Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity

Divya, Mani; Vaseeharan, Baskaralingam; Abinaya, M.; Vijayakumar, Sekar; Govindarajan, Marimuthu; Alharbi, Naiyf S.; Kadaikunnan, Shine; Khaled, Jamal M.; Benelli, Giovanni

doi:10.1016/j.jphotobiol.2017.11.008

Cited by 133 publications

(59 citation statements)

References 39 publications

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“…Zinc oxide nanomaterials coated or not with different molecules were tested for their ability to prevent the biofilm formation of C. albicans . For example, zinc oxide nanoparticles that were coated with biopolymer gelatin or chitosan-linoleic acid led to a weak adherence of biofilm formation [ 62 , 63 ]. Moreover, it was found that ZnO-NPs had a toxic effect on C. albicans biofilm inducing alterations in the extracellular matrix [ 53 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Candidal Activity and In Vitro Cytotoxicity Assessment of Graphene Nanoplatelets Decorated with Zinc Oxide Nanorods

et al. 2018

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Candida albicans is the most common pathogenic fungus that is isolated in nosocomial infections in medically and immune-compromised patients. The ability of C. albicans to convert its form from yeast to hyphal morphology contributes to biofilm development that effectively shelters Candida against the action of antifungals molecules. In the last years, nanocomposites are the most promising solutions against drug-resistant microorganisms. The aim of this study was to investigate the antifungal activity of graphene nanoplateles decorated with zinc oxide nanorods (ZNGs) against the human pathogen Candida albicans. We observed that ZNGs were able to induce a significant mortality in fungal cells, as well as to affect the main virulence factors of this fungus or rather the hyphal development and biofilm formation. Reactive Oxygen Species (ROS) formation in yeast cells resulted one of the mechanisms of ZNGs to induce mortality. Finally, the toxicity of this nanomaterial was tested also on human keratinocyte cell line HaCaT. Our data indicated that ZNGs resulted not toxic when their aggregation state decreased by adding glycerol as emulsifier to ZNGs suspensions or when HaCaT cells were grown on ZNGs-coated glasses. Overall, the results that were obtained indicated that ZNGs could be exploited as an antifungal nanomaterial with a high degree of biocompatibility on human cells.

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Section: Resultsmentioning

confidence: 99%

Anti-Candidal Activity and In Vitro Cytotoxicity Assessment of Graphene Nanoplatelets Decorated with Zinc Oxide Nanorods

et al. 2018

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“…As biointeractive fillers, nanosized ZnO particles can enable mineral growth via bioactivity and negatively affect metalloproteinases and bacteria growth [8][9][10]. Particles with nanometer-sizes present a high surface area and increased surface reactivity due to a higher percentage of atoms on the material's surface [11].…”

Section: Introductionmentioning

confidence: 99%

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

et al. 2020

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This study aimed to evaluate the effect of needle-like zinc oxide nanostructures (ZnO-NN) on the physical, chemical, and antibacterial properties of experimental methacrylate-based dental sealers. ZnO-NN was synthesized and characterized. ZnO-NN was added to a co-monomer blend at 20, 30, and 40 wt.%. One group without ZnO-NN was used as a control. The dental resin sealers were evaluated for their flow, film thickness, water sorption, solubility, radiopacity, degree of conversion (DC), dental-sealer interface characterization via micro-Raman, and antibacterial activity. ZnO-NN presented a mean needle diameter of 40 nm and 16 m2/g of surface area. There was no difference among groups containing ZnO-NN regarding their flow. The ZnO-NN addition significantly increased the film thickness. Water sorption and solubility tests showed no difference among groups. The radiopacity increased, and DC decreased with higher concentrations of ZnO-NN. Micro-Raman suggested that ZnO-NN was in close contact with root canal dentin. Overall, the incorporation of ZnO-NN provided an antibacterial effect against Enterococcus faecalis without a significant detrimental impact on the physical and chemical functionality of the material. The use of ZnO-NN as an inorganic filler is a potential application within dental materials intended for root canal treatment.

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“…The antimicrobial activity by zinc oxide (ZnO) particles were proposed due to emission of zinc ions (Zn 2+ ), which are able to penetrate into the bacteria's cell wall and affect the cytoplasmic content in the cell that leads to the death of bacteria. The incorporation of zinc oxide nanoparticles into gelatin was observed by Divya et al [66] which revealed that the film showed higher inhibitory effect against Gram-negative bacteria (Pseudomonas aeruginosa) than Gram-positive (Enterococcus faecalis) bacteria. The results corresponded with the statement which suggested that ZnO induced photocatalytic mechanism related to the semiconductive properties of ZnO which lead to the formation of reactive oxygen species (ROS) and H 2 O 2 which damaged the cell wall structure of bacteria [67,68].…”

Section: Zinc Particles As Antimicrobial Agentsmentioning

confidence: 95%

Protein-Based Active Film as Antimicrobial Food Packaging: A Review

Said¹,

Sarbon²

2019

Active Antimicrobial Food Packaging

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This review discusses the protein-based active film as antimicrobial food packaging derived from various sources such as gelatin, casein, whey and zein-based protein. The films properties that exhibit antimicrobial activity are being reviewed along with their application in food packaging industry. This paper also studies the inhibition activity by antimicrobial agents from organic and metallic sources which were incorporated into the protein-based film. Nowadays, protein-based film has emerged as one of the most extensively studied in food packaging sector as it exhibits good mechanical, optical, and oxygen barrier properties. In addition, protein-based film also showed good compatibility to polar surfaces while having effective control on the release of additives and bioactive compounds in food packaging system. This paper also detailed out information on antimicrobial food packaging in order to increase consumer awareness regarding food safety and healthy lifestyle while maintaining the quality and prolonged the shelf life of food product.

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Biopolymer gelatin-coated zinc oxide nanoparticles showed high antibacterial, antibiofilm and anti-angiogenic activity

Cited by 133 publications

References 39 publications

Anti-Candidal Activity and In Vitro Cytotoxicity Assessment of Graphene Nanoplatelets Decorated with Zinc Oxide Nanorods

Anti-Candidal Activity and In Vitro Cytotoxicity Assessment of Graphene Nanoplatelets Decorated with Zinc Oxide Nanorods

Exploring Needle-Like Zinc Oxide Nanostructures for Improving Dental Resin Sealers: Design and Evaluation of Antibacterial, Physical and Chemical Properties

Protein-Based Active Film as Antimicrobial Food Packaging: A Review

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