Bioprospecting in Colombia

Suárez, Leonardo Güiza; Bernal, Diana

doi:10.11144/javeriana.sc18-2.bc

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Other sources of uncertainty include the strict Intellectual Property Rights-IPR instruments and norms implemented, which go against the policies strengthening open access in the country (Departamento Administrativo de Ciencia, Tecnología e Innovación-Colciencias, 2018), some calls for proposals for supporting technology transfer initiatives, where Innpulsa (the Colombian Public Agency in charge of Innovation and Entrepreneurship) competes with Colciencias, opening separate calls with very similar purposes, and the difference between the Colombian policy on biodiversity research and the procedure established to obtain a biodiversity research study permit, which has hindered biodiversity research activities (Güiza & Bernal, 2013).…”

Section: Colombian Contextmentioning

confidence: 99%

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆

Jaime

Pérez‐Martelo

Herrera

et al. 2022

Review of Policy Research

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We explore the strategies implemented by Research Groups' Leaders while coping with unstable contexts, characterized by incoherence and lack of coordination among different policy discourses and instruments, and scarce resources. We focus on a country where these conditions are present: Colombia. In doing so, we study two cases, one in nanotechnology and another one in biomedical engineering. Interviews, focus groups and workshops allowed us to identify and validate strategies grouped in four popular sayings, proper to local idiosyncrasy, highlighting the role of home institutions and principal investigators in facing such situations with resilience and resourcefulness, and even taking advantage of them. We find that Research Groups' Leaders use strategies such as: adapting, balancing agendas and funding sources, networking, and taking advantage of the support programs available at their home institution to continue functioning. These are setting the ground for a further survey which could pretend some generalization. However, policymakers could consider these findings when defining policy instruments or for assessing their effectiveness or impacts.

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Section: Colombian Contextmentioning

confidence: 99%

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆

Jaime

Pérez‐Martelo

Herrera

et al. 2022

Review of Policy Research

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Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population

Pérez

Flórez-Vargas

Cruz

et al. 2021

Sci Rep

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Mercury (Hg) vapor can produce kidney injury, where the proximal tubule region of the nephron is the main target of the Hg-induced oxidative stress. Hg is eliminated from the body as a glutathione conjugate. Thus, single nucleotide polymorphisms (SNPs) in glutathione-related genes might modulate the negative impact of this metal on the kidneys. Glutathione-related SNPs were tested for association with levels of Hg and renal function biomarkers between occupationally exposed (n = 160) and non-exposed subjects (n = 121). SNPs were genotyped by TaqMan assays in genomic DNA samples. Total mercury concentration was measured in blood, urine and hair samples. Regression analyses were performed to estimate the effects of SNPs on quantitative traits. Alleles GCLM rs41303970-T and GSTP1 rs4147581-C were significantly overrepresented in the exposed compared with the non-exposed group (P < 0.01). We found significant associations for GCLM rs41303970-T with higher urinary clearance rate of Hg (β = 0.062, P = 0.047), whereas GCLC rs1555903-C was associated with lower levels of estimated glomerular filtration rate in the non-exposed group (eGFR, β = − 3.22, P = 0.008) and beta-2-microglobulin in the exposed group (β-2MCG, β = − 19.32, P = 0.02). A SNP-SNP interaction analysis showed significant epistasis between GSTA1 rs3957356-C and GSS rs3761144-G with higher urinary levels of Hg in the exposed (β = 0.13, P = 0.04) but not in the non-exposed group. Our results suggest that SNPs in glutathione-related genes could modulate the pathogenesis of Hg nephrotoxicity in our study population by modulating glutathione concentrations in individuals occupationally exposed to this heavy metal.

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Bioprospecting in Colombia

Cited by 2 publications

References 12 publications

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆

Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population

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Bioprospecting in Colombia

Cited by 2 publications

References 12 publications

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities☆

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities☆

Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population

Contact Info

Product

Resources

About

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆

Functioning strategies of the research groups' leaders in the context of funding and policy instabilities^☆