The Drosophila adult male terminalia originate from the genital disc. During the pupal stages, the external parts of terminalia evert from two ventral stalks; the everted left and right dorsal halves fuse at the dorsal midline. At the same time the male terminalia perform a 360º clockwise rotation. Several mutations are known to affect the rotation of the male terminalia, while none is known to affect dorsal closure. We show here that the Pvf1 gene, encoding one of the three Drosophila homologues of the mammalian VEGF/PDGF growth factors, is required for both processes. Males either mutant for Pvf1 or bearing a dominant negative form of Pvr or stasis (stai), the unique PVF receptor, do not complete either rotation or dorsal closure. Pvf1 expression in the genital disc is restricted to the A8 cells. However, PVF1/PVR signaling influences A8, A9 and A10 cells, suggesting that the PVF1 protein diffuses from its source. Flies hemizygous for the apoptotic genes hid, reaper and grim, or mutant for puckered which encodes a phosphatase that downregulates the n-Jun-N terminal kinase pathway, lead to the same phenotypes as mutations in PVF1/ PVR. Our results indicate that PVF1/PVR signaling functions not only in apoptotic phenomena but are also required during rotation and dorsal closure of the Drosophila male genital disc.
El presente artículo se desarrolló en el marco del Convenio de Asociación No. 1257 de 2014 suscrito entre la Corporación Autónoma Regional de Cundinamarca (CAR) y el Colegio Mayor de Nuestra Señora del Rosario, con el fin de aunar esfuerzos para adelantar la segunda fase del proyecto "Hacia un observatorio de agendas interinstitucionales y conflictos socio-ambientales con enfoque de derechos humanos en el territorio de la Corporación".
consequences that generate the high consumption of mercury in gold mining activities is an international country's gold mines have no mining title and only and environmental lawlessness, the failures of importation controls on the supply are the cause of the high consumption of mercury in Colombian evidenced the miners' partiality in favor of the use of mercury in the procurement of gold; the process is government has opted for a policy of persecution of the activity rather than the promotion of their
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