Biophysical probing of antibacterial Gemifloxacin assimilated in surfactant mediated molecular assemblies

Physicochemical investigation of antibacterial Moxifloxacin interacting with quaternary ammonium disinfectants

“…The dimensionless partition coefficient K x is related to K c as K x = K c. n w , where n w is the number of moles of water per dm 3 (55.55 mol dm −3 ), and is reported in Table 1. The values of K x for MOF were found comparable with the reported literature values for some fluoroquinolone molecules partition to ionic micelles [54,55]. The standard Gibbs energy change of the transfer (°p ∆G ) of MOF molecules from bulk aqueous phase to micellar region can be calculated using the following relation:…”

Impact of l-leucine on controlled release of ciprofloxacin through micellar catalyzed channels in aqueous medium

“…The values of K x for CIP were found comparable with the reported literature values for some fluoroquinolone molecules partition to ionic micelles [12,17,26]. The standard Gibbs energy change of the transfer (ΔG p°) of CIP molecules from bulk aqueous phase to micellar region can be calculated using the following relation: Table 2 Values of K c , K x , K b , ΔG p°a nd ΔG b°o f CIP −surfactants.…”

“…Yang et al studied the effect of surfactants, cyclodextrins and pH on the fluorescence profile of CIP and have shown that the three acid constant of CIP are very close to each other due to which and there is not much effect on the fluorescence intensity of CIP in the pH range of 2-7 [9]. In other studies, the micellar effect is utilized for the effective determination of CIP and some other fluoroquinolones [14][15][16][17].…”

Spectral-luminescent properties of pH-sensitive azo fluorophore in complexes with quaternary ammonium disinfectants

“…Since the negative charge increases with pH, it might lead to the complete ionization of carboxylic acid group of the AHABA molecules. In addition, the increase of alkyl length in the head group of cationic surfactant causes the reduction in CMC and hence decreases the degree of counter-ion binding with a concomitant increase in the degree of ionization [44,46,47]. The observed decrease in the degree of the counter-ion binding ( Table 2) with increasing alkyl length of head group (i.e., EHDAB as compared to CTAB) was presumably due to the increased hydrophobic character of the surfactant molecule.…”

“…To locate the active sites for electrophilic and nucleophilic attack, the relative polarity and reactivity of AHABA molecule/ion were estimated by molecular electrostatic potential (MEP) and frontier molecular orbital (FMO) energy calculations, since MEP and FMO are handy tools to evaluate the structure-reactivity relationship and chemical stability of the molecules [34][35][36][37][38]. Moreover, to get site-specific affinity and biophysical insight into the molecular distribution of AHABA in colloidal fluid, the spectral behavior of this active azo moiety in association with Quats was analyzed by using excitation and emission spectroscopic measurements given that the ionic surfactants have a profound effect on the spectral behavior of numerous organic molecules [39][40][41][42][43][44][45][46][47].…”