Physicochemical investigation of antibacterial Moxifloxacin interacting with quaternary ammonium disinfectants

Nazar, Muhammad Faizan; Mukhtar, Fareeha; Ashfaq, Muhammad; Rahman, Hafiz Muhammad Abd Ur; Zafar, Muhammad; Sumrra, Sajjad Hussain

doi:10.1016/j.fluid.2015.07.033

Cited by 24 publications

(14 citation statements)

References 73 publications

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“…A bathochromic shift was observed in the spectrum of BNP/SDS solution, which indicates a strong host-guest relationship between these two species. However, attraction between opposite charges does not allow BNP molecules to penetrate deep [15][16][17][18][19]. Figure 2b shows an increase in the absorbance of BNP with SDS concentration until the CMC is reached.…”

Section: Resultsmentioning

confidence: 99%

“…A positive charge on the sulphur atom of BNP develops strong electrostatic interactions with the anionic groups on the SDS. The environment around BNP molecules changes with SDS concentration till the CMC, while after the CMC, no change in environment takes place and, thus, no change in absorbance [15][16][17][18][19][20][21][22][23]. Later on, this absorbance leveled off after reaching a certain value due to the maximum incorporation of BNP into the micelles [9][10][11][12][13][14].…”

Section: Resultsmentioning

confidence: 99%

“…3 [16][17][18][19]. 3, C a and C s indicate the concentration of additive and surfactant, respectively.…”

Section: Parameters Calculatedmentioning

confidence: 99%

“…It might have gone relatively deeper in the palisade layer with less available space and, therefore, displayed a lower partition coefficient[15][16][17][18][19][20][21][22][23][24][25]. This interaction causes it first to be adsorbed on the surface, as shown in Scheme 4a, and then it is accommodated inside the micelle as evident from 4(b).…”

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confidence: 99%

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Spectroscopic study of benzothiophene partitioning in sodium dodecyl sulfate and cetyl trimethyl ammonium bromide micellar media

Hanif

Usman

Hussain

et al. 2016

J Surfact & Detergents

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This manuscript reports the partitioning of benzothiophene (BNP), a bioactive organic compound, between the aqueous phase and micellar media of an anionic surfactant, sodium dodecyl sulphate (SDS) and a cationic surfactant, cetyl trimethyl ammonium bromide (CTAB). Simple and differential UV/visible spectroscopic studies of said systems have been conducted in premicellar and post‐micellar concentration ranges. The experimental results reveal that in the premicellar region, the molecules of BNP get attached with monomeric surfactant molecules, while in the post‐micellar region; they are accommodated within the micelle. The bathochromic shift is observed in the UV/visible spectra of BNP in the presence of both surfactants. The water/micelle partition coefficient (Kx) and binding constant (Kb) were calculated using differential absorption data and subsequently the values of free energy of partition (∆Gp) and free energy of binding (∆Gb) were calculated. The values of Kx show that the solubilization of BNP is more spontaneous and takes place to a greater extent in micellar media of SDS than in CTAB.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…3 [16][17][18][19]. 3, C a and C s indicate the concentration of additive and surfactant, respectively.…”

Section: Parameters Calculatedmentioning

confidence: 99%

mentioning

confidence: 99%

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Spectroscopic study of benzothiophene partitioning in sodium dodecyl sulfate and cetyl trimethyl ammonium bromide micellar media

Hanif

Usman

Hussain

et al. 2016

J Surfact & Detergents

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“…Since, in collisional quenching only the excited states of the fluorophores are affected, no changes in the absorption spectra were observed. However, in the ground-state complex formation, the perturbation of the absorption spectrum of the fluorophore has been frequently observed earlier [31][32][33].…”

Section: Steady-state Fluorescence Spectroscopy Studymentioning

confidence: 91%

Impact of l-leucine on controlled release of ciprofloxacin through micellar catalyzed channels in aqueous medium

Nazar

Abid

Danish

et al. 2015

Journal of Molecular Liquids

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Gatifloxacin–Ionic Surfactant Interactions: Volumetric, Acoustic, Voltammetric, and Spectroscopic Studies

Sohail

Rahman²,

Asghar

2020

J Surfact & Detergents

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Surfactant systems have been frequently used as pseudomodels for investigating interactions of drugs with biological membranes because of their structural similarities with the latter. This helps to understand complicated yet very important biological processes like diffusion of bioactive moieties through biomembranes. The current study deals with voltammetric and spectroscopic studies to evaluate the interaction of a potential antibacterial drug, gatifloxacin (GTF), with a cationic surfactant, dodecyltrimethylammonium bromide (DTAB), and an anionic surfactant, sodium dodecyl sulfate (SDS), under physiological conditions (phosphate buffer, pH 7.4). For more detailed insight into the GTF–ionic surfactant interactions, density and acoustic data were also recorded and used to calculate several important parameters, namely, apparent molar volume (ɸV), isentropic compressibility (Ks), and apparent molar isentropic compressibility (ɸK) at T = 298.15, 303.15, 308.15, and 313.15 K. Values for partial molar volume (ɸVofalse), partial molar expansivity ()ɸEo, specific acoustic impedance (Z), relative association (RA), intermolecular free length (Lf), and sound velocity number (U) were also obtained. The interpretation of the concentration dependence of the above‐mentioned quantities using a cosphere overlap model led to a better apprehension of solute–solute and solute–solvent intermolecular interactions present in the investigated system, whereas cyclic voltammetry and ultra violet (UV)–visible spectroscopic studies assisted in predicting the location of adsorbed GTF molecules within the DTAB and SDS micelles.

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Physicochemical investigation of antibacterial Moxifloxacin interacting with quaternary ammonium disinfectants

Cited by 24 publications

References 73 publications

Spectroscopic study of benzothiophene partitioning in sodium dodecyl sulfate and cetyl trimethyl ammonium bromide micellar media

Spectroscopic study of benzothiophene partitioning in sodium dodecyl sulfate and cetyl trimethyl ammonium bromide micellar media

Impact of l-leucine on controlled release of ciprofloxacin through micellar catalyzed channels in aqueous medium

Gatifloxacin–Ionic Surfactant Interactions: Volumetric, Acoustic, Voltammetric, and Spectroscopic Studies

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