Biomolecules-derived biomaterials

Datta, Lakshmi Priya; Manchineella, Shivaprasad; Govindaraju, T.

doi:10.1016/j.biomaterials.2019.119633

Cited by 111 publications

(102 citation statements)

References 338 publications

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“…In recent years, with the rapid development of bioactive nanoassemblies, the modulation of the topological structures and mimicking of the biological functions of naturally occurring biomacromolecules have become focal points of supramolecular chemistry. These biomacromolecules, including polypeptides, nucleic acids, proteins, and polysaccharides, are fundamental structural units in cells and play critical roles in maintaining physiological functions in living systems [8] . By leveraging controllable host–guest interactions, the co‐assembly of biomacromolecules with cavity‐bearing synthetic macrocycles, especially CBs, has proven to be an effective and powerful strategy to prepare simplified but realistic biological systems, decipher molecular binding modes, construct innovative biomaterials, and develop new disease treatments [9]…”

Section: Introductionmentioning

confidence: 99%

Cucurbituril‐Based Biomacromolecular Assemblies

Liu,

Zhang,

et al. 2020

Angew Chem Int Ed

116

154

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The construction of controlled biomacromolecular assemblies has become a thriving area of supramolecular chemistry. In this context, cucurbiturils (CBs), a class of macrocyclic receptors having robust skeletons, hydrophobic cavities, and carbonyl‐laced portals, have been drawn into the limelight because of their advantageous molecular recognition characteristics with a variety of biomacromolecules, including peptides, nucleic acids, and proteins. In this minireview, we focus on the impressive advances in CB‐based biomacromolecular assemblies, such as in biosensors and assays, the regulation of biochemical reactions, and the treatment of serious diseases. CB‐promoted subcellular bioimaging has also been demonstrated in different organelles. The case studies presented herein demonstrate the numerous applications, from fundamental research to translational applications, of diverse CB‐based supra/biomacromolecular architectures.

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Section: Introductionmentioning

confidence: 99%

Cucurbituril‐Based Biomacromolecular Assemblies

Liu,

Zhang,

et al. 2020

Angew Chem Int Ed

116

154

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“…Apart from the bio‐applications, [11] the broad area of molecular architectonics has rekindled the advanced molecular and material architectures design in the areas of electronics, optics, photonics, catalysis, energy harvesting and storage, piezoelectricity, ferroelectricity, catalysis, and sensing among others [18,19] . The mechanistic insights obtained from the biomolecular assemblies serve as the guiding principles in molecular architectonics mediated design of biomimetics and biomaterials, and the synergistic combination of synthetic and biological components generate hybrid biomaterials [20–22] . Peptide assembly process is driven by thermodynamic and kinetic parameters based on the synergistic effects of various inter and/or intramolecular noncovalent interactions as discussed above [23,24] .…”

Section: Introductionmentioning

confidence: 99%

Molecular Architectonics‐guided Design of Biomaterials

Moorthy

Datta

Govindaraju

2021

Chemistry An Asian Journal

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The quest for mastering the controlled engineering of dynamic molecular assemblies is the basis of molecular architectonics. The rational use of noncovalent interactions to programme the molecular assemblies allow the construction of diverse molecular and material architectures with novel functional properties and applications. Understanding and controlling the assembly of molecular systems are daunting tasks owing to the complex factors that govern at the molecular level. Molecular architectures depend on the design of functional molecular modules through the judicious selection of functional core and auxiliary units to guide the precise molecular assembly and co‐assembly patterns. Biomolecules with built‐in information for molecular recognition are the ultimate examples of evolutionary guided molecular recognition systems that define the structure and functions of living organisms. Explicit use of biomolecules as auxiliary units to command the molecular assemblies of functional molecules is an intriguing exercise in the scheme of molecular architectonics. In this minireview, we discuss the implementation of the principles of molecular architectonics for the development of novel biomaterials with functional properties and applications ranging from sensing, drug delivery to neurogeneration and tissue engineering. We present the molecular designs pioneered by our group owing to the requirement and scope of the article while acknowledging the designs pursued by several research groups that befit the concept.

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“…Structurally, they are renewable materials and also sustainable as they are acquired biologically (plants). Biopolymers also reveal significant property as epitomize; biodegradable in nature, biologically compatible and bacterial resistant activity [ 1 , 2 ]. According to monomeric unit and structurally, biopolymers are diversified into three main classes named as polynucleotides (long polymers); RNA and DNA, are comprised of 13 or more monomers (nucleotide), polypeptides (short polymers), consist of amino acids and lastly, the polysaccharides are polymeric carbohydrate structures which are linearly bonded.…”

Section: Introductionmentioning

confidence: 99%

Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

et al. 2020

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Biopolymers are extensively used for developing drug delivery systems as they are easily available, economical, readily modified, nontoxic, biodegradable and biocompatible. Thiolation is a well reported approach for enhancing mucoadhesive and mechanical properties of polymers. In the present review article, for the modification of biopolymers different thiolation methods and evaluation/characterization techniques have been discussed in detail. Reported literature on thiolated biopolymers with enhanced mechanical and mucoadhesive properties has been presented conspicuously in text as well as in tabular form. Patents filed by researchers on thiolated polymers have also been presented. In conclusion, thiolation is an easily reproducible and efficient method for customization of mucoadhesive and mechanical properties of biopolymers for drug delivery applications.

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Biomolecules-derived biomaterials

Cited by 111 publications

References 338 publications

Cucurbituril‐Based Biomacromolecular Assemblies

Cucurbituril‐Based Biomacromolecular Assemblies

Molecular Architectonics‐guided Design of Biomaterials

Thiolation of Biopolymers for Developing Drug Delivery Systems with Enhanced Mechanical and Mucoadhesive Properties: A Review

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