Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering

Song, Jian; Winkeljann, Benjamin; Lieleg, Oliver

doi:10.1002/admi.202000850

Cited by 92 publications

(68 citation statements)

References 290 publications

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“…Here, the thickness of the coating was achieved by rotation speed, viscosity and surface tension. Very recently, Song et al reviewed various biopolymer based coating methods [ 13 ].…”

Section: Biopolymer Coating Methodsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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Biopolymer coatings exhibit outstanding potential in various biomedical applications, due to their flexible functionalization. In this review, we have discussed the latest developments in biopolymer coatings on various substrates and nanoparticles for improved tissue engineering and drug delivery applications, and summarized the latest research advancements. Polymer coatings are used to modify surface properties to satisfy certain requirements or include additional functionalities for different biomedical applications. Additionally, polymer coatings with different inorganic ions may facilitate different functionalities, such as cell proliferation, tissue growth, repair, and delivery of biomolecules, such as growth factors, active molecules, antimicrobial agents, and drugs. This review primarily focuses on specific polymers for coating applications and different polymer coatings for increased functionalization. We aim to provide broad overview of latest developments in the various kind of biopolymer coatings for biomedical applications, in order to highlight the most important results in the literatures, and to offer a potential outline for impending progress and perspective. Some key polymer coatings were discussed in detail. Further, the use of polymer coatings on nanomaterials for biomedical applications has also been discussed, and the latest research results have been reported.

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“…Here, the thickness of the coating was achieved by rotation speed, viscosity and surface tension. Very recently, Song et al reviewed various biopolymer based coating methods [ 13 ].…”

Section: Biopolymer Coating Methodsmentioning

confidence: 99%

Biopolymer Coatings for Biomedical Applications

Nathanael

2020

Polymers

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“…Among them, one should mention the copolymer composition [ 137 ], morphology [ 138 ], autocatalysis by acidic degradation products inside a matrix [ 139 ], presence of drugs [ 140 ], and preparation technique [ 141 ]. Hydrophilicity–hydrophobicity balance, the structure and molecular weight of the polymer can also predetermine the degradation behavior [ 142 ]. Moreover, the environmental conditions such as temperature, the presence of other additives in the polymer, pH, humidity, oxygen, the amount and the microbial strains, salinity, or exposure to external influences (e.g., UV, X-ray, γ-ray, ion beams, or mechanical strain) could also have a great influence [ 142 ].…”

Section: Degradation Mechanismsmentioning

confidence: 99%

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

2021

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The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

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“…Antibiotics, alone or in combination with other antimicrobial compounds, have been proposed as local release strategies by embedding or immobilizing onto implant coatings [ 13 ]. Several coating techniques involving biocompatible synthetic/natural polymers or ceramics nanostructures and antibiotics have been investigated [ 85 ]. Among naturally and synthetically polymers commonly used there are CS, Coll, PDLLA, PLA, PLGA, poly(β-amino esters)/poly(acrylic acid), and poly(ethylene glycol)-poly(lactic-co-caprolactone) [ 85 ].…”

Section: Passive and Active Antibiofilm Treatmentsmentioning

confidence: 99%

“…Several coating techniques involving biocompatible synthetic/natural polymers or ceramics nanostructures and antibiotics have been investigated [ 85 ]. Among naturally and synthetically polymers commonly used there are CS, Coll, PDLLA, PLA, PLGA, poly(β-amino esters)/poly(acrylic acid), and poly(ethylene glycol)-poly(lactic-co-caprolactone) [ 85 ].…”

Section: Passive and Active Antibiofilm Treatmentsmentioning

confidence: 99%

Trends in Managing Cardiac and Orthopaedic Device-Associated Infections by Using Therapeutic Biomaterials

et al. 2021

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Over the years, there has been an increasing number of cardiac and orthopaedic implanted medical devices, which has caused an increased incidence of device-associated infections. The surfaces of these indwelling devices are preferred sites for the development of biofilms that are potentially lethal for patients. Device-related infections form a large proportion of hospital-acquired infections and have a bearing on both morbidity and mortality. Treatment of these infections is limited to the use of systemic antibiotics with invasive revision surgeries, which had implications on healthcare burdens. The purpose of this review is to describe the main causes that lead to the onset of infection, highlighting both the biological and clinical pathophysiology. Both passive and active surface treatments have been used in the field of biomaterials to reduce the impact of these infections. This includes the use of antimicrobial peptides and ionic liquids in the preventive treatment of antibiotic-resistant biofilms. Thus far, multiple in vivo studies have shown efficacious effects against the antibiotic-resistant biofilm. However, this has yet to materialize in clinical medicine.

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Biopolymer‐Based Coatings: Promising Strategies to Improve the Biocompatibility and Functionality of Materials Used in Biomedical Engineering

Cited by 92 publications

References 290 publications

Biopolymer Coatings for Biomedical Applications

Biopolymer Coatings for Biomedical Applications

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

Trends in Managing Cardiac and Orthopaedic Device-Associated Infections by Using Therapeutic Biomaterials

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