Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

Saeed, Abdu; Qusti, Safaa; Almarwani, Rawan Hamdan; Jambi, Ebtihaj J.; Alshammari, Eida M.; Gusty, Naeem F.; Balgoon, Maha J.

doi:10.1039/d1ra03786b

Cited by 8 publications

(2 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Al accumulation in the brain generates misfolded proteins and facilitates hyperphosphorylation and aggregation (Colomina and Peris-Samperdo, 2017;Niu 2018). AlCl 3 is commonly used to develop aluminum-induced animal models for AD, where it is suggested to cause shrinking of hippocampus pyramidal cells (Saeed et al, 2021), neural cell death, and cognitive deficits similar to AD (Zhang 2018).…”

Section: Discussionmentioning

confidence: 99%

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

2022

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a neurological illness that causes severe cognitive impairment. AD patients also experience at least one of the neuropsychiatric symptoms including apathy, depression, and anxiety during the course of their life. Acetylcholine esterase inhibitors are the available treatment options to alleviate cognitive deficits, whereas methylphenidate (MPH), a psychostimulant, is considered for the treatment of apathy in AD patients. Rosmarinus officinalis, a perennial herb, has been potentially known to have antioxidant and anti-inflammatory properties. The present study investigated the potential effects of MPH and R. officinalis in comparison with the standard drug, Donepezil, on cognition, anxiety, and depression in the AlCl3-induced mouse model of AD. The animals were divided into eight groups (n = 8, each). The results revealed that the MPH- and R. officinalis-treated groups significantly improved memory impairment, whereas R. officinalis substantially reduced depression and anxiety as compared with other treatment groups. MPH treatment induced an antidepressant effect and increased anxiety-like behavior. Moreover, the AlCl3 exposure led to the formation of amyloid beta (Aβ) plaques in mice hippocampus; however, none of the tested drugs caused a significant reduction in amyloid burden at the selected doses. The present study suggested the potential of R. officinalis to improve memory as well as neuropsychiatric symptoms in AD. Although R. officinalis improved cognitive abilities, it did not reduce the amyloid plaque burden, which indicates that the memory-enhancing effects of R. officinalis are due to some alternate mechanism that needs to be explored further.

show abstract

Section: Discussionmentioning

confidence: 99%

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

2022

View full text Add to dashboard Cite

show abstract

“…The hippocampus is a portion of the brain in humans and vertebrates. It plays a vital role in memory formation (Knierim, 2015, Saeed et al, 2021. In this study, to induce memory disorders in rodents, and to select the best model that mimics the AD-like symptoms, the SCO, D-gala, and AlCl 3 models were used.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of scopolamine, D-Galactose and AlCl3-induced Alzheimer’s like disease by enhancing hippocampal neurodegeneration and memory impairment in male rats

2023

ZJPAS

View full text Add to dashboard Cite

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder identified by progressive loss of neurons, cognition decline, and memory deficits. The current study sought out to compare the effects of scopolamine (SCO), D-galactose (D-gala), and aluminum chloride (AlCl 3 ) on memory performance, histological alterations of the hippocampus, and to determine the best model for inducing Alzheimer's-like disease. Twenty-four male adult albino rats (250-300g) were used in this study, which were arbitrarily assigned into four groups: control group (normal saline), SCO group (2 mg/kg), D-gala group (125 mg/kg) and AlCl 3 group (50 mg/kg). The chemicals were given intraperitoneally for 30 days. All the rats were subjected to novel object recognition (NOR) and Barnes maze (BM) tests to assess memory performance. At the end of the period, all the rats were anesthetized, blood samples were taken for hematological and biochemical tests, and the brains were removed for morphometric analysis. The results have demonstrated that SCO, D-gala, and AlCl 3 caused memory impairment in BM and NOR tests, and malondialdehyde serum MDA levels significantly increased. Histological analysis showed degenerative pyknotic cells in the rat hippocampus. The impairment in memory performance and histopathological alterations were higher in the AlCl 3 than in the other models, but the hematological parameters were significantly changed. Therefore, it was concluded that SCO (2 mg/kg) is the best model for mimicking AD-like disease among D-gala and AlCl 3 by enhancing histopathological alternations and declining memory in rats without affecting other study parameters.

show abstract

Post-exposure self-recovery reverses oxidative stress, ameliorates pathology and neurotransmitters imbalance and rescues spatial memory after time-dependent aluminum exposure in rat brain

Asghar,

Siddiqui,

Batool

et al. 2024

Biometals

View full text Add to dashboard Cite

Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells

Abstract: Although the AlCl3 affected the molecular structure of lipids and the morphology of the brain hippocampus cells, the CoQ10 showed a powerful therapeutic antioxidant being helped restore the hippocampal neurons to their normal state.

Cited by 8 publications

References 56 publications

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

Rosmarinus officinalis and Methylphenidate Exposure Improves Cognition and Depression and Regulates Anxiety-Like Behavior in AlCl3-Induced Mouse Model of Alzheimer’s Disease

A comparative study of scopolamine, D-Galactose and AlCl3-induced Alzheimer’s like disease by enhancing hippocampal neurodegeneration and memory impairment in male rats

Post-exposure self-recovery reverses oxidative stress, ameliorates pathology and neurotransmitters imbalance and rescues spatial memory after time-dependent aluminum exposure in rat brain

Contact Info

Product

Resources

About