Biophotonic telemedicine for disease diagnosis and monitoring during pandemics: Overcoming COVID-19 and shaping the future of healthcare

Nogueira, Marcelo Saito

doi:10.1016/j.pdpdt.2020.101836

Cited by 15 publications

(6 citation statements)

References 3 publications

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“…Therefore, scattering is associated with the tissue microstructure. On the other hand, absorption is associated with the tissue biomolecular composition, as its absorption bands are dependent on the molecular energy levels (including electronic [ 10 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ], vibrational [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ] and rotational levels [ 57 ]). Tissue absorption is related to biological chromophores (or absorbing biomolecules), which were previously investigated in a number of clinical and preclinical studies [ 58 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization

Nogueira

Maryam

Amissah

et al. 2022

Cancers

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Colorectal cancer (CRC) is the third most common and second most deadly type of cancer worldwide. Early detection not only reduces mortality but also improves patient prognosis by allowing the use of minimally invasive techniques to remove cancer while avoiding major surgery. Expanding the use of microsurgical techniques requires accurate diagnosis and delineation of the tumor margins in order to allow complete excision of cancer. We have used diffuse reflectance spectroscopy (DRS) to identify the main optical CRC biomarkers and to optimize parameters for the integration of such technologies into medical devices. A total number of 2889 diffuse reflectance spectra were collected in ex vivo specimens from 47 patients. Short source-detector distance (SDD) and long-SDD fiber-optic probes were employed to measure tissue layers from 0.5 to 1 mm and from 0.5 to 1.9 mm deep, respectively. The most important biomolecules contributing to differentiating DRS between tissue types were oxy- and deoxy-hemoglobin (Hb and HbO2), followed by water and lipid. Accurate tissue classification and potential DRS device miniaturization using Hb, HbO2, lipid and water data were achieved particularly well within the wavelength ranges 350–590 nm and 600–1230 nm for the short-SDD probe, and 380–400 nm, 420–610 nm, and 650–950 nm for the long-SDD probe.

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Section: Introductionmentioning

confidence: 99%

Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization

Nogueira

Maryam

Amissah

et al. 2022

Cancers

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“…For all the aforementioned reasons, a non-invasive, real-time point-of-care method to detect and accurately diagnose cancer and premalignancies at early stages could benefit patients as well as decrease the risk of oral cancer incidence and mortality. One of the most cost-effective methods to diagnose cancer is the optical biopsy [1,3,[10][11][12][13][14][15][16][17][18]. The term optical biopsy is widely used in optical spectroscopy [6,14,[19][20][21][22][23][24], which assists in the diagnostic process and analyzes optical properties [19,[25][26][27] associated with tissue biochemistry [3][4][5][6][7][8][9]14,16,[23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Profiles of In Vivo Oral Mucosa by Using a Portable Raman Spectroscopy System

Nogueira

Ribeiro

Pires

et al. 2021

Optics

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Most oral injuries are diagnosed by histopathological analysis of invasive and time-consuming biopsies. This analysis and conventional clinical observation cannot identify biochemically altered tissues predisposed to malignancy if no microstructural changes are detectable. With this in mind, detailed biochemical characterization of normal tissues and their differentiation features on healthy individuals is important in order to recognize biomolecular changes associated with early tissue predisposition to malignant transformation. Raman spectroscopy is a label-free method for characterization of tissue structure and specific composition. In this study, we used Raman spectroscopy to characterize the biochemistry of in vivo oral tissues of healthy individuals. We investigated this biochemistry based on the vibrational modes related to Raman spectra of four oral subsites (buccal, gingiva, lip and tongue) of ten volunteers as well as with principal component (PC) loadings for the difference between the four types of oral subsites. Therefore, we determined the biochemical characteristics of each type of healthy oral subsite and those corresponding to differentiation of the four types of subsites. In addition, we developed a spectral reference of oral healthy tissues of individuals in the Brazilian population for future diagnosis of early pathological conditions using real-time, noninvasive and label-free techniques such as Raman spectroscopy.

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“…This makes the early detection of lung complications especially difficult and, as a consequence, the COVID-19 infection becomes deadly for vulnerable individuals. Early detection can be achieved with optical methods, which allow molecular-sensitive and real-time analysis of biological tissues [4,5]. Optical methods are suitable for theranostics applications involving on-site treatment and control of its dosimetry based on the infection status.…”

mentioning

confidence: 99%

“…Early COVID-19 detection and treatment monitoring can be performed by using near-infrared (NIR) spectroscopy to monitor the pulmonary water content, blood oxygenation and heart rate [4,5]. Since blood oxygenation decreases in ARDS patients and the water content increases and in the pneumonia ones, NIR spectroscopy is especially useful in cases with these manifestations.…”

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confidence: 99%

Biophotonic telemedicine for disease diagnosis and monitoring during pandemics: Overcoming COVID-19 and shaping the future of healthcare

Cited by 15 publications

References 3 publications

Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization

Insights into Biochemical Sources and Diffuse Reflectance Spectral Features for Colorectal Cancer Detection and Localization

Biochemical Profiles of In Vivo Oral Mucosa by Using a Portable Raman Spectroscopy System

Optical theranostics and treatment dosimetry for COVID-19 lung complications: Towards increasing the survival rate of vulnerable populations

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