Biopolymers as Wound Healing Materials: Challenges and New Strategies

Sezer, Ali Demir; Cevher, Erdal

doi:10.5772/25177

Cited by 23 publications

(11 citation statements)

References 132 publications

(154 reference statements)

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“…is called a partial thickness wound, while damage to the subcutaneous fat layer is called a full thickness wound and it leads to extensive loss of skin, hair follicles, and glands [3]. There are many studies that are applied with extensive research to the treatment of partial and full-thickness wounds using different materials made of porous foams, hydrogels, or nanofibrous layers of synthetic materials (poly(ethylene glycol) (PEG), poly(ε-caprolactone) (PCL), poly(lactic-coglycolic acid) (PLGA), poly(lactic acid) (PLA), poly(vinyl alcohol) (PVA), polyurethane films, or silk fibroin) [4][5][6] and/or natural materials based on collagen (Coll), gelatin (Gel), cellulose, alginate, chitosan, hyaluronan, fibrin or fucoidan materials [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Accelular nanofibrous bilayer scaffold intrapenetrated with polydopamine network and implemented into a full-thickness wound of a white-pig model affects inflammation and healing process

et al. 2023

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Treatment of complete loss of skin thickness requires expensive cellular materials and limited skin grafts used as temporary coverage. This paper presents an acellular bilayer scaffold modified with polydopamine (PDA), which is designed to mimic a missing dermis and a basement membrane (BM). The alternate dermis is made from freeze-dried collagen and chitosan (Coll/Chit) or collagen and a calcium salt of oxidized cellulose (Coll/CaOC). Alternate BM is made from electrospun gelatin (Gel), polycaprolactone (PCL), and CaOC. Morphological and mechanical analyzes have shown that PDA significantly improved the elasticity and strength of collagen microfibrils, which favorably affected swelling capacity and porosity. PDA significantly supported and maintained metabolic activity, proliferation, and viability of the murine fibroblast cell lines. The in vivo experiment carried out in a domestic Large white pig model resulted in the expression of pro-inflammatory cytokines in the first 1–2 weeks, giving the idea that PDA and/or CaOC trigger the early stages of inflammation. Otherwise, in later stages, PDA caused a reduction in inflammation with the expression of the anti-inflammatory molecule IL10 and the transforming growth factor β (TGFβ1), which could support the formation of fibroblasts. Similarities in treatment with native porcine skin suggested that the bilayer can be used as an implant for full-thickness skin wounds and thus eliminate the use of skin grafts.

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Section: Introductionmentioning

confidence: 99%

Accelular nanofibrous bilayer scaffold intrapenetrated with polydopamine network and implemented into a full-thickness wound of a white-pig model affects inflammation and healing process

et al. 2023

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“…They can easily fill wound cavities as a result of their flowable properties and support the maintenance of a physiological moist environment [14,[61][62][63][64]. Other forms of wound dressings include transparent films ranging from µm to mm in thickness to flexibly cover the wounds [65][66][67][68]. An optimal wound dressing material must appropriately respond to the wound target's characteristics, such as its size and exudate amount.…”

Section: Biopolymers In Wound Dressingsmentioning

confidence: 99%

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Luca¹,

Pedram

Moeini

et al. 2021

Applied Sciences

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Wound healing refers to the replacement of damaged tissue through strongly coordinated cellular events. The patient’s condition and different types of wounds complicate the already intricate healing process. Conventional wound dressing materials seem to be insufficient to facilitate and support this mechanism. Nanotechnology could provide the physicochemical properties and specific biological responses needed to promote the healing process. For nanoparticulate dressing design, growing interest has focused on natural biopolymers due to their biocompatibility and good adaptability to technological needs. Polysaccharides are the most common natural biopolymers used for wound-healing materials. In particular, alginate and chitosan polymers exhibit intrinsic antibacterial and anti-inflammatory effects, useful for guaranteeing efficient treatment. Recent studies highlight that several natural plant-derived molecules can influence healing stages. In particular, essential oils show excellent antibacterial, antifungal, antioxidant, and anti-inflammatory properties that can be amplified by combining them with nanotechnological strategies. This review summarizes recent studies concerning essential oils as active secondary compounds in polysaccharide-based wound dressings.

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“…It should also provide pain relief and a moist wound environment, protection against mechanical, bacterial, infectious, and thermal factors; moreover, it should exhibit debridement activity, non-antigenic and non-toxic properties, high excess exudate absorption, and healing/re-epithelialization capability. One of the most used materials that sum up most of these benefits are biopolymers because they are biodegradable and bioactive, and they promote tissue regeneration and wound healing through cell migration and proliferation [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. “Smart” biomaterials can be used in 4D bioprinting, drug delivery, regenerative medicine, soft electronics, and even for artificial lives and synthetic biology [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Carrageenan-Based Compounds as Wound Healing Materials

Neamţu

Barbu

Negrea

et al. 2022

IJMS

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The following review is focused on carrageenan, a heteroglycan-based substance that is a very significant wound healing biomaterial. Every biomaterial has advantages and weaknesses of its own, but these drawbacks are typically outweighed by combining the material in various ways with other substances. Carrageenans’ key benefits include their water solubility, which enables them to keep the wound and periwound damp and absorb the wound exudate. They have low cytotoxicity, antimicrobial and antioxidant qualities, do not stick to the wound bed, and hence do not cause pain when removed from the wounded region. When combined with other materials, they can aid in hemostasis. This review emphasizes the advantages of using carrageenan for wound healing, including the use of several mixes that improve its properties.

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Biopolymers as Wound Healing Materials: Challenges and New Strategies

Cited by 23 publications

References 132 publications

Accelular nanofibrous bilayer scaffold intrapenetrated with polydopamine network and implemented into a full-thickness wound of a white-pig model affects inflammation and healing process

Accelular nanofibrous bilayer scaffold intrapenetrated with polydopamine network and implemented into a full-thickness wound of a white-pig model affects inflammation and healing process

Nanotechnology Development for Formulating Essential Oils in Wound Dressing Materials to Promote the Wound-Healing Process: A Review

Carrageenan-Based Compounds as Wound Healing Materials

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