties and Applications

Rafael¹,

Hernández²,

Barbosa³

et al. 2015

COC

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Supports based on poly-styrene-divinylbenzene (PSD) are commercially available since a long time ago. However, they are not commonly used as enzyme immobilization matrices. The main reason for this lies in the negative effect of the very hydrophobic surface on enzyme stability that produces the instantaneous enzyme inactivation in many instances. However, they have recently regained some impact on enzyme immobilization. They are easy to modify, and have been prepared with different modifiers. We will pay special attention to the coating of these supports with ionic liquids, which permits to have the ionic liquid phase anchored to the solid and modulate the enzyme properties without risk of losing these expensive and potentially toxic compounds. Thus, this review will present the covalent or physical immobilization of enzymes on PSD supports, submitted to different modifications. Moreover, lipases immobilized via interfacial activation on some naked PSD supports have shown some unexpected improvement in their catalytic properties, with uses in reactions like hydrolysis, esterification or transesterification.

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Bioreactors Based on Monolith‐Supported Ionic Liquid Phase for Enzyme Catalysis in Supercritical Carbon Dioxide

Cited by 129 publications

References 66 publications

Polymer Cocktail: A Multitask Supported Ionic Liquid‐Like Species to Facilitate Multiple and Consecutive CC Coupling Reactions

Polymer Cocktail: A Multitask Supported Ionic Liquid‐Like Species to Facilitate Multiple and Consecutive CC Coupling Reactions

Development of efficient processes under flow conditions based on catalysts immobilized onto monolithic supported ionic liquid-like phases

Immobilization of Proteins in Poly-Styrene-Divinylbenzene Matrices: Functional Properties and Applications

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