Biopolymers – Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering

Cojocaru, Florina-Daniela; Bǎlan, Vera; Popa, Marcel; Lobiuc, Andrei; Antoniac, Aurora; Antoniac, Iulian Vasile; Vereştiuc, Liliana

doi:10.1016/j.ijbiomac.2018.12.083

Cited by 66 publications

(39 citation statements)

References 46 publications

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“…The scaffolds improved the mechanical properties and the formation of crystals in the SBF, and it had a good biocompatibility and could maintain the cell growth [ 72 ]. Moreover, gelatin, a protein derived from collagen with a similar structure to collagen, is a biodegradable biopolymer with a high biocompatibility [ 115 ], which has also been widely used in biomimetic composite scaffolds with chitosan [ 91 , 116 , 117 ]. A gelatin-chitosan core-shell structured nanofibers mat with a three-dimensional porous structure was fabricated by a coaxial electrospinning technique.…”

Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

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Section: Applications Of Chitosan-based Biomimetically Mineralizedmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

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“…Composites of chitosan and magnetite NPs are combined with different biopolymers (hyaluronic acid, bovine serum albumin, gelatin) and subjected towards a biomimetic co-precipitation with CaP. The resulting materials exhibit a porous structure, are resistant towards biodegradation and have no cytotoxic effect on MC3T3-E1 preosteoblastic cells and thus are potential candidates for further studies in the field of BTE [148]. A magnetite-containing scaffold from silk fibroin and chitosan, cross-linked with glutaraldehyde, was prepared using freeze-casting.…”

Section: Miscellaneous Additivesmentioning

confidence: 99%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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“…IO-NPs were also incorporated into polymeric scaffolds which were fabricated via electrospinning [133], or via composite fabrication [134] and 3D printing [135,136]. Biocompatible polymers explored so far include PLA [137], poly(lactic-co-glycolic acid) (PCL) [138], poly(urethane) [139], and chitosan [134]. A drawback for polymer-based scaffolds is their low mechanical strength.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

Jansman

Hosta‐Rigau

2019

Catalysts

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Nanoparticulate materials displaying enzyme-like properties, so-called nanozymes, are explored as substitutes for natural enzymes in several industrial, energy-related, and biomedical applications. Outstanding high stability, enhanced catalytic activities, low cost, and availability at industrial scale are some of the fascinating features of nanozymes. Furthermore, nanozymes can also be equipped with the unique attributes of nanomaterials such as magnetic or optical properties. Due to the impressive development of nanozymes during the last decade, their potential in the context of tissue engineering and regenerative medicine also started to be explored. To highlight the progress, in this review, we discuss the two most representative nanozymes, namely, cerium- and iron-oxide nanomaterials, since they are the most widely studied. Special focus is placed on their applications ranging from cardioprotection to therapeutic angiogenesis, bone tissue engineering, and wound healing. Finally, current challenges and future directions are discussed.

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Biopolymers – Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering

Cited by 66 publications

References 46 publications

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

Cerium- and Iron-Oxide-Based Nanozymes in Tissue Engineering and Regenerative Medicine

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