Biomonitoring of Polycyclic Aromatic Hydrocarbons — Human Exposure

Seidel, Albrecht

doi:10.1142/9781860949333_0003

Cited by 3 publications

(2 citation statements)

References 59 publications

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“…These organics are commonly found in fossil fuels like coal and tar deposits and are emitted owing to incomplete combustion of organic matters. Some PAH compounds are also present in the effluents from medicine, pesticides, dyes, and plastic manufacturing units (Seidel, 2005). A majority are latent carcinogens, so when mixed, the water becomes unfit for use.…”

Section: Removal Of Polycyclic Aromatic Hydrocarbonmentioning

confidence: 99%

MEUF for removal and recovery of valuable organic components present in effluents: A process intensified technology

Das

Sharma

Singh

et al. 2022

Water Environment Research

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In recent years, the domain of the research space in novel separation process has been led by membrane systems as a panacea providing multifarious benefits of high separation efficiency, elimination of extreme process conditions, sustainability, and environment friendliness coupled with high operational flexibility. In this niche area, often, ultrafiltration is touted as a robust separation technique due to its high separation efficiency, membrane stability, and lower operating costs. The only drawback of relatively large pore size can be overcome by combining surfactant addition, leading to development of integrated processes termed as Micellar Enhanced Ultrafiltration. MEUF processes isolate and selectively separate valuable organics present in effluent streams.The process characteristics fit the bill as a typified example for process intensification Technology interventions for recycling of surfactants can enhance the cost-competitiveness of the process. This has the potential to develop into a broad-spectrum effluent treatment option with a change of surfactants for target contaminants. Here, in this review, we attempt to critically examine the unique features of this technology, development of spin-offs with wide-ranging applications. Specifically applications in removal of hazardous, and persistent components like dissolved organics have been critically studied. The focus was to highlight the crux of the novel technologies highlighting the efficacy and the underlying concept of process intensification. Practitioner Points• Role of MEUF as a sustainable process intensifying separation technique for removal and recovery of organics.• Novel process development using MEUF.• Comparative performance analysis to assess efficacy.• Discussions on future integrative process development.• Sustainability aspect of MEUF with possibility of byproduct recovery.

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Section: Removal Of Polycyclic Aromatic Hydrocarbonmentioning

confidence: 99%

MEUF for removal and recovery of valuable organic components present in effluents: A process intensified technology

Das

Sharma

Singh

et al. 2022

Water Environment Research

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“…Polycyclic aromatic hydrocarbons (PAHs) comprise a major and ubiquitous class of chemical carcinogens to which humans are continuously exposed. The major sources of human exposure for the non‐smoker are food, either as a result of atmospheric deposition from air or generation by cooking procedures such as barbecuing, and to a lesser extent air (Phillips, ); however, exposure may be much higher in individuals exposed to these compounds occupationally, for example those working in the coke industry and in steel plants (Seidel, ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices

Pushparajah

Plant

et al. 2016

Environ. Toxicol.

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Article:Pushparajah, DS, Plant, KE, Plant, NJ orcid.org/0000-0003-4332-8308 et al.(1 more author) (2017) Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices. Environmental Toxicology, 32 (3 ReuseUnless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices

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ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006

2006

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Of all the chemicals classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC), 90% exert their biological effects through binding of their metabolically activated intermediates to DNA forming covalent DNA adducts. As a consequence DNA adducts are generally considered to be causative and directly related to tumour formation. DNA adduct analyses reflect tissue-specific rates of adduct formation and removal, which depend on carcinogen uptake, metabolic activation, DNA repair, adduct instability and tissue turnover and are thus useful markers of carcinogen exposure. The measurement of carcinogen-DNA adduct levels is central to the understanding of chemical carcinogenesis both in animals and humans to determine molecular mechanisms and exposure. Sensitive methods for DNA adduct analysis used to date are based on (32)P-post-labelling, immunoassay, mass spectrometry and laser-induced fluorescence. The aim of this workshop held over 2 days (29-30 September 2006) at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, was to discuss methodological improvements of DNA adduct detection with emphasis on the (32)P-post-labelling procedure as well as new findings achieved by applying the methods to studies on understanding human cancer mechanisms and to elucidate the relationship between adduct formation and human cancer risk.

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Biomonitoring of Polycyclic Aromatic Hydrocarbons — Human Exposure

Cited by 3 publications

References 59 publications

MEUF for removal and recovery of valuable organic components present in effluents: A process intensified technology

MEUF for removal and recovery of valuable organic components present in effluents: A process intensified technology

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices

ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006

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