Biophysical basis of cadherin mediated cell-cell adhesion

Priest, Andrew Vae; Shafraz, Omer; Sivasankar, Sanjeevi

doi:10.1016/j.yexcr.2017.03.015

Cited by 46 publications

(30 citation statements)

References 53 publications

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“…The cadherin family is a group of calcium-dependent type I transmembrane glycoproteins that mediate islet cell adhesion, and are involved in the formation and maintenance of normal cell-cell connections and polarity, differentiation of stem cells, and invasion and metastasis of tumor cells (28). VE-cadherin, which is specific to endothelial cells, belongs to the class of classical cadherins, is mainly distributed in endothelial cells and mediates endothelial cell-cell connections (29).…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II inhibits the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin

et al. 2018

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Angiotensin II (Ang II) is reported to be involved in the development of various cardiovascular diseases by disrupting microvessel permeability, however, the underlying mechanism remains to be elucidated. The present study aimed to investigate the mechanism by which Ang II disrupts microvascular permeability. Rat endothelial cells were subjected to primary culture and identification. Cells in passages 4‑7 were then used for the following experiments. The cells were divided into control, Ang II, and Ang II + valsartan groups, and reverse transcription‑quantitative polymerase chain reaction and western blot analyses were perform to evaluate the expression of zonula occludens‑1 (ZO‑1) and vascular endothelial (VE)‑cadherin in the cells. The distribution of ZO‑1 protein was also detected using immunofluorescence assays. It was found that, compared with the control group, lower expression levels of ZO‑1 and VE‑cadherin were present in the Ang II group (P<0.01). ZO‑1 was also irregularly distributed at the periphery of the cells. In addition, the overexpression of VE‑cadherin reversed the effect of Ang II on the expression and distribution of ZO‑1 in endothelial cells. Together, these results suggested that Ang II inhibited the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin, thus destroying the tight junctions between endothelial cells, which may also be the mechanism by which Ang II is involved in the development of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Angiotensin II inhibits the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin

et al. 2018

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“…These forces are of significant interest due to their implications in tissue development and tissue homeostasis. An in‐depth review of the measurements and models of cell–cell adhesions in tissue constructs are beyond the scope of this review on single‐cell mechanobiology and we encourage readers to refer to many excellent reviews of this field for more details . Nevertheless, these same forces affect the cytoskeleton and the mechanics of the individual cells that make up the tissue.…”

Section: Measurements and Models Of The Contribution Of Adhesions Andmentioning

confidence: 99%

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Rajagopal

Holmes

Lee

2017

WIREs Mechanisms of Disease

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Cellular cytoskeletal mechanics plays a major role in many aspects of human health from organ development to wound healing, tissue homeostasis and cancer metastasis. We summarize the state‐of‐the‐art techniques for mathematically modeling cellular stiffness and mechanics and the cytoskeletal components and factors that regulate them. We highlight key experiments that have assisted model parameterization and compare the advantages of different models that have been used to recapitulate these experiments. An overview of feed‐forward mechanisms from signaling to cytoskeleton remodeling is provided, followed by a discussion of the rapidly growing niche of encapsulating feedback mechanisms from cytoskeletal and cell mechanics to signaling. We discuss broad areas of advancement that could accelerate research and understanding of cellular mechanobiology. A precise understanding of the molecular mechanisms that affect cell and tissue mechanics and function will underpin innovations in medical device technologies of the future. WIREs Syst Biol Med 2018, 10:e1407. doi: 10.1002/wsbm.1407This article is categorized under: Models of Systems Properties and Processes > Mechanistic ModelsPhysiology > Mammalian Physiology in Health and DiseaseModels of Systems Properties and Processes > Cellular Models

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“…These proteins have distinct temporal and spatial localization. The family of Cadherins include E-cadherins (typically expressed in epithelial cells), P-cadherins (typically expressed in placental), N-cadherins (typically expressed in neural cells), B-cadherins and T-cadherins (brain), and M-cadherins (muscle) [142,143]. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane [144,145].…”

Section: Cell Adhesionmentioning

confidence: 99%

Recent Advances in Nanocomposites Based on Aliphatic Polyesters: Design, Synthesis, and Applications in Regenerative Medicine

et al. 2018

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In the last decade, biopolymer matrices reinforced with nanofillers have attracted great research efforts thanks to the synergistic characteristics derived from the combination of these two components. In this framework, this review focuses on the fundamental principles and recent progress in the field of aliphatic polyester-based nanocomposites for regenerative medicine applications. Traditional and emerging polymer nanocomposites are described in terms of polymer matrix properties and synthesis methods, used nanofillers, and nanocomposite processing and properties. Special attention has been paid to the most recent nanocomposite systems developed by combining alternative copolymerization strategies with specific nanoparticles. Thermal, electrical, biodegradation, and surface properties have been illustrated and correlated with the nanoparticle kind, content, and shape. Finally, cell-polymer (nanocomposite) interactions have been described by reviewing analysis methodologies such as primary and stem cell viability, adhesion, morphology, and differentiation processes.

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Biophysical basis of cadherin mediated cell-cell adhesion

Cited by 46 publications

References 53 publications

Angiotensin II inhibits the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin

Angiotensin II inhibits the protein expression of ZO‑1 in vascular endothelial cells by downregulating VE‑cadherin

Computational modeling of single‐cell mechanics and cytoskeletal mechanobiology

Recent Advances in Nanocomposites Based on Aliphatic Polyesters: Design, Synthesis, and Applications in Regenerative Medicine

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