Biomonitoring of the cytogenetic effect of antitumor therapy by means of micronucleus assay in exfoliated epithelial cells

Comments on the paper by E. M. Minicucci et al. “DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy”

“…It is interesting that significantly elevated numbers of MN and/or cells with MN were registered in oral cells of nurses exposed to cytostatic drugs (for review see [2] and [10]). …”

“…I read the paper by Minicucci et al ''DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy'' [1] with great interest because recently I analyzed all available literature sources concerning the influence of chemo-and radiotherapies on exfoliated mucosal cells [2]. The problem of possible micronuclei (MN)-inducing activity of antiblastics on epithelial oral mucosa cells has not been studied well.…”

“…The problem of possible micronuclei (MN)-inducing activity of antiblastics on epithelial oral mucosa cells has not been studied well. Only four papers were published concerning cancer patients (for review see [2]) and two concerning patients with other diseases treated with cytostatics [3,4].…”