Biopharmaceutical Assessment and Irritation Potential of Microemulsions and Conventional Systems Containing Oil from Syagrus cearensis for Topical Delivery of Amphotericin B Using Alternative Methods

Sousa, Giovana Damasceno; Kishishita, Juliana; Aquino, Kátia Aparecida da Silva; Presgrave, Octávio Augusto França; Leal, Leila Bastos; Santana, Davi Pereira de

doi:10.1208/s12249-016-0663-3

Cited by 18 publications

(8 citation statements)

References 35 publications

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“…The destabilization mechanisms that emulsions may undergo largely depend on the surfactant selected. Emulsions containing Kolliphor EL, a novel emulsifier with a hydrophilic–lipophilic balance of between 12 and 14, are promising formulations, given their high retention, their ability to increase the bioavailability of drugs and their ability to solubilize some vitamins such as vitamins A, D, E and K …”

Section: Introductionmentioning

confidence: 99%

Strategies for reducing Ostwald ripening phenomenon in nanoemulsions based on thyme essential oil

et al. 2019

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BACKGROUND: White thyme essential oil, which can be incorporated in clean-label and food emulsion-based products, is a natural antimicrobial agent. However, emulsions containing essential oils commonly undergo Ostwald ripening as the main destabilization process. The main objective of this work was to evaluate various strategies for the inhibition of Ostwald ripening so as to develop stable nanoemulsions containing white thyme essential oil as food preservative and Kolliphor EL as surfactant.RESULTS: In a first approach, the influence of the surfactant/dispersed phase ratio and the number of cycles through a microfluidizer on droplet size distribution was evaluated. Unfortunately, these emulsions underwent Ostwald ripening, which was demonstrated by the application of the Lifshitz-Slyozov-Wagner theory. In order to reduce this destabilization mechanism, two different techniques based on the modification of the formulation (addition of rosin gum or Aerosil COK84) were analysed using laser diffraction and multiple light scattering techniques. The addition of rosin gum inhibited the Ostwald ripening mechanism, but only partially. Conversely, the incorporation of Aerosil COK84 to the continuous phase led to a gel-like rheological behaviour which seemed to practically avoid Ostwald ripening. CONCLUSIONS: Aerosil particles cover the droplets and form a three-dimensional network suggesting a Pickering stabilization, which was confirmed using transmission electronic microscopy. The results confirmed the role of Aerosil COK84, not only as a thickener or gelling agent, but also as an Ostwald ripening inhibitor.

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Section: Introductionmentioning

confidence: 99%

Strategies for reducing Ostwald ripening phenomenon in nanoemulsions based on thyme essential oil

et al. 2019

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“…This assay has been widely used to assess the irritant potential of topical medicines and cosmetics that may come in contact with the eyes [10]. According to our results (Table 3) all creams were classified as nonirritant, suggesting that they are safe for topical application, including in the face.…”

Section: Irritant Potentialmentioning

confidence: 72%

New Oils for Cosmetic O/W Emulsions: In Vitro/In Vivo Evaluation

et al. 2018

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Abstract:The aim of this study was to design new cosmetic formulations containing oils from catolé, licuri and spent coffee grounds, and to evaluate their immediate and long-term effects on skin barrier function and skin hydration. Nonionic oil-in-water (o/w) emulsions were prepared and physicochemically characterized. The effects of the formulations were assessed by volunteers and by measuring the water content of the epidermis (WCE) and transepidermal water loss (TEWL) both two hours and 20 days after daily application. The irritation potential was evaluated using three different methods: the Hen's egg chorioallantoic membrane test (HET-CAM); the observation of undesirable effects after skin formulation application, and by using the L*a*b* system to verify changes in skin coloring. The results obtained showed that the formulations containing 10% of these oils presented promising characteristics in the improvement of hydration and skin barrier function when compared to the baseline values and with the placebo cream. According to the sensory evaluation performed, all creams were found to have great acceptability.

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“…Also, the microemulsions exhibited no phase separation, turbidity or drug precipitation after 3 months of storage at long term condition. Afterwards, droplet size and PDI of the formulations were measured because determination of droplet size and distribution is one of the most important parameters for evaluating physical stability of microemulsions [33]. Evaluating measurements of droplet size and PDI, all of ETD loaded microemulsion formulations could be considered as a physically stable system for 3 months (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

Saribey¹,

Kahraman²,

Erdal³

et al. 2021

jrp

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The aim of this work was to develop colloidal nanocarriers for skin delivery of etodolac (ETD), which is a non-steroidal anti-inflammatory drug orally used for the management of acute pain and inflammation, but leads to unfavourable effects on the stomach. The oleic acid and blend of Labrasol/Trancutol P were used as oil phase and surfactant/co-surfactant mixture in the microemulsion formulations, respectively. ETD loaded microemulsions selecting the microemulsion region of pseudo-ternary phase diagrams were prepared, and then the microemulsions were characterised to confirm formation of oil in water microemulsions via optical isotropy, refractive index, droplet size, electrical conductivity, rheological behaviour and morphological analysis. In vitro permeation of ETD through porcine skin was evaluated using Franz diffusion cells for stable ETD loaded microemulsions. ATR-FTIR spectroscopy analysis was performed to elucidate interaction between the microemulsion components and stratum corneum structure on the molecular level. Confocal laser scanning microscopy analysis was further carried out to visualize skin penetration enhancement effect of the microemulsion formulation consisting of a model lipophilic fluorescent marker, Nile Red. The results indicated that the developed microemulsion formulation consisting of oleic acid, Labrasol, Transcutol P and water offer a potential approach to enhance skin delivery of ETD for topical treatment of inflammatory diseases.

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Biopharmaceutical Assessment and Irritation Potential of Microemulsions and Conventional Systems Containing Oil from Syagrus cearensis for Topical Delivery of Amphotericin B Using Alternative Methods

Cited by 18 publications

References 35 publications

Strategies for reducing Ostwald ripening phenomenon in nanoemulsions based on thyme essential oil

Strategies for reducing Ostwald ripening phenomenon in nanoemulsions based on thyme essential oil

New Oils for Cosmetic O/W Emulsions: In Vitro/In Vivo Evaluation

Design and characterisation of colloidal nanocarriers for enhanced skin delivery of etodolac

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