Bioorthogonal Chemistry and Bioconjugation: Synergistic Tools for Biology and Biomedicine

Biodegradable nanoemulsion-based bioorthogonal nanocatalysts for intracellular generation of anticancer therapeutics

“…[20][21][22][23] Inorganic nanomaterials have been used for encapsulating TMCs, generating stable bioorthogonal 'nanozymes' with high catalytic efficiency. 19,24 These nanozymes provide in situ 'drug nanofactories' for several therapeutic applications, including cancer and infectious diseases. [25][26][27] However, inorganic nanomaterials are typically non-degradable and can persist within the body, causing unwanted side effects.…”

All-natural gelatin-based bioorthogonal catalysts for efficient eradication of bacterial biofilms

“…22,23 Moreover, current nanozyme platforms rely heavily on the use of heavy metal catalysts such as Ru and Pd, resulting in the potential for long-term side effects including hepato-, geno-, and neurotoxicity. 24,25 In this article, we describe the development of an all-natural biopolymeric 'polyzyme' nano-emulsion platform, 26 aiming to provide a highly safe and efficient antimicrobial platform for potential clinical applications (Fig. 1).…”

“…22,23 Moreover, current nanozyme platforms rely heavily on the use of heavy metal catalysts such as Ru and Pd, resulting in the potential for long-term side effects including hepato-, geno-, and neurotoxicity. 24,25…”

Bioconjugate Chemistry: Enabling Innovation and Fostering Community at the Nexus of Synthetic and Biological Research

“…Further, I extend my sincere thanks to the whole editorial team, including the outstanding team of associate editors, managing editors, our authors, reviewers, and many others in the community that have served the journal. The editorial team has published a number of high quality and thoughtful editorials and special issues in the field to highlight many important facets of bioconjugate chemistry. − Lastly, I thank Prof. Bradley Smith, who is stepping down after 10 years of service as Associate Editor, for his dedication and service to the field and journal.…”