Comments on the paper by E. M. Minicucci et al. “DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy”

Nersesyan, Armen

doi:10.1007/s10238-008-0018-9

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…In conclusion, we would like to thank Dr. Nersesyan, who carefully evaluates critically all recently published studies using the micronucleus assay in exfoliated cells under different protocols and paradigms, such as carcinogenesis, candidiasis, exposure to chemical compounds, chemotherapy, Behçet disease, and chronic tonsillitis [12][13][14] . Certainly, such discussion will improve the use of this subjective technique when assessing the human risk for biomonitoring studies around the world.…”

mentioning

confidence: 99%

Cytogenetic Biomonitoring in Buccal Mucosa Cells from Young Smokers

Silva¹,

Ribeiro²

2016

Acta Cytologica

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confidence: 99%

Cytogenetic Biomonitoring in Buccal Mucosa Cells from Young Smokers

Silva¹,

Ribeiro²

2016

Acta Cytologica

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“…The significantly shorter lifespan of buccal cells – max. 28 days [12] – could have blurred the potentially positive long time effect of the intervention, as acute changes in the participants’ health status, which are common in elderly aged around their life-expectancy, can have much stronger effects on this tissue, compared to lymphocytes with a half-life in the human body of more than two years [43,44].…”

Section: Discussionmentioning

confidence: 99%

Chromosomal stability in buccal cells was linked to age but not affected by exercise and nutrients - Vienna Active Ageing Study (VAAS), a randomized controlled trial

et al. 2020

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The purpose of this study was to investigate the effect of six months strength training with or without supplementing protein and vitamins, on chromosomal integrity of buccal cells in institutionalized elderly.One hundred seventeen women and men (65–98 years) performed either resistance training (RT), RT combined with a nutritional supplement (RTS) or cognitive training (CT) twice per week for six months. Participants’ fitness was measured using the 6 min walking, the chair rise, and the handgrip strength test. Genotoxicity and cytotoxicity parameters were investigated with the Buccal Micronucleus Cytome (BMcyt) assay.Six minutes walking and chair rise performance improved significantly, however, no changes of the parameters of the BMcyt were detected. Age and micronuclei (MN) frequency correlated significantly, for both women (r = 0.597, p = 0.000) and men (r = 0.508, p = 0.000). Squared regressions revealed a significant increase in the MN frequency of buccal cells with age (R2 = 0.466, p = 0.000).Interestingly and contrary to what was shown in blood lymphocytes, chromosomal damage in buccal cells increases until very old age, which might qualify them as a valid biomarker for aging. Unexpectedly, in this group of institutionalized elderly, resistance training using elastic bands had no effect on chromosomal damage in buccal cells.

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“…The right time for sampling BMC after exposure is not known yet. Recently, this problem has been briefly discussed [2]. It is assumed that MNi appear in basal cells, and then the cells from the basal layer migrate through the prickle cell and the intermediate layer to the surface layer where they can be obtained.…”

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confidence: 99%