Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

Elkholy, Nourhan S; Shafaa, Medhat W.; Mohammed, Haitham S.

doi:10.1039/d0ra05683a

Cited by 18 publications

(14 citation statements)

References 65 publications

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“…35 The range of 3020-2840 cm À1 represents the lipids' characterization and contains the CH bands. [36][37][38][39][40][41] The normalized absorbances (Norm. Abs.)…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

et al. 2021

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“…35 The range of 3020-2840 cm À1 represents the lipids' characterization and contains the CH bands. [36][37][38][39][40][41] The normalized absorbances (Norm. Abs.)…”

Section: Ftir Spectroscopymentioning

confidence: 99%

Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

et al. 2021

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“…Xanthan gum-coated liposome has shown high retention ability for encapsulated β-carotene (2 molar β-carotene) during 90 days of storage under refrigerated conditions [ 119 ]. L -α-Dipalmitoylphosphatidylcholine-based liposomes was evaluated for release of β-carotene in simulated digestive system and it was observed that only 5% gum Arabic concentration 10% of total encapsulated β-carotene was released under gastric digestion conditions while 30–40% of total encapsulated β-carotene was released under intestinal digestive fluid [ 315 ]. Liposomes have also been reported improved stability for encapsulated β-carotene [ 117 , 118 , 119 , 120 , 121 , 122 , 123 ].…”

Section: Delivery Systems For β-Carotenementioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

et al. 2021

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Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e., small size, high surface area, unique composition, biocompatibility and biodegradability, make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers have some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has rapidly evolved, with a plethora of innovative nanoengineered materials now being in use, including micelles, nano/microemulsions, liposomes, niosomes, solidlipid nanoparticles, nanostructured lipids and nanostructured carriers. These nanodelivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nanodelivery systems adopted for developing functional foods, depicting their classifications, compositions, preparation methods, challenges, release and absorption of β-carotene in the gastrointestinal tract (GIT) and possible risks and future prospects.

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“…Xanthan gum coated liposome has shown high retention ability for encapsulated β-carotene (2 molar β-carotene) during 90 days of storage at under refrigerated conditions [228]. L-α-Dipalmitoylphosphatidylcholine based liposomes was evaluated for release of β-carotene in simulated digestive system and it was observed that only 5-10% of total encapsulated β-carotene was released under gastric digestion conditions while 30-40% of total encapsulated β-carotene was released under intestinal digestive fluid [229]. Liposome have also been reported improved stability for encapsulated β-carotene [166,225,228,[230][231][232][233].…”

Section: Liposomesmentioning

confidence: 99%

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Maurya¹,

Shakya²,

Aggarwal³

et al. 2021

Preprint

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Accruing evidence on the influence of β-carotene regarding the prevention of several chronic diseases - in addition to its well-acknowledged role in vision has been a strong driver for developing alternative delivery systems. Though oral delivery is accepted as the most fitting, mild and safe path for delivering bioactive agents, β-carotene delivery via food items poses challenges due to its lipophilic nature, poor water-solubility, high chemical/photochemical instability and poor oral bioavailability. Nanotechnology has opened new windows for delivering bioactive agents. Their physiochemical characteristics, i.e. small size, high surface area, unique composition, biocompatibility and biodegradability make these nanomaterials an attractive tool for β-carotene delivery. Delivering β-carotene through nanoparticles does not only improve its bioavailability/bioaccumulation in target tissues, but also lessens its sensitivity against environmental factors during processing. Regardless of these benefits, nanocarriers inherit some limitations, such as variations in sensory quality, modification of the food matrix, increasing costs, as well as limited consumer acceptance and regulatory challenges. This research area has been rapidly evolved, with a plethora of innovative nano-engineered materials, including micelles, nano/microemulsion, liposomes, niosomes, solid-lipid nanoparticles and nanostructured lipid carriers. These nano-delivery systems make conventional delivery systems appear archaic and promise better solubilization, protection during processing, improved shelf-life, higher bioavailability as well as controlled and targeted release. This review provides information on the state of knowledge on β-carotene nano-delivery systems adopted for developing functional foods: depicting their classification, composition, preparation methods, challenges, release-and absorption of β-carotene in the GIT and possible risks and future prospects.

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Biophysical characterization of lutein or beta carotene-loaded cationic liposomes

Abstract: The interactions between carotenoids and membrane constituents are vital for understanding the mechanism of their dynamic action.

Cited by 18 publications

References 65 publications

Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge

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