Biomolecules–Nanoparticles: Interaction in Nanoscale

Vigneshwaran, N.; Jain, Prateek

doi:10.1007/978-3-642-18312-6_6

Cited by 5 publications

(3 citation statements)

References 36 publications

(31 reference statements)

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“…(iii) As well as the interacting bio-compounds (biomolecules, cells, proximal fluids) that favor a physical, chemical, and mechanical relevant process [1,5]. Mirkin showed that siRNA-based gold nanoparticles inhibit its enzymatic degradation and facilitates its uptake by Hela cells [14].…”

Section: Introductionmentioning

confidence: 99%

Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine

et al. 2019

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Nanotechnology is a multidisciplinary science covering matters involving the nanoscale level that is being developed for a great variety of applications. Nanomedicine is one of these attractive and challenging uses focused on the employment of nanomaterials in medical applications such as drug delivery. However, handling these nanometric systems require defining specific parameters to establish the possible advantages and disadvantages in specific applications. This review presents the fundamental factors of nanoparticles and its microenvironment that must be considered to make an appropriate design for medical applications, mainly: (i) Interactions between nanoparticles and their biological environment, (ii) the interaction mechanisms, (iii) and the physicochemical properties of nanoparticles. On the other hand, the repercussions of the control, alter and modify these parameters in the biomedical applications. Additionally, we briefly report the implications of nanoparticles in nanomedicine and precision medicine, and provide perspectives in immunotherapy, which is opening novel applications as immune-oncology.

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Section: Introductionmentioning

confidence: 99%

Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine

et al. 2019

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“…21 (iii) The biocompounds (cells, biomolecules, and proximal fluids) interacting with the NPs favor mechanical, chemical, and physical changes. 22…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials: Potential Broad Spectrum Antimicrobial Agents

Chidre,

Chavan,

Hulikunte Mallikarjunaiah

et al. 2023

Natural Product Communications

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Nanotechnology is a promising science with new aspects to fight and prevent various diseases using nanomaterials. The capability to expose the structure and functions of biosystems at the nanoscale level supports research leading to development in biology, biotechnology, medicine, and healthcare. This is predominantly advantageous in treating microbial infections as an alternative to antibiotics. However, widespread production, use, and misuse of antibiotics have input to the next-generation alarm for the emergence of multiple-drug-resistant pathogenic bacteria. Due to infectious diseases from these drug-resistant pathogenic strains, human mortality rates have consistently increased and are becoming an epidemic in our society. Consequently, there is a strong demand for developing novel strategies and new materials that can cope with these problems. The emergence of nanotechnology has created many new antimicrobial options. The small size of these nanomaterials is suitable for carrying out biological operations. Several metals and metal oxides, such as silver, copper, gold, zinc oxide, and iron oxide nanoparticle types have shown toxicity toward several pathogenic microbes. Metal-based nanoparticles have been broadly examined for a set of biomedical applications. According to the World Health Organization, the reduced size and selectivity of metal-based nanoparticles for bacteria have established them to be effective against pathogens causing concern. Metal-based nanoparticles are known to have nonspecific bacterial toxicity mechanisms, which not only make the development of resistance by bacteria difficult, but also widen the spectrum of antibacterial activity. Metal-based nanoparticle efficiency studies achieved so far have revealed promising results against both Gram-positive and Gram-negative bacteria. Here we discuss the potential nanomaterials to either treat microbial resistance or induce development of resistance. However, fundamental research is required to focus on the molecular mechanism causing the antimicrobial activity of nanomaterials.

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“…Poros celulares e nucleares, proteínas como actina, tubulina (microtúbulos), hemoglobina, anticorpos, diversas proteínas pequenas, a largura das membranas celular e do complexo de Golgi (cada), tRNA, ribossomos, plasmodesmo, anticorpos etc. estão entre tais estruturas 4 .…”

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A era da nanoescala na Saúde

Waissmann

2013

Visa em Debate

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Biomolecules–Nanoparticles: Interaction in Nanoscale

Cited by 5 publications

References 36 publications

Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine

Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine

Nanomaterials: Potential Broad Spectrum Antimicrobial Agents

A era da nanoescala na Saúde

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