Biopartitioning micellar separation methods: modelling drug absorption

Escuder-Gilabert, Laura; Martı́nez-Pla, J.J.; Sagrado, S.; Villanueva-Camañas, R.M.; Medina-Hernández, M.J.

doi:10.1016/s1570-0232(03)00606-8

Cited by 95 publications

(49 citation statements)

References 88 publications

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“…The systems include the immobilized artificial membrane (Barbato et al, 1998), biopartitioning micellar chromatography (Escuder-Gilabert et al, 2003;Waters et al, 2013), liposome electrokinetic chromatography (Wang et al, 2009), and keratin immobilized on the silica as a stationary phase (Turowski and Kaliszan, 1997). However, in respect to the optimization of the formulation destined for the administration onto the skin, the effects of various additives and carriers/vehicles on the drug penetration, these chromatographic systems exhibit a very limited potential and are therefore not further discussed in this review.…”

Section: Artificial In Vitro Skin Modelsmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

178

135

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Abstract(Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the product development. A rational approach in designing and optimizing skin formulations requires well-defined skin models, able to identify and evaluate the intrinsic properties of the formulation. Most of the current optimization relies on the use of suitable ex vivo animal/human models.However, increasing restrictions in use and handling of animals and human skin stimulated the search for suitable artificial skin models. This review attempts to provide an unbiased overview of the most commonly used models, with emphasis on their limitations and advantages. The choice of the most applicable in vitro model for the particular purpose should be based on the interplay between the availability, easiness of the use, cost and the respective limitations.

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Section: Artificial In Vitro Skin Modelsmentioning

confidence: 99%

In vitro skin models as a tool in optimization of drug formulation

Flaten

Palac²,

Engesland

et al. 2015

European Journal of Pharmaceutical Sciences

178

135

View full text Add to dashboard Cite

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“…The IAM retention data of drugs were used to estimate brain to blood partition [88] and compound permeation through the intestinal wall [89]. There are several publications [90][91][92][93] about the use of bio-partitioning micellar chromatographic retention to mimic biological in vivo distribution processes. However, when the physico-chemical or bio-mimetic models are applied for the estimation of compounds in vivo behaviour it is very important to keep in mind the limitations of such models.…”

Section: Modelling Unbound Volume Of Distributionmentioning

confidence: 99%

Application of High Performance Liquid Chromatography for the Measurements of Lipophilicity and Biomimetic Binding Properties in Drug Discovery

Valkó¹

2012

Physico-Chemical Methods in Drug Discovery and Development

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“…In the past few years, several techniques have been developed for combinatorial chemistry that can be used to reintroduce natural products as an important source for new compounds in the first step in drug development (Escuder-Gilabert et al, 2003). Biochromatography with immobilized protein stationary phases has been applied to probing the interaction between groups of compounds in TCM and the proteins (Wang et al, 2000a,b).…”

Section: Introductionmentioning

confidence: 99%

LC‐MS analysis for the components captured by ECV304 cell from extract of Aconitum szechenyianum Gay.

Yuan

Zhang

Kang

et al. 2008

Biomedical Chromatography

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A novel method of cell affinity screening (CAS), cell affinity capture coupled with LC-MS analysis, was developed for screening the bioactive compounds related to cardiovascular diseases from the natural product libraries. One of the major characteristics lies in its function in affinity-capturing and separating the bioactive components from the natural product libraries in vitro. Another characteristic is its use in analyzing and identifying the target compounds, by employing high-performance liquid chromatography and mass spectrometry. CAS was used for screening the bioactive components from the alkaloid extract derived from Aconitum szechenyianum Gay. Of the five components found to be bound to the oxidative-damaged endothelial cells, the two compounds identified, mesaconitine and aconitine, were recognized in the literature as being related to cardiovascular diseases.

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Biopartitioning micellar separation methods: modelling drug absorption

Cited by 95 publications

References 88 publications

In vitro skin models as a tool in optimization of drug formulation

In vitro skin models as a tool in optimization of drug formulation

Application of High Performance Liquid Chromatography for the Measurements of Lipophilicity and Biomimetic Binding Properties in Drug Discovery

LC‐MS analysis for the components captured by ECV304 cell from extract of Aconitum szechenyianum Gay.

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