Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review

Shah, Syed Ahmed; Sohail, Muhammad; Khan, Shahzeb; Minhas, Muhammad Usman; Matas, Marcel de; Sikstone, Victoria; Hussain, Zahid; Abbasi, Mudassir; Kousar, Mubeen

doi:10.1016/j.ijbiomac.2019.08.007

Cited by 193 publications

(110 citation statements)

References 254 publications

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“…Modern dressings are mainly classified according to the materials they are produced, usually in the form of hydrogel, film and foam board . In addition to sealing wounds to prevent fluid loss and the accumulation of purulent substances, hydrogel dressings can also prevent crust‐forming organisms from promoting bacterial growth and infection, and are now recognized as the best chronic wound treatment materials . Since Rosick et al invented the hydrogel for wound dressing in 1989, researchers have continuously modified them to improve their physicochemical properties.…”

Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

399

255

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The accelerating and thorough treatment of chronic wounds still represents a major unmet medical need owing to the complex symptoms resulting from metabolic disorder of the wound microenvironment. Although numerous strategies and bioactive hydrogels are developed, an effective and widely used method of chronic wound treatment remains a bottleneck. With the aim to accelerate chronic wound healing, many hydrogel dressings with antioxidant functions have emerged and are proven to accelerate wound healing, especially for chronic wound repair. The new strategy in chronic wound treatment brought by antioxidant hydrogels is of great significance to human health. Here, the application of antioxidant hydrogels in the repair of chronic wounds is discussed systematically, aiming to provide an important theoretical reference for the further breakthrough of chronic wound healing.

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Section: Causes and Healing Of Woundsmentioning

confidence: 99%

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Han

et al. 2020

Adv Healthcare Materials

399

255

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“…Fibroplasia and the revascularization of the wound take place at the same time, and the combination of migration and proliferation results in the formation of angiogenesis process. Angiogenesis emerges at the site of vessels near to the wound and consists of stimulating the migration of endothelial cells [ 4 ]. The mediators for chemotaxis and endothelial cell growth are the cytokines produces by macrophages, platelets, and lymphocytes from the wound location [ 24 ].…”

Section: Wound Healingmentioning

confidence: 99%

“…Endothelial cells, macrophages, and myofibroblasts can exit the wound area, while the remaining ones undergo the apoptosis process. The formation of other matrix components that comprise glycosaminoglycan and fibroblasts can also take place in this step, though fibrillar collagen type I (80–90%) and reticular collagen type III (10–20%) are the principal components of the intact dermis [ 4 ]. All the stages initiated in the previous steps of wound healing will finish when remodeling occurs and when the scar formation takes place [ 26 ].…”

Section: Wound Healingmentioning

confidence: 99%

“…It is well known that all living organisms regenerate as part of natural processes to preserve tissues and/or organs, but mammals have restricted regenerative abilities, including forming thick scars in skin and tissues, which supports the healing process [ 2 ]. Therefore, the complex process of damaged tissues restoration involves several overlapping steps: Influx of inflammatory cells and collagen formation, cytokine actions, depositions of the extracellular matrix (ECM) and cellular reorganization with scar appearance [ 3 , 4 ]. Despite numerous researches being conducted in recent years aiming at the formulation of wound dressing biomaterials, no currently available material fulfills the needed characteristics for a speedy and improved recovery of injured tissues.…”

Section: Introductionmentioning

confidence: 99%

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An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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“…An attractive approach in modern wound care is the combination between healing dressings and antimicrobial agents. Superior results were reported when embedding antimicrobials within different wound dressings, including commercial antibiotics, natural-derived antimicrobial agents and metal or oxide nanoparticles [31,32]. Based on the currently available data, it can be certainly stated that antimicrobial dressings have beneficial effects in fighting pathogens and combating microbial biofilms in chronic ulcers wounds [33,34].…”

Section: Wound Care and Dressingsmentioning

confidence: 99%

The importance of oxygen release in diabetic foot ulcer wounds

2019

Bioengineering Int

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Oxygen is the essential element required for proper physiological function of cells, tissues and organs within healthy human body. Thanks to its intricate structure, the skin provides a multiprotective barrier against traumatic and non-traumatic injuries, but also a complex and successful self-healing process of the affected tissue. In the particular case of chronic skin wounds, such as diabetic foot ulcer wounds, there is an immediate demand to develop alternative procedures that prevent infection, speed up healing and eliminate any disrupting factor that may interfere with the therapeutic process. Given the importance of oxygen during wound healing cascade, impressive attention was oriented towards the fabrication of oxygen-releasing wound dressings.

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Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review

Cited by 193 publications

References 254 publications

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

The importance of oxygen release in diabetic foot ulcer wounds

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