Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds

Indraningrat, Anak Agung Gede; Smidt, Hauke; Sipkema, Detmer

doi:10.3390/md14050087

Cited by 158 publications

(142 citation statements)

References 185 publications

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“…The genus Pseudovibrio is known as the second most prolific bacterial genus that has been isolated from sponges and produces antimicrobial activities. This genus produces the antibacterial compound tropodithietic acid [29]. Pseudomonas sp.…”

Section: Discussionmentioning

confidence: 99%

“…Examples of these important polyketides include swinholide from the sponge Theonella swinhoei [27,28] and mayamycin produced by Streptomyces sp. HB202 from the sponge Haliclona simulans and H. panicea [29,30] that have potent antibiotic activities. Halichondrin B isolated from the sponge Halichondria okadai also displays potent anticancer activity [31,32].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diversity and Bioactivity of Marine Bacteria Associated with the Sponges Candidaspongia flabellata and Rhopaloeides odorabile from the Great Barrier Reef in Australia

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diversity and Bioactivity of Marine Bacteria Associated with the Sponges Candidaspongia flabellata and Rhopaloeides odorabile from the Great Barrier Reef in Australia

et al. 2017

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“…For example, we draw readers to the recent excellent review by Zhang et al which describes in detail over 107 cytotoxic agents which have been discovered from 1955 to 2016 that are metabolized by marine sponge-derived symbionts alone [95] (including terpenes, alkaloids, peptides, aromatics, lactones, and steroids, amongst others). Several other recent detailed reviews are also available which provide information on the many compounds discovered from marine invertebrates, including cytotoxic, anti-microbial, anti-protozoal, anti-leishmanial, anti-trypanosomal and anti-inflammatory compounds, compounds which may actually originate from the host-associated microbes and not the invertebrates themselves [8,19,20,48,[97][98][99][100][101][102][103][104][105][106].…”

Section: Constraints and Future Prospectsmentioning

confidence: 99%

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

et al. 2017

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Abstract:Invertebrates account for more than 89% of all extant organisms in the marine environment, represented by over 174,600 species (recorded to date). Such diversity is mirrored in (or more likely increased by) the microbial symbionts associated with this group and in the marine natural products (or MNPs) that they produce. Since the early 1950s over 20,000 MNPs have been discovered, including compounds produced by symbiotic bacteria, and the chemical diversity of compounds produced from marine sources has led to them being referred to as "blue gold" in the search for new drugs. For example, 80% of novel antibiotics stemming from the marine environment have come from Actinomycetes, many of which can be found associated with marine sponges, and compounds with anti-tumorigenic and anti-diabetic potential have also been isolated from marine symbionts. In fact, it has been estimated that marine sources formed the basis of over 50% of FDA-approved drugs between 1981 and2002. In this review, we explore the diversity of marine microbial symbionts by examining their use as the producers of novel pharmaceutical actives, together with a discussion of the opportunities and constraints offered by "blue gold" drug discovery.

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“…Sponges are sessile and soft-bodied, thus they have developed potent bioactive secondary metabolite defensive compounds [14] . Natural products found in or associated with sponges have pharmaceutical relevance due to their antitumor, antiviral, antimicrobial, and antiprotozoal properties [15,16] . …”

Section: Terpenoidsmentioning

confidence: 99%

Novel natural product discovery from obligate symbiotic organisms of marine sponges

Monaco

Quinlan

2018

J Nat Agents Mol Ther

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A rich source for the discovery of novel, pharmacologically active natural products have been the terrestrial plants and microbes, accounting for about 85% of the approved natural products in pharmaceutical use, and about 60% of approved pharmaceuticals and new drug applications submission annually. Discovery in the marine environment has lagged due to the difficulty of exploration in this ecological niche. Such exploration began in the 1950's, after technological advances such as scuba diving which allowed collection of marine organisms, primarily to a depth of about 15 m, which was the limit of that technology. Natural products from filter feeding marine invertebrates and in particular, sponges, have proven to be a rich source of structurally unique pharmacologically active compounds, with over 16,000 molecules isolated thus far and a continuing pace of discovery at hundreds of novel bioactive molecules per year. All classes of pharmaceuticals have been represented in this discovery process, including antiprotozoals, pesticides, TGF-beta inhibitors, cationic channel blockers, anticancer, cytotoxic, antiviral, anti-inflammatory and antibacterial compounds. Important biosynthetic pathways found in sponges which give rise to these compounds include the terpenoid, fatty acid, polyketoid, quinone reductase, alkaloid, isoprenoid, and non-ribosomal protein synthase pathways as summarized in this article.

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Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds

Cited by 158 publications

References 185 publications

Diversity and Bioactivity of Marine Bacteria Associated with the Sponges Candidaspongia flabellata and Rhopaloeides odorabile from the Great Barrier Reef in Australia

Diversity and Bioactivity of Marine Bacteria Associated with the Sponges Candidaspongia flabellata and Rhopaloeides odorabile from the Great Barrier Reef in Australia

Symbiotic Microbes from Marine Invertebrates: Driving a New Era of Natural Product Drug Discovery

Novel natural product discovery from obligate symbiotic organisms of marine sponges

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